Biomarker‐induced gold aggregates enable activatable near‐infrared‐II photoacoustic image‐guided radiosensitization
Abstract Current radiotherapy (RT) lacks the ability to accurately discriminate between tumor and healthy tissues, resulting in significant radiation‐induced damage for patients. Therefore, there is an urgent need for precise RT techniques that can optimize tumor control while minimizing adverse eff...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Online Access: | https://doi.org/10.1002/agt2.652 |
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| author | Qinrui Fu Chuang Wei Xiao Yang Mengzhen Wang Jibin Song |
| author_facet | Qinrui Fu Chuang Wei Xiao Yang Mengzhen Wang Jibin Song |
| author_sort | Qinrui Fu |
| collection | DOAJ |
| description | Abstract Current radiotherapy (RT) lacks the ability to accurately discriminate between tumor and healthy tissues, resulting in significant radiation‐induced damage for patients. Therefore, there is an urgent need for precise RT techniques that can optimize tumor control while minimizing adverse effects on surrounding healthy tissues. In this study, we developed a nanodrug (AuNR@Peptide) composed of furin‐responsive RVRR peptide‐conjugated AuNRs, which integrates an activatable probe and a radiosensitizer into a single system for accurate tumor localization, enabling image‐guided precision RT. Upon reaching the tumor site after intravenous administration, proteolytic cleavage of RVRR substrates on AuNR@Peptide by biomarker triggers aggregation of gold nanorods (AuNRs) into larger aggregates, leading to activation of near‐infrared (NIR)‐II photoacoustic (PA) signals to precisely localize the tumor and enhance tumor retention by preventing migration and backflow of AuNRs. This significantly amplifies radiosensitivity efficiency. The peak time point at which the NIR‐II PA signal was observed at the tumor site after injection serves as a reference for initiating RT, demonstrating substantial improvement in tumor RT through investigations related to radiosensitization mechanisms. The integration of imaging and therapy in this study offers a promising image‐guided therapeutic modality for tumors. |
| format | Article |
| id | doaj-art-ab12e577f23546978f4e296678d3f0ca |
| institution | Kabale University |
| issn | 2692-4560 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Aggregate |
| spelling | doaj-art-ab12e577f23546978f4e296678d3f0ca2025-01-21T08:57:07ZengWileyAggregate2692-45602025-01-0161n/an/a10.1002/agt2.652Biomarker‐induced gold aggregates enable activatable near‐infrared‐II photoacoustic image‐guided radiosensitizationQinrui Fu0Chuang Wei1Xiao Yang2Mengzhen Wang3Jibin Song4Institute for Translational Medicine The Affiliated Hospital of Qingdao University College of Medicine Qingdao University Qingdao ChinaInstitute for Translational Medicine The Affiliated Hospital of Qingdao University College of Medicine Qingdao University Qingdao ChinaInstitute for Translational Medicine The Affiliated Hospital of Qingdao University College of Medicine Qingdao University Qingdao ChinaInstitute for Translational Medicine The Affiliated Hospital of Qingdao University College of Medicine Qingdao University Qingdao ChinaState Key Laboratory of Chemical Resource Engineering College of Chemistry Beijing University of Chemical Technology Beijing ChinaAbstract Current radiotherapy (RT) lacks the ability to accurately discriminate between tumor and healthy tissues, resulting in significant radiation‐induced damage for patients. Therefore, there is an urgent need for precise RT techniques that can optimize tumor control while minimizing adverse effects on surrounding healthy tissues. In this study, we developed a nanodrug (AuNR@Peptide) composed of furin‐responsive RVRR peptide‐conjugated AuNRs, which integrates an activatable probe and a radiosensitizer into a single system for accurate tumor localization, enabling image‐guided precision RT. Upon reaching the tumor site after intravenous administration, proteolytic cleavage of RVRR substrates on AuNR@Peptide by biomarker triggers aggregation of gold nanorods (AuNRs) into larger aggregates, leading to activation of near‐infrared (NIR)‐II photoacoustic (PA) signals to precisely localize the tumor and enhance tumor retention by preventing migration and backflow of AuNRs. This significantly amplifies radiosensitivity efficiency. The peak time point at which the NIR‐II PA signal was observed at the tumor site after injection serves as a reference for initiating RT, demonstrating substantial improvement in tumor RT through investigations related to radiosensitization mechanisms. The integration of imaging and therapy in this study offers a promising image‐guided therapeutic modality for tumors.https://doi.org/10.1002/agt2.652biomarkersimage‐guided radiotherapyNIR‐II photoacoustic imagingradiosensitizationresponsive aggregates |
| spellingShingle | Qinrui Fu Chuang Wei Xiao Yang Mengzhen Wang Jibin Song Biomarker‐induced gold aggregates enable activatable near‐infrared‐II photoacoustic image‐guided radiosensitization Aggregate biomarkers image‐guided radiotherapy NIR‐II photoacoustic imaging radiosensitization responsive aggregates |
| title | Biomarker‐induced gold aggregates enable activatable near‐infrared‐II photoacoustic image‐guided radiosensitization |
| title_full | Biomarker‐induced gold aggregates enable activatable near‐infrared‐II photoacoustic image‐guided radiosensitization |
| title_fullStr | Biomarker‐induced gold aggregates enable activatable near‐infrared‐II photoacoustic image‐guided radiosensitization |
| title_full_unstemmed | Biomarker‐induced gold aggregates enable activatable near‐infrared‐II photoacoustic image‐guided radiosensitization |
| title_short | Biomarker‐induced gold aggregates enable activatable near‐infrared‐II photoacoustic image‐guided radiosensitization |
| title_sort | biomarker induced gold aggregates enable activatable near infrared ii photoacoustic image guided radiosensitization |
| topic | biomarkers image‐guided radiotherapy NIR‐II photoacoustic imaging radiosensitization responsive aggregates |
| url | https://doi.org/10.1002/agt2.652 |
| work_keys_str_mv | AT qinruifu biomarkerinducedgoldaggregatesenableactivatablenearinfrarediiphotoacousticimageguidedradiosensitization AT chuangwei biomarkerinducedgoldaggregatesenableactivatablenearinfrarediiphotoacousticimageguidedradiosensitization AT xiaoyang biomarkerinducedgoldaggregatesenableactivatablenearinfrarediiphotoacousticimageguidedradiosensitization AT mengzhenwang biomarkerinducedgoldaggregatesenableactivatablenearinfrarediiphotoacousticimageguidedradiosensitization AT jibinsong biomarkerinducedgoldaggregatesenableactivatablenearinfrarediiphotoacousticimageguidedradiosensitization |