Magnetic Seizure Therapy for Unipolar and Bipolar Depression: A Systematic Review
Objective. Magnetic seizure therapy (MST) is a novel, experimental therapeutic intervention, which combines therapeutic aspects of electroconvulsive therapy (ECT) and transcranial magnetic stimulation, in order to achieve the efficacy of the former with the safe...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2015/521398 |
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| Summary: | Objective. Magnetic seizure therapy (MST) is a novel, experimental therapeutic intervention,
which combines therapeutic aspects of electroconvulsive therapy (ECT) and transcranial magnetic stimulation, in order to achieve the efficacy
of the former with the safety of the latter. MST might prove to be a valuable tool in the treatment of mood disorders, such as major depressive
disorder (MDD) and bipolar disorder. Our aim is to review current literature on MST. Methods. OVID and MEDLINE databases were used to
systematically search for clinical studies on MST. The terms “magnetic seizure therapy,” “depression,” and “bipolar”
were employed. Results. Out of 74 studies, 8 met eligibility criteria. There was considerable variability in the methods
employed and samples sizes were small,
limiting the generalization of the results. All studies focused on depressive episodes, but few included patients with bipolar disorder.
The studies found reported significant antidepressant effects, with remission rates ranging from 30% to 40%. No significant cognitive
side effects related to MST were found, with a better cognitive profile when compared to ECT. Conclusion. MST was effective in reducing
depressive symptoms in mood disorders, with generally less side effects than ECT. No study focused on comparing MST to ECT on bipolar depression
specifically. |
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| ISSN: | 2090-5904 1687-5443 |