Impact of Obstructive Sleep Apnea on In-Stent Restenosis in Coronary Heart Disease Patients after Elective Drug-Eluting Stenting
Background: Extensive research has established obstructive sleep apnea (OSA) as a contributing factor to numerous cardiovascular and cerebrovascular diseases. However, whether OSA affects in-stent restenosis (ISR) after elective drug-eluting stenting is unclear. Therefore, the obj...
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IMR Press
2025-01-01
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| Series: | Reviews in Cardiovascular Medicine |
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| Online Access: | https://www.imrpress.com/journal/RCM/26/1/10.31083/RCM25814 |
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| author | Wenjie Yang Zhuoshan Huang Ke Yang Dinghui Liu Junpeng Xiao Zhen Wu Ling Jiang Shan Cao Xujing Xie Shujie Yu |
| author_facet | Wenjie Yang Zhuoshan Huang Ke Yang Dinghui Liu Junpeng Xiao Zhen Wu Ling Jiang Shan Cao Xujing Xie Shujie Yu |
| author_sort | Wenjie Yang |
| collection | DOAJ |
| description | Background: Extensive research has established obstructive sleep apnea (OSA) as a contributing factor to numerous cardiovascular and cerebrovascular diseases. However, whether OSA affects in-stent restenosis (ISR) after elective drug-eluting stenting is unclear. Therefore, the objective of this study was to examine the impact of OSA on ISR in patients with coronary heart disease (CHD) who underwent successful elective drug-eluting stent (DES) implantation. Methods: This study retrospectively analyzed CHD patients who successfully underwent elective coronary stent implantation and overnight sleep breathing monitoring and were readmitted for coronary angiography due to symptoms of CHD at 12 to 26 months after percutaneous coronary intervention (PCI). OSA was diagnosed when the apnea-hypopnea index (AHI) was ≥5 events/hour. ISR was defined as >50% restenosis of the vessel diameter in which the DES was implanted. To explore the association between OSA and ISR among patients with CHD, multivariate logistic regression models were developed and utilized. Results: This study enrolled 206 individuals who were diagnosed with CHD, with a mean age of 62.01 ± 10.27 years, and males constituted 76.2% of the patient population. After a median follow-up period of 15 months following DES implantation, there was a significant increase in the incidence of ISR among patients with moderate to severe OSA, increasing from 10.9% to 31.3% (p < 0.001). According to the fully adjusted model, the occurrence of ISR was found to be independently associated with the presence of OSA (OR: 3.247, 95% CI: 1.373–7.677, p = 0.007). Conclusions: In individuals who underwent elective drug-eluting stenting, OSA is an independent risk factor for ISR. |
| format | Article |
| id | doaj-art-ab29a6c21dd94c79a2fca497d09b9d7d |
| institution | Kabale University |
| issn | 1530-6550 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Reviews in Cardiovascular Medicine |
| spelling | doaj-art-ab29a6c21dd94c79a2fca497d09b9d7d2025-01-25T10:41:20ZengIMR PressReviews in Cardiovascular Medicine1530-65502025-01-012612581410.31083/RCM25814S1530-6550(24)01631-4Impact of Obstructive Sleep Apnea on In-Stent Restenosis in Coronary Heart Disease Patients after Elective Drug-Eluting StentingWenjie Yang0Zhuoshan Huang1Ke Yang2Dinghui Liu3Junpeng Xiao4Zhen Wu5Ling Jiang6Shan Cao7Xujing Xie8Shujie Yu9Department of Cardiology, The Third Affiliated Hospital of Sun Yat-sen University, 510630 Guangzhou, Guangdong, ChinaDepartment of Cardiology, The Third Affiliated Hospital of Sun Yat-sen University, 510630 Guangzhou, Guangdong, ChinaDepartment of Cardiology, The Third Affiliated Hospital of Sun Yat-sen University, 510630 Guangzhou, Guangdong, ChinaDepartment of Cardiology, The Third Affiliated Hospital of Sun Yat-sen University, 510630 Guangzhou, Guangdong, ChinaDepartment of Cardiology, The Third Affiliated Hospital of Sun Yat-sen University, 510630 Guangzhou, Guangdong, ChinaDepartment of Cardiology, The Third Affiliated Hospital of Sun Yat-sen University, 510630 Guangzhou, Guangdong, ChinaDepartment of Cardiology, The Third Affiliated Hospital of Sun Yat-sen University, 510630 Guangzhou, Guangdong, ChinaDepartment of Cardiology, The Third Affiliated Hospital of Sun Yat-sen University, 510630 Guangzhou, Guangdong, ChinaDepartment of Cardiology, The Third Affiliated Hospital of Sun Yat-sen University, 510630 Guangzhou, Guangdong, ChinaDepartment of Cardiology, The Third Affiliated Hospital of Sun Yat-sen University, 510630 Guangzhou, Guangdong, ChinaBackground: Extensive research has established obstructive sleep apnea (OSA) as a contributing factor to numerous cardiovascular and cerebrovascular diseases. However, whether OSA affects in-stent restenosis (ISR) after elective drug-eluting stenting is unclear. Therefore, the objective of this study was to examine the impact of OSA on ISR in patients with coronary heart disease (CHD) who underwent successful elective drug-eluting stent (DES) implantation. Methods: This study retrospectively analyzed CHD patients who successfully underwent elective coronary stent implantation and overnight sleep breathing monitoring and were readmitted for coronary angiography due to symptoms of CHD at 12 to 26 months after percutaneous coronary intervention (PCI). OSA was diagnosed when the apnea-hypopnea index (AHI) was ≥5 events/hour. ISR was defined as >50% restenosis of the vessel diameter in which the DES was implanted. To explore the association between OSA and ISR among patients with CHD, multivariate logistic regression models were developed and utilized. Results: This study enrolled 206 individuals who were diagnosed with CHD, with a mean age of 62.01 ± 10.27 years, and males constituted 76.2% of the patient population. After a median follow-up period of 15 months following DES implantation, there was a significant increase in the incidence of ISR among patients with moderate to severe OSA, increasing from 10.9% to 31.3% (p < 0.001). According to the fully adjusted model, the occurrence of ISR was found to be independently associated with the presence of OSA (OR: 3.247, 95% CI: 1.373–7.677, p = 0.007). Conclusions: In individuals who underwent elective drug-eluting stenting, OSA is an independent risk factor for ISR.https://www.imrpress.com/journal/RCM/26/1/10.31083/RCM25814in-stent restenosisobstructive sleep apneadrug-eluting stent |
| spellingShingle | Wenjie Yang Zhuoshan Huang Ke Yang Dinghui Liu Junpeng Xiao Zhen Wu Ling Jiang Shan Cao Xujing Xie Shujie Yu Impact of Obstructive Sleep Apnea on In-Stent Restenosis in Coronary Heart Disease Patients after Elective Drug-Eluting Stenting Reviews in Cardiovascular Medicine in-stent restenosis obstructive sleep apnea drug-eluting stent |
| title | Impact of Obstructive Sleep Apnea on In-Stent Restenosis in Coronary Heart Disease Patients after Elective Drug-Eluting Stenting |
| title_full | Impact of Obstructive Sleep Apnea on In-Stent Restenosis in Coronary Heart Disease Patients after Elective Drug-Eluting Stenting |
| title_fullStr | Impact of Obstructive Sleep Apnea on In-Stent Restenosis in Coronary Heart Disease Patients after Elective Drug-Eluting Stenting |
| title_full_unstemmed | Impact of Obstructive Sleep Apnea on In-Stent Restenosis in Coronary Heart Disease Patients after Elective Drug-Eluting Stenting |
| title_short | Impact of Obstructive Sleep Apnea on In-Stent Restenosis in Coronary Heart Disease Patients after Elective Drug-Eluting Stenting |
| title_sort | impact of obstructive sleep apnea on in stent restenosis in coronary heart disease patients after elective drug eluting stenting |
| topic | in-stent restenosis obstructive sleep apnea drug-eluting stent |
| url | https://www.imrpress.com/journal/RCM/26/1/10.31083/RCM25814 |
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