Anticancer Ribosomally Synthesized and Post-Translationally Modified Peptides from Plants: Structures, Therapeutic Potential, and Future Directions
Cancer remains a significant medical challenge, necessitating the discovery of novel therapeutic agents. Ribosomally synthesized and post-translationally modified peptides (RiPPs) from plants have emerged as a promising source of anticancer compounds, offering unique structural diversity and potent...
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2024-12-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/47/1/6 |
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| author | Hyeon-Jeong Hwang Youngsang Nam Chanhee Jang Eun La Kim Eun Seo Jang Yeo Jin Lee Seoung Rak Lee |
| author_facet | Hyeon-Jeong Hwang Youngsang Nam Chanhee Jang Eun La Kim Eun Seo Jang Yeo Jin Lee Seoung Rak Lee |
| author_sort | Hyeon-Jeong Hwang |
| collection | DOAJ |
| description | Cancer remains a significant medical challenge, necessitating the discovery of novel therapeutic agents. Ribosomally synthesized and post-translationally modified peptides (RiPPs) from plants have emerged as a promising source of anticancer compounds, offering unique structural diversity and potent biological activity. This review identifies and discusses cytotoxic RiPPs across various plant families, focusing on their absolute chemical structures and reported cytotoxic activities against cancer cell lines. Notably, plant-derived RiPPs such as rubipodanin A and mallotumides A–C demonstrated low nanomolar IC<sub>50</sub> values against multiple cancer cell types, highlighting their therapeutic potential. By integrating traditional ethnobotanical knowledge with modern genomic and bioinformatic approaches, this study underscores the importance of plant RiPPs as a resource for developing innovative cancer treatments. These findings pave the way for further exploration of plant RiPPs, emphasizing their role in addressing the ongoing challenges in oncology and enhancing the repertoire of effective anticancer therapies. |
| format | Article |
| id | doaj-art-aafe7366ac8e4d4cb9c9c0f34c4c82fa |
| institution | Kabale University |
| issn | 1467-3037 1467-3045 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
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| series | Current Issues in Molecular Biology |
| spelling | doaj-art-aafe7366ac8e4d4cb9c9c0f34c4c82fa2025-01-24T13:27:22ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452024-12-01471610.3390/cimb47010006Anticancer Ribosomally Synthesized and Post-Translationally Modified Peptides from Plants: Structures, Therapeutic Potential, and Future DirectionsHyeon-Jeong Hwang0Youngsang Nam1Chanhee Jang2Eun La Kim3Eun Seo Jang4Yeo Jin Lee5Seoung Rak Lee6College of Pharmacy, Research Institute for Drug Development, Pusan National University, Busan 46241, Republic of KoreaCollege of Pharmacy, Research Institute for Drug Development, Pusan National University, Busan 46241, Republic of KoreaCollege of Pharmacy, Research Institute for Drug Development, Pusan National University, Busan 46241, Republic of KoreaCollege of Pharmacy, Research Institute for Drug Development, Pusan National University, Busan 46241, Republic of KoreaCollege of Pharmacy, Research Institute for Drug Development, Pusan National University, Busan 46241, Republic of KoreaCollege of Pharmacy, Research Institute for Drug Development, Pusan National University, Busan 46241, Republic of KoreaCollege of Pharmacy, Research Institute for Drug Development, Pusan National University, Busan 46241, Republic of KoreaCancer remains a significant medical challenge, necessitating the discovery of novel therapeutic agents. Ribosomally synthesized and post-translationally modified peptides (RiPPs) from plants have emerged as a promising source of anticancer compounds, offering unique structural diversity and potent biological activity. This review identifies and discusses cytotoxic RiPPs across various plant families, focusing on their absolute chemical structures and reported cytotoxic activities against cancer cell lines. Notably, plant-derived RiPPs such as rubipodanin A and mallotumides A–C demonstrated low nanomolar IC<sub>50</sub> values against multiple cancer cell types, highlighting their therapeutic potential. By integrating traditional ethnobotanical knowledge with modern genomic and bioinformatic approaches, this study underscores the importance of plant RiPPs as a resource for developing innovative cancer treatments. These findings pave the way for further exploration of plant RiPPs, emphasizing their role in addressing the ongoing challenges in oncology and enhancing the repertoire of effective anticancer therapies.https://www.mdpi.com/1467-3045/47/1/6phytochemicalsribosomally synthesized and post-translationally modified peptideschemical structureanticancer activitybiosynthesis |
| spellingShingle | Hyeon-Jeong Hwang Youngsang Nam Chanhee Jang Eun La Kim Eun Seo Jang Yeo Jin Lee Seoung Rak Lee Anticancer Ribosomally Synthesized and Post-Translationally Modified Peptides from Plants: Structures, Therapeutic Potential, and Future Directions Current Issues in Molecular Biology phytochemicals ribosomally synthesized and post-translationally modified peptides chemical structure anticancer activity biosynthesis |
| title | Anticancer Ribosomally Synthesized and Post-Translationally Modified Peptides from Plants: Structures, Therapeutic Potential, and Future Directions |
| title_full | Anticancer Ribosomally Synthesized and Post-Translationally Modified Peptides from Plants: Structures, Therapeutic Potential, and Future Directions |
| title_fullStr | Anticancer Ribosomally Synthesized and Post-Translationally Modified Peptides from Plants: Structures, Therapeutic Potential, and Future Directions |
| title_full_unstemmed | Anticancer Ribosomally Synthesized and Post-Translationally Modified Peptides from Plants: Structures, Therapeutic Potential, and Future Directions |
| title_short | Anticancer Ribosomally Synthesized and Post-Translationally Modified Peptides from Plants: Structures, Therapeutic Potential, and Future Directions |
| title_sort | anticancer ribosomally synthesized and post translationally modified peptides from plants structures therapeutic potential and future directions |
| topic | phytochemicals ribosomally synthesized and post-translationally modified peptides chemical structure anticancer activity biosynthesis |
| url | https://www.mdpi.com/1467-3045/47/1/6 |
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