Maresin1 Alleviates Metabolic Dysfunction in Septic Mice: A 1H NMR-Based Metabolomics Analysis
Maresin1 (MaR1), a new anti-inflammatory and proresolving lipid mediator, has been proven to exert organ-protective effects in septic animal models. However, the potential mechanisms are still not fully elucidated. In this study, we sought to explore the impact of MaR1 on metabolic dysfunction in ce...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2019/2309175 |
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| author | Yu Hao Hong Zheng Ruo-Han Wang Hui Li Li-Li Yang Suwas Bhandari Yong-Jian Liu Jun Han Fang Gao Smith Hong-Chang Gao Sheng-Wei Jin |
| author_facet | Yu Hao Hong Zheng Ruo-Han Wang Hui Li Li-Li Yang Suwas Bhandari Yong-Jian Liu Jun Han Fang Gao Smith Hong-Chang Gao Sheng-Wei Jin |
| author_sort | Yu Hao |
| collection | DOAJ |
| description | Maresin1 (MaR1), a new anti-inflammatory and proresolving lipid mediator, has been proven to exert organ-protective effects in septic animal models. However, the potential mechanisms are still not fully elucidated. In this study, we sought to explore the impact of MaR1 on metabolic dysfunction in cecal ligation and puncture- (CLP-) induced septic mice. We found that MaR1 significantly increased the overall survival rate and attenuated lung and liver injuries in septic mice. In addition, MaR1 markedly reduced the levels of proinflammatory cytokines (TNF-α and IL-6) and alleviated mitochondrial damage. Based on a 1H NMR-based metabolomics analysis, CLP-induced septic mice had increased levels of acetate, pyruvate, and lactate in serum and decreased levels of alanine, aspartate, glutamate, and fumarate in lungs. However, these metabolic disorders, mainly involving energy and amino acid metabolism, can be recovered by MaR1 treatment. Therefore, our results suggest that the protective effects of MaR1 on sepsis could be related to the recovery of metabolic dysfunction and the alleviation of inflammation and mitochondrial damage. |
| format | Article |
| id | doaj-art-aad73cf43c924b78be0879741cdb57bb |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-aad73cf43c924b78be0879741cdb57bb2025-02-03T06:07:31ZengWileyMediators of Inflammation0962-93511466-18612019-01-01201910.1155/2019/23091752309175Maresin1 Alleviates Metabolic Dysfunction in Septic Mice: A 1H NMR-Based Metabolomics AnalysisYu Hao0Hong Zheng1Ruo-Han Wang2Hui Li3Li-Li Yang4Suwas Bhandari5Yong-Jian Liu6Jun Han7Fang Gao Smith8Hong-Chang Gao9Sheng-Wei Jin10Department of Anaesthesia and Critical Care, Second Affiliated Hospital of Wenzhou Medical University, Zhejiang 325027, ChinaInstitute of Metabonomics & Medical NMR, School of Pharmaceutical Sciences, Wenzhou Medical University, Zhejiang 325035, ChinaInstitute of Metabonomics & Medical NMR, School of Pharmaceutical Sciences, Wenzhou Medical University, Zhejiang 325035, ChinaDepartment of Anaesthesia and Critical Care, Second Affiliated Hospital of Wenzhou Medical University, Zhejiang 325027, ChinaDepartment of Anaesthesia and Critical Care, Second Affiliated Hospital of Wenzhou Medical University, Zhejiang 325027, ChinaDepartment of Anaesthesia and Critical Care, Second Affiliated Hospital of Wenzhou Medical University, Zhejiang 325027, ChinaDepartment of Anaesthesia and Critical Care, Second Affiliated Hospital of Wenzhou Medical University, Zhejiang 325027, ChinaDepartment of Anaesthesia and Critical Care, Second Affiliated Hospital of Wenzhou Medical University, Zhejiang 325027, ChinaDepartment of Anaesthesia and Critical Care, Second Affiliated Hospital of Wenzhou Medical University, Zhejiang 325027, ChinaInstitute of Metabonomics & Medical NMR, School of Pharmaceutical Sciences, Wenzhou Medical University, Zhejiang 325035, ChinaDepartment of Anaesthesia and Critical Care, Second Affiliated Hospital of Wenzhou Medical University, Zhejiang 325027, ChinaMaresin1 (MaR1), a new anti-inflammatory and proresolving lipid mediator, has been proven to exert organ-protective effects in septic animal models. However, the potential mechanisms are still not fully elucidated. In this study, we sought to explore the impact of MaR1 on metabolic dysfunction in cecal ligation and puncture- (CLP-) induced septic mice. We found that MaR1 significantly increased the overall survival rate and attenuated lung and liver injuries in septic mice. In addition, MaR1 markedly reduced the levels of proinflammatory cytokines (TNF-α and IL-6) and alleviated mitochondrial damage. Based on a 1H NMR-based metabolomics analysis, CLP-induced septic mice had increased levels of acetate, pyruvate, and lactate in serum and decreased levels of alanine, aspartate, glutamate, and fumarate in lungs. However, these metabolic disorders, mainly involving energy and amino acid metabolism, can be recovered by MaR1 treatment. Therefore, our results suggest that the protective effects of MaR1 on sepsis could be related to the recovery of metabolic dysfunction and the alleviation of inflammation and mitochondrial damage.http://dx.doi.org/10.1155/2019/2309175 |
| spellingShingle | Yu Hao Hong Zheng Ruo-Han Wang Hui Li Li-Li Yang Suwas Bhandari Yong-Jian Liu Jun Han Fang Gao Smith Hong-Chang Gao Sheng-Wei Jin Maresin1 Alleviates Metabolic Dysfunction in Septic Mice: A 1H NMR-Based Metabolomics Analysis Mediators of Inflammation |
| title | Maresin1 Alleviates Metabolic Dysfunction in Septic Mice: A 1H NMR-Based Metabolomics Analysis |
| title_full | Maresin1 Alleviates Metabolic Dysfunction in Septic Mice: A 1H NMR-Based Metabolomics Analysis |
| title_fullStr | Maresin1 Alleviates Metabolic Dysfunction in Septic Mice: A 1H NMR-Based Metabolomics Analysis |
| title_full_unstemmed | Maresin1 Alleviates Metabolic Dysfunction in Septic Mice: A 1H NMR-Based Metabolomics Analysis |
| title_short | Maresin1 Alleviates Metabolic Dysfunction in Septic Mice: A 1H NMR-Based Metabolomics Analysis |
| title_sort | maresin1 alleviates metabolic dysfunction in septic mice a 1h nmr based metabolomics analysis |
| url | http://dx.doi.org/10.1155/2019/2309175 |
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