Handling of missing component information for common composite score outcomes used in axial spondyloarthritis research when complete-case analysis is unbiased

Handling of missing component information for common composite score outcomes used in axial spondyloarthritis research when complete-case analysis is unbiased

Abstract Background Observational data on composite scores often comes with missing component information. When a complete-case (CC) analysis of composite scores is unbiased, preferable approaches of dealing with missing component information should also be unbiased and provide a more precise estima...

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Main Authors: Christos Polysopoulos, Stylianos Georgiadis, Lykke Midtbøll Ørnbjerg, Almut Scherer, Daniela Di Giuseppe, Merete Lund Hetland, Michael John Nissen, Gareth T. Jones, Bente Glintborg, Anne Gitte Loft, Johan Karlsson Wallman, Karel Pavelka, Jakub Závada, Ayten Yazici, Maria José Santos, Adrian Ciurea, Burkhard Möller, Brigitte Michelsen, Pawel Mielnik, Johanna Huhtakangas, Heikki Relas, Katja Perdan Pirkmajer, Ziga Rotar, Ross MacDonald, Bjorn Gudbjornsson, Irene van der Horst-Bruinsma, Marleen van de Sande, Myriam Riek
Format: Article
Language:English
Published: BMC 2025-02-01
Series:BMC Medical Research Methodology
Subjects:
Composite score
Missing components
Complete-case analysis
Multiple imputation
Axial spondyloarthritis
Online Access:https://doi.org/10.1186/s12874-025-02515-3
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