Apathy Is Correlated with Widespread Diffusion Tensor Imaging (DTI) Impairment in Amyotrophic Lateral Sclerosis
Apathy is recognized as the most common behavioral change in several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), a multisystem neurodegenerative disorder. Particularly, apathy has been reported to be associated with poor ALS prognosis. However, the brain microstructura...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2018/2635202 |
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| author | Cinzia Femiano Francesca Trojsi Giuseppina Caiazzo Mattia Siciliano Carla Passaniti Antonio Russo Alvino Bisecco Mario Cirillo Maria Rosaria Monsurrò Fabrizio Esposito Gioacchino Tedeschi Gabriella Santangelo |
| author_facet | Cinzia Femiano Francesca Trojsi Giuseppina Caiazzo Mattia Siciliano Carla Passaniti Antonio Russo Alvino Bisecco Mario Cirillo Maria Rosaria Monsurrò Fabrizio Esposito Gioacchino Tedeschi Gabriella Santangelo |
| author_sort | Cinzia Femiano |
| collection | DOAJ |
| description | Apathy is recognized as the most common behavioral change in several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), a multisystem neurodegenerative disorder. Particularly, apathy has been reported to be associated with poor ALS prognosis. However, the brain microstructural correlates of this behavioral symptom, reported as the most common in ALS, have not been completely elucidated. Using diffusion tensor imaging (DTI) and tract-based spatial statistics (TBSS), here we aimed to quantify the correlation between brain microstructural damage and apathy scores in the early stages of ALS. Twenty-one consecutive ALS patients, in King’s clinical stage 1 or 2, and 19 age- and sex-matched healthy controls (HCs) underwent magnetic resonance imaging and neuropsychological examination. Between-group comparisons did not show any significant difference on cognitive and behavioral variables. When compared to HCs, ALS patients exhibited a decreased fractional anisotropy (FA) [p<.05, threshold-free cluster enhancement (TFCE) corrected] in the corpus callosum and in bilateral anterior cingulate cortices. Self-rated Apathy Evaluation Scale (AES) scores and self-rated apathy T-scores of the Frontal Systems Behavior (FrSBe) scale were found inversely correlated to FA measures (p<.05, TFCE corrected) in widespread white matter (WM) areas, including several associative fiber tracts in the frontal, temporal, and parietal lobes. These results point towards an early microstructural degeneration of brain areas biologically involved in cognition and behavior regulation in ALS. Moreover, the significant correlations between apathy and DTI measures in several brain areas may suggest that subtle WM changes may be associated with mild behavioral symptoms in ALS even in the absence of overt cognitive and behavioral impairment. |
| format | Article |
| id | doaj-art-aae592e5333f4f7e934272676082e651 |
| institution | Kabale University |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-aae592e5333f4f7e934272676082e6512025-02-03T01:28:15ZengWileyBehavioural Neurology0953-41801875-85842018-01-01201810.1155/2018/26352022635202Apathy Is Correlated with Widespread Diffusion Tensor Imaging (DTI) Impairment in Amyotrophic Lateral SclerosisCinzia Femiano0Francesca Trojsi1Giuseppina Caiazzo2Mattia Siciliano3Carla Passaniti4Antonio Russo5Alvino Bisecco6Mario Cirillo7Maria Rosaria Monsurrò8Fabrizio Esposito9Gioacchino Tedeschi10Gabriella Santangelo11Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences; MRI Research Center SUN-FISM, Università degli Studi della Campania “Luigi Vanvitelli”, Naples, ItalyDepartment of Medical, Surgical, Neurological, Metabolic and Aging Sciences; MRI Research Center SUN-FISM, Università degli Studi della Campania “Luigi Vanvitelli”, Naples, ItalyDepartment of Medical, Surgical, Neurological, Metabolic and Aging Sciences; MRI Research Center SUN-FISM, Università degli Studi della Campania “Luigi Vanvitelli”, Naples, ItalyDepartment of Medical, Surgical, Neurological, Metabolic and Aging Sciences; MRI Research Center SUN-FISM, Università degli Studi della Campania “Luigi Vanvitelli”, Naples, ItalyDepartment of Psychology, Università degli Studi della Campania “Luigi Vanvitelli”, Naples, ItalyDepartment of Medical, Surgical, Neurological, Metabolic and Aging Sciences; MRI Research Center SUN-FISM, Università degli Studi della Campania “Luigi Vanvitelli”, Naples, ItalyDepartment of Medical, Surgical, Neurological, Metabolic and Aging Sciences; MRI Research Center SUN-FISM, Università degli Studi della Campania “Luigi Vanvitelli”, Naples, ItalyDepartment of Medical, Surgical, Neurological, Metabolic and Aging Sciences; MRI Research Center SUN-FISM, Università degli Studi della Campania “Luigi Vanvitelli”, Naples, ItalyDepartment of Medical, Surgical, Neurological, Metabolic and Aging Sciences; MRI Research Center SUN-FISM, Università degli Studi della Campania “Luigi Vanvitelli”, Naples, ItalyDepartment of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno, Baronissi, Salerno, ItalyDepartment of Medical, Surgical, Neurological, Metabolic and Aging Sciences; MRI Research Center SUN-FISM, Università degli Studi della Campania “Luigi Vanvitelli”, Naples, ItalyDepartment of Psychology, Università degli Studi della Campania “Luigi Vanvitelli”, Naples, ItalyApathy is recognized as the most common behavioral change in several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), a multisystem neurodegenerative disorder. Particularly, apathy has been reported to be associated with poor ALS prognosis. However, the brain microstructural correlates of this behavioral symptom, reported as the most common in ALS, have not been completely elucidated. Using diffusion tensor imaging (DTI) and tract-based spatial statistics (TBSS), here we aimed to quantify the correlation between brain microstructural damage and apathy scores in the early stages of ALS. Twenty-one consecutive ALS patients, in King’s clinical stage 1 or 2, and 19 age- and sex-matched healthy controls (HCs) underwent magnetic resonance imaging and neuropsychological examination. Between-group comparisons did not show any significant difference on cognitive and behavioral variables. When compared to HCs, ALS patients exhibited a decreased fractional anisotropy (FA) [p<.05, threshold-free cluster enhancement (TFCE) corrected] in the corpus callosum and in bilateral anterior cingulate cortices. Self-rated Apathy Evaluation Scale (AES) scores and self-rated apathy T-scores of the Frontal Systems Behavior (FrSBe) scale were found inversely correlated to FA measures (p<.05, TFCE corrected) in widespread white matter (WM) areas, including several associative fiber tracts in the frontal, temporal, and parietal lobes. These results point towards an early microstructural degeneration of brain areas biologically involved in cognition and behavior regulation in ALS. Moreover, the significant correlations between apathy and DTI measures in several brain areas may suggest that subtle WM changes may be associated with mild behavioral symptoms in ALS even in the absence of overt cognitive and behavioral impairment.http://dx.doi.org/10.1155/2018/2635202 |
| spellingShingle | Cinzia Femiano Francesca Trojsi Giuseppina Caiazzo Mattia Siciliano Carla Passaniti Antonio Russo Alvino Bisecco Mario Cirillo Maria Rosaria Monsurrò Fabrizio Esposito Gioacchino Tedeschi Gabriella Santangelo Apathy Is Correlated with Widespread Diffusion Tensor Imaging (DTI) Impairment in Amyotrophic Lateral Sclerosis Behavioural Neurology |
| title | Apathy Is Correlated with Widespread Diffusion Tensor Imaging (DTI) Impairment in Amyotrophic Lateral Sclerosis |
| title_full | Apathy Is Correlated with Widespread Diffusion Tensor Imaging (DTI) Impairment in Amyotrophic Lateral Sclerosis |
| title_fullStr | Apathy Is Correlated with Widespread Diffusion Tensor Imaging (DTI) Impairment in Amyotrophic Lateral Sclerosis |
| title_full_unstemmed | Apathy Is Correlated with Widespread Diffusion Tensor Imaging (DTI) Impairment in Amyotrophic Lateral Sclerosis |
| title_short | Apathy Is Correlated with Widespread Diffusion Tensor Imaging (DTI) Impairment in Amyotrophic Lateral Sclerosis |
| title_sort | apathy is correlated with widespread diffusion tensor imaging dti impairment in amyotrophic lateral sclerosis |
| url | http://dx.doi.org/10.1155/2018/2635202 |
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