TAB2 Promotes the Stemness and Biological Functions of Cervical Squamous Cell Carcinoma Cells
Cancer stem cells are a key population participating in the promotion of the cervical cancer progression through interacting with cancer cells. Existing studies have preliminary revealed that cervical cancer stem cells contribute to tumor recurrence and chemotherapy resistance. However, the specific...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2021/6550388 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832565946003226624 |
|---|---|
| author | Yijia Zhou Yuandong Liao Chunyu Zhang Junxiu Liu Wei Wang Jiaming Huang Qiqiao Du Tianyu Liu Qiaojian Zou Hua Huang Pan Liu Shiyin Ooi Run Chen Meng Xia Hongye Jiang Manman Xu Yuwen Pan Shuzhong Yao |
| author_facet | Yijia Zhou Yuandong Liao Chunyu Zhang Junxiu Liu Wei Wang Jiaming Huang Qiqiao Du Tianyu Liu Qiaojian Zou Hua Huang Pan Liu Shiyin Ooi Run Chen Meng Xia Hongye Jiang Manman Xu Yuwen Pan Shuzhong Yao |
| author_sort | Yijia Zhou |
| collection | DOAJ |
| description | Cancer stem cells are a key population participating in the promotion of the cervical cancer progression through interacting with cancer cells. Existing studies have preliminary revealed that cervical cancer stem cells contribute to tumor recurrence and chemotherapy resistance. However, the specific mechanisms involved in regulating cell functions remain largely unknown. Here, we analyzed published data from public databases and our global transcriptome data, thus identifying cancer-related signaling pathways and molecules. According to our findings, upregulated TAB2 was correlated to stem cell-like properties of cervical cancer. Immunohistochemistry staining of TAB2 in normal and cervical cancer tissues was performed. The cell function experiments demonstrated that knockdown of TAB2 reduced the stemness of cervical cancer cells and, importantly, prevented cervical cancer progression. Collectively, the therapeutic scheme targeting TAB2 may provide an option for overcoming tumor relapse and chemoresistance of cervical cancer via obstructing stemness maintenance. |
| format | Article |
| id | doaj-art-aab4117b127440cea2e398b2f4b616a2 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-aab4117b127440cea2e398b2f4b616a22025-02-03T01:05:32ZengWileyStem Cells International1687-966X1687-96782021-01-01202110.1155/2021/65503886550388TAB2 Promotes the Stemness and Biological Functions of Cervical Squamous Cell Carcinoma CellsYijia Zhou0Yuandong Liao1Chunyu Zhang2Junxiu Liu3Wei Wang4Jiaming Huang5Qiqiao Du6Tianyu Liu7Qiaojian Zou8Hua Huang9Pan Liu10Shiyin Ooi11Run Chen12Meng Xia13Hongye Jiang14Manman Xu15Yuwen Pan16Shuzhong Yao17Department of Obstetrics and Gynecology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080 Guangdong, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080 Guangdong, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080 Guangdong, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080 Guangdong, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080 Guangdong, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080 Guangdong, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080 Guangdong, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080 Guangdong, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080 Guangdong, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080 Guangdong, ChinaDepartment of Obstetrics and Gynecology, Northwest Women’s and Children’s Hospital, Xi’an, Shaanxi, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080 Guangdong, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080 Guangdong, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080 Guangdong, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080 Guangdong, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080 Guangdong, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080 Guangdong, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080 Guangdong, ChinaCancer stem cells are a key population participating in the promotion of the cervical cancer progression through interacting with cancer cells. Existing studies have preliminary revealed that cervical cancer stem cells contribute to tumor recurrence and chemotherapy resistance. However, the specific mechanisms involved in regulating cell functions remain largely unknown. Here, we analyzed published data from public databases and our global transcriptome data, thus identifying cancer-related signaling pathways and molecules. According to our findings, upregulated TAB2 was correlated to stem cell-like properties of cervical cancer. Immunohistochemistry staining of TAB2 in normal and cervical cancer tissues was performed. The cell function experiments demonstrated that knockdown of TAB2 reduced the stemness of cervical cancer cells and, importantly, prevented cervical cancer progression. Collectively, the therapeutic scheme targeting TAB2 may provide an option for overcoming tumor relapse and chemoresistance of cervical cancer via obstructing stemness maintenance.http://dx.doi.org/10.1155/2021/6550388 |
| spellingShingle | Yijia Zhou Yuandong Liao Chunyu Zhang Junxiu Liu Wei Wang Jiaming Huang Qiqiao Du Tianyu Liu Qiaojian Zou Hua Huang Pan Liu Shiyin Ooi Run Chen Meng Xia Hongye Jiang Manman Xu Yuwen Pan Shuzhong Yao TAB2 Promotes the Stemness and Biological Functions of Cervical Squamous Cell Carcinoma Cells Stem Cells International |
| title | TAB2 Promotes the Stemness and Biological Functions of Cervical Squamous Cell Carcinoma Cells |
| title_full | TAB2 Promotes the Stemness and Biological Functions of Cervical Squamous Cell Carcinoma Cells |
| title_fullStr | TAB2 Promotes the Stemness and Biological Functions of Cervical Squamous Cell Carcinoma Cells |
| title_full_unstemmed | TAB2 Promotes the Stemness and Biological Functions of Cervical Squamous Cell Carcinoma Cells |
| title_short | TAB2 Promotes the Stemness and Biological Functions of Cervical Squamous Cell Carcinoma Cells |
| title_sort | tab2 promotes the stemness and biological functions of cervical squamous cell carcinoma cells |
| url | http://dx.doi.org/10.1155/2021/6550388 |
| work_keys_str_mv | AT yijiazhou tab2promotesthestemnessandbiologicalfunctionsofcervicalsquamouscellcarcinomacells AT yuandongliao tab2promotesthestemnessandbiologicalfunctionsofcervicalsquamouscellcarcinomacells AT chunyuzhang tab2promotesthestemnessandbiologicalfunctionsofcervicalsquamouscellcarcinomacells AT junxiuliu tab2promotesthestemnessandbiologicalfunctionsofcervicalsquamouscellcarcinomacells AT weiwang tab2promotesthestemnessandbiologicalfunctionsofcervicalsquamouscellcarcinomacells AT jiaminghuang tab2promotesthestemnessandbiologicalfunctionsofcervicalsquamouscellcarcinomacells AT qiqiaodu tab2promotesthestemnessandbiologicalfunctionsofcervicalsquamouscellcarcinomacells AT tianyuliu tab2promotesthestemnessandbiologicalfunctionsofcervicalsquamouscellcarcinomacells AT qiaojianzou tab2promotesthestemnessandbiologicalfunctionsofcervicalsquamouscellcarcinomacells AT huahuang tab2promotesthestemnessandbiologicalfunctionsofcervicalsquamouscellcarcinomacells AT panliu tab2promotesthestemnessandbiologicalfunctionsofcervicalsquamouscellcarcinomacells AT shiyinooi tab2promotesthestemnessandbiologicalfunctionsofcervicalsquamouscellcarcinomacells AT runchen tab2promotesthestemnessandbiologicalfunctionsofcervicalsquamouscellcarcinomacells AT mengxia tab2promotesthestemnessandbiologicalfunctionsofcervicalsquamouscellcarcinomacells AT hongyejiang tab2promotesthestemnessandbiologicalfunctionsofcervicalsquamouscellcarcinomacells AT manmanxu tab2promotesthestemnessandbiologicalfunctionsofcervicalsquamouscellcarcinomacells AT yuwenpan tab2promotesthestemnessandbiologicalfunctionsofcervicalsquamouscellcarcinomacells AT shuzhongyao tab2promotesthestemnessandbiologicalfunctionsofcervicalsquamouscellcarcinomacells |