Noninvasive detection of twin zygosity using genome‐wide linkage disequilibrium information

Noninvasive detection of twin zygosity using genome‐wide linkage disequilibrium information

Dear Editor, in this study, we propose a novel linkage disequilibrium information‐based noninvasive zygosity (LDNZ) assessment method in twin pregnancies. It combines fetus‐specific allele frequency analysis with LD block to reduce the number of required single nucleotide polymorphism markers and ex...

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Main Authors: Lingrong Kong, Yingjun Yang, Chao Yuan, Xing Wei, Xinyao Zhou, Jia Zhou, Ya Xing, Gang Zou, Qianqian Sun, Luyao Cai, Qiufeng Liang, Yao Zhang, Hongkun Wang, Zesi Liu, Di Wu, Luming Sun
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Clinical and Translational Medicine
Online Access:https://doi.org/10.1002/ctm2.70130
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Summary:Dear Editor, in this study, we propose a novel linkage disequilibrium information‐based noninvasive zygosity (LDNZ) assessment method in twin pregnancies. It combines fetus‐specific allele frequency analysis with LD block to reduce the number of required single nucleotide polymorphism markers and experiment costs. LDNZ method offers a noninvasive, accurate, and cost‐effective solution for zygosity assessment, addressing the need for precise obstetric care in twin pregnancies.
ISSN:2001-1326

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