Does preeclampsia impact the gut microbiota of preterm offspring during early infancy?
Abstract Preeclampsia (PE) is a pregnancy complication characterized by high blood pressure and organ damage. This study investigates the differences in the gut microbiota between preterm neonates born to mothers with PE and those born to mothers without PE (PR), aiming to understand how maternal he...
Saved in:
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12967-025-06120-2 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832585445991514112 |
|---|---|
| author | Yang Chen Zhou-Ting Yi Hai-Long Yu Xiao-Yan Wu Jun-Ping Wang Chuan Nie Hui Li Sheng-Hui Li Qiu-Long Yan Tian-Wen He Min-Chai Chen Xin-Yue Yang Ji-Ying Wen Li-Juan Lv |
| author_facet | Yang Chen Zhou-Ting Yi Hai-Long Yu Xiao-Yan Wu Jun-Ping Wang Chuan Nie Hui Li Sheng-Hui Li Qiu-Long Yan Tian-Wen He Min-Chai Chen Xin-Yue Yang Ji-Ying Wen Li-Juan Lv |
| author_sort | Yang Chen |
| collection | DOAJ |
| description | Abstract Preeclampsia (PE) is a pregnancy complication characterized by high blood pressure and organ damage. This study investigates the differences in the gut microbiota between preterm neonates born to mothers with PE and those born to mothers without PE (PR), aiming to understand how maternal health conditions like PE influence neonatal gut microbiota. The early gut microbiota plays a crucial role in neonatal health, and disturbances in its development can have long-term consequences. Fecal samples were collected from preterm neonates of PE and PR mothers at 2 and 6 weeks postpartum and analyzed using shotgun metagenomic sequencing. We found that PE significantly affected the gut microbial composition of preterm neonates, particularly at 2 weeks postpartum. The gut microbial diversity in the PE_2 group was notably lower compared to the PR_2 group, with no significant difference observed between the PR_6 and PE_6 groups. At the phylum level, Firmicutes and Proteobacteria were predominant, with significant differences observed, particularly a lower abundance of Actinobacteria in the PE_2 group. At the genus level, Escherichia, Enterococcus, and Klebsiella were more prevalent in the PE_2 group, whereas Bifidobacterium and Cutibacterium dominated the PR_2 group. The gut virome analysis showed no significant differences among the groups. Functional analysis revealed distinct metabolic pathway activities across the groups, suggesting that early disturbances due to PE impact the establishment of healthy gut microbiota. These findings underscore the substantial influence of maternal health on the early development of the neonatal gut microbiota and highlight the potential long-term health consequences. Additionally, the differences in metabolic pathways further emphasize the impact of preeclampsia on gut microbiota functionality. |
| format | Article |
| id | doaj-art-aaece6d554b444c28e76a8e72458fb9e |
| institution | Kabale University |
| issn | 1479-5876 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj-art-aaece6d554b444c28e76a8e72458fb9e2025-01-26T12:50:23ZengBMCJournal of Translational Medicine1479-58762025-01-0123111310.1186/s12967-025-06120-2Does preeclampsia impact the gut microbiota of preterm offspring during early infancy?Yang Chen0Zhou-Ting Yi1Hai-Long Yu2Xiao-Yan Wu3Jun-Ping Wang4Chuan Nie5Hui Li6Sheng-Hui Li7Qiu-Long Yan8Tian-Wen He9Min-Chai Chen10Xin-Yue Yang11Ji-Ying Wen12Li-Juan Lv13Medical Genetic Center, Guangdong Women and Children HospitalMedical Genetic Center, Guangdong Women and Children HospitalPuensum Genetech InstituteMedical Genetic Center, Guangdong Women and Children HospitalDepartment of Neonatology, Guangdong Women and Children HospitalDepartment of Neonatology, Guangdong Women and Children HospitalDepartment of Obstetrics, Guangdong Women and Children HospitalPuensum Genetech InstituteDepartment of Microbiology, College of Basic Medical Science, Dalian Medical UniversityMedical Genetic Center, Guangdong Women and Children HospitalMedical Genetic Center, Guangdong Women and Children HospitalMedical Genetic Center, Guangdong Women and Children HospitalDepartment of Obstetrics, Guangdong Women and Children HospitalMedical Genetic Center, Guangdong Women and Children HospitalAbstract Preeclampsia (PE) is a pregnancy complication characterized by high blood pressure and organ damage. This study investigates the differences in the gut microbiota between preterm neonates born to mothers with PE and those born to mothers without PE (PR), aiming to understand how maternal health conditions like PE influence neonatal gut microbiota. The early gut microbiota plays a crucial role in neonatal health, and disturbances in its development can have long-term consequences. Fecal samples were collected from preterm neonates of PE and PR mothers at 2 and 6 weeks postpartum and analyzed using shotgun metagenomic sequencing. We found that PE significantly affected the gut microbial composition of preterm neonates, particularly at 2 weeks postpartum. The gut microbial diversity in the PE_2 group was notably lower compared to the PR_2 group, with no significant difference observed between the PR_6 and PE_6 groups. At the phylum level, Firmicutes and Proteobacteria were predominant, with significant differences observed, particularly a lower abundance of Actinobacteria in the PE_2 group. At the genus level, Escherichia, Enterococcus, and Klebsiella were more prevalent in the PE_2 group, whereas Bifidobacterium and Cutibacterium dominated the PR_2 group. The gut virome analysis showed no significant differences among the groups. Functional analysis revealed distinct metabolic pathway activities across the groups, suggesting that early disturbances due to PE impact the establishment of healthy gut microbiota. These findings underscore the substantial influence of maternal health on the early development of the neonatal gut microbiota and highlight the potential long-term health consequences. Additionally, the differences in metabolic pathways further emphasize the impact of preeclampsia on gut microbiota functionality.https://doi.org/10.1186/s12967-025-06120-2PreeclampsiaPreterm neonatesGut microbiomeGut viromeMicrobial diversityShotgun metagenomic sequencing |
| spellingShingle | Yang Chen Zhou-Ting Yi Hai-Long Yu Xiao-Yan Wu Jun-Ping Wang Chuan Nie Hui Li Sheng-Hui Li Qiu-Long Yan Tian-Wen He Min-Chai Chen Xin-Yue Yang Ji-Ying Wen Li-Juan Lv Does preeclampsia impact the gut microbiota of preterm offspring during early infancy? Journal of Translational Medicine Preeclampsia Preterm neonates Gut microbiome Gut virome Microbial diversity Shotgun metagenomic sequencing |
| title | Does preeclampsia impact the gut microbiota of preterm offspring during early infancy? |
| title_full | Does preeclampsia impact the gut microbiota of preterm offspring during early infancy? |
| title_fullStr | Does preeclampsia impact the gut microbiota of preterm offspring during early infancy? |
| title_full_unstemmed | Does preeclampsia impact the gut microbiota of preterm offspring during early infancy? |
| title_short | Does preeclampsia impact the gut microbiota of preterm offspring during early infancy? |
| title_sort | does preeclampsia impact the gut microbiota of preterm offspring during early infancy |
| topic | Preeclampsia Preterm neonates Gut microbiome Gut virome Microbial diversity Shotgun metagenomic sequencing |
| url | https://doi.org/10.1186/s12967-025-06120-2 |
| work_keys_str_mv | AT yangchen doespreeclampsiaimpactthegutmicrobiotaofpretermoffspringduringearlyinfancy AT zhoutingyi doespreeclampsiaimpactthegutmicrobiotaofpretermoffspringduringearlyinfancy AT hailongyu doespreeclampsiaimpactthegutmicrobiotaofpretermoffspringduringearlyinfancy AT xiaoyanwu doespreeclampsiaimpactthegutmicrobiotaofpretermoffspringduringearlyinfancy AT junpingwang doespreeclampsiaimpactthegutmicrobiotaofpretermoffspringduringearlyinfancy AT chuannie doespreeclampsiaimpactthegutmicrobiotaofpretermoffspringduringearlyinfancy AT huili doespreeclampsiaimpactthegutmicrobiotaofpretermoffspringduringearlyinfancy AT shenghuili doespreeclampsiaimpactthegutmicrobiotaofpretermoffspringduringearlyinfancy AT qiulongyan doespreeclampsiaimpactthegutmicrobiotaofpretermoffspringduringearlyinfancy AT tianwenhe doespreeclampsiaimpactthegutmicrobiotaofpretermoffspringduringearlyinfancy AT minchaichen doespreeclampsiaimpactthegutmicrobiotaofpretermoffspringduringearlyinfancy AT xinyueyang doespreeclampsiaimpactthegutmicrobiotaofpretermoffspringduringearlyinfancy AT jiyingwen doespreeclampsiaimpactthegutmicrobiotaofpretermoffspringduringearlyinfancy AT lijuanlv doespreeclampsiaimpactthegutmicrobiotaofpretermoffspringduringearlyinfancy |