Agitated Depression Associated With Flurazepam Discontinuation
Agitated depression, also known as melancholia agitata, is a variant of depression characterized by severe symptoms of psychomotor agitation, inner unrest, anxiety, restlessness, prominent vegetative symptoms, and a high risk of suicide. This form of depression is reported to worsen with antidepress...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Case Reports in Psychiatry |
| Online Access: | http://dx.doi.org/10.1155/2024/8845349 |
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| author | Mohamed Salih Reem Mohamed Osman Wala Alim Leena Khalid Wafa Sosal Danya Ibrahim Yassir Mahgoub |
| author_facet | Mohamed Salih Reem Mohamed Osman Wala Alim Leena Khalid Wafa Sosal Danya Ibrahim Yassir Mahgoub |
| author_sort | Mohamed Salih |
| collection | DOAJ |
| description | Agitated depression, also known as melancholia agitata, is a variant of depression characterized by severe symptoms of psychomotor agitation, inner unrest, anxiety, restlessness, prominent vegetative symptoms, and a high risk of suicide. This form of depression is reported to worsen with antidepressants and potentially improve with the use of ECT, lithium, antiepileptics, antipsychotics, and benzodiazepines. We describe a case of a 73-year-old female with a prior history of depression and generalized anxiety disorder who was maintained on flurazepam for 44 years and was admitted for severe depression with psychomotor agitation, prominent vegetative symptoms, thought perseveration, indecisiveness, and psychotic features that emerged following the discontinuation of flurazepam. Symptoms did not resolve with the use of alternative benzodiazepines such as nitrazepam and temazepam and further worsened with the use of several antidepressants. She finally had a complete resolution of these symptoms with a combination of alprazolam, zopiclone, and olanzapine. This case provides insight into this unique variant of depression and the role of GABA agonists in its pathology and management. |
| format | Article |
| id | doaj-art-aaff7b92c1934c6d9befa14146cc6771 |
| institution | Kabale University |
| issn | 2090-6838 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Psychiatry |
| spelling | doaj-art-aaff7b92c1934c6d9befa14146cc67712025-02-02T23:14:32ZengWileyCase Reports in Psychiatry2090-68382024-01-01202410.1155/2024/8845349Agitated Depression Associated With Flurazepam DiscontinuationMohamed Salih0Reem Mohamed Osman1Wala Alim2Leena Khalid3Wafa Sosal4Danya Ibrahim5Yassir Mahgoub6St Davne’ts CampusFaculty of MedicineClinical Documentation Improvement SpecialistFaculty of MedicineFaculty of MedicineFaculty of MedicinePsychiatry and Behavioral HealthAgitated depression, also known as melancholia agitata, is a variant of depression characterized by severe symptoms of psychomotor agitation, inner unrest, anxiety, restlessness, prominent vegetative symptoms, and a high risk of suicide. This form of depression is reported to worsen with antidepressants and potentially improve with the use of ECT, lithium, antiepileptics, antipsychotics, and benzodiazepines. We describe a case of a 73-year-old female with a prior history of depression and generalized anxiety disorder who was maintained on flurazepam for 44 years and was admitted for severe depression with psychomotor agitation, prominent vegetative symptoms, thought perseveration, indecisiveness, and psychotic features that emerged following the discontinuation of flurazepam. Symptoms did not resolve with the use of alternative benzodiazepines such as nitrazepam and temazepam and further worsened with the use of several antidepressants. She finally had a complete resolution of these symptoms with a combination of alprazolam, zopiclone, and olanzapine. This case provides insight into this unique variant of depression and the role of GABA agonists in its pathology and management.http://dx.doi.org/10.1155/2024/8845349 |
| spellingShingle | Mohamed Salih Reem Mohamed Osman Wala Alim Leena Khalid Wafa Sosal Danya Ibrahim Yassir Mahgoub Agitated Depression Associated With Flurazepam Discontinuation Case Reports in Psychiatry |
| title | Agitated Depression Associated With Flurazepam Discontinuation |
| title_full | Agitated Depression Associated With Flurazepam Discontinuation |
| title_fullStr | Agitated Depression Associated With Flurazepam Discontinuation |
| title_full_unstemmed | Agitated Depression Associated With Flurazepam Discontinuation |
| title_short | Agitated Depression Associated With Flurazepam Discontinuation |
| title_sort | agitated depression associated with flurazepam discontinuation |
| url | http://dx.doi.org/10.1155/2024/8845349 |
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