Gliosarcoma with Primary Skull Base Invasion
Gliosarcoma is an uncommon variant of glioblastoma, which commonly demonstrates dural attachment. However, skull base invasion is rarely seen with this entity. Herein, we report a 44-year-old female patient diagnosed with primary intracranial gliosarcoma extensively invading the skull base and muscl...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Radiology |
| Online Access: | http://dx.doi.org/10.1155/2016/1762195 |
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| author | Quoc-Bao D. Nguyen Avital Perry Christopher S. Graffeo Cody L. Nesvick Aditya Raghunathan Mark E. Jentoft Brian P. O’Neill Padraig P. Morris Jonathan M. Morris Jamie J. Van Gompel |
| author_facet | Quoc-Bao D. Nguyen Avital Perry Christopher S. Graffeo Cody L. Nesvick Aditya Raghunathan Mark E. Jentoft Brian P. O’Neill Padraig P. Morris Jonathan M. Morris Jamie J. Van Gompel |
| author_sort | Quoc-Bao D. Nguyen |
| collection | DOAJ |
| description | Gliosarcoma is an uncommon variant of glioblastoma, which commonly demonstrates dural attachment. However, skull base invasion is rarely seen with this entity. Herein, we report a 44-year-old female patient diagnosed with primary intracranial gliosarcoma extensively invading the skull base and muscles of mastication. She presented to our institution with a three-month history of difficult right jaw opening and retro-orbital pressure and one week of severe right-sided postauricular headache. Head CT demonstrated a 6 cm mass with marked bony erosion. Brain MRI at a one-week interval more clearly characterized tumor extension through the right orbit and muscles of mastication, with overall growth to 7 cm and worsening midline shift. The patient underwent a right frontotemporal craniotomy for gross total resection. Pathology confirmed the diagnosis of gliosarcoma, IDH-wildtype (WHO grade IV). Her postoperative course was uneventful and she was discharged at preoperative neurologic baseline. To our knowledge, this is the third reported case of a primary intracranial gliosarcoma with direct invasion of skull base, brain parenchyma, and extracranial compartment. However, this is the first report case of primary GS invading the surrounding musculature and orbit. This case report highlights the rapid aggressiveness of gliosarcomas and further a prior undescribed radiographic and anatomic finding of skull base invasion with this entity. |
| format | Article |
| id | doaj-art-aaa367555c9a491086a497ceefb11880 |
| institution | Kabale University |
| issn | 2090-6862 2090-6870 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Radiology |
| spelling | doaj-art-aaa367555c9a491086a497ceefb118802025-02-03T05:59:56ZengWileyCase Reports in Radiology2090-68622090-68702016-01-01201610.1155/2016/17621951762195Gliosarcoma with Primary Skull Base InvasionQuoc-Bao D. Nguyen0Avital Perry1Christopher S. Graffeo2Cody L. Nesvick3Aditya Raghunathan4Mark E. Jentoft5Brian P. O’Neill6Padraig P. Morris7Jonathan M. Morris8Jamie J. Van Gompel9Texas A&M Health Science Center College of Medicine, Temple, TX, USADepartment of Neurological Surgery, Mayo Clinic, Rochester, MN, USADepartment of Neurological Surgery, Mayo Clinic, Rochester, MN, USADepartment of Neurological Surgery, Mayo Clinic, Rochester, MN, USADepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USADepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USADepartment of Neurology, Mayo Clinic, Rochester, MN, USADepartment of Radiology, Mayo Clinic, Rochester, MN, USADepartment of Radiology, Mayo Clinic, Rochester, MN, USADepartment of Neurological Surgery, Mayo Clinic, Rochester, MN, USAGliosarcoma is an uncommon variant of glioblastoma, which commonly demonstrates dural attachment. However, skull base invasion is rarely seen with this entity. Herein, we report a 44-year-old female patient diagnosed with primary intracranial gliosarcoma extensively invading the skull base and muscles of mastication. She presented to our institution with a three-month history of difficult right jaw opening and retro-orbital pressure and one week of severe right-sided postauricular headache. Head CT demonstrated a 6 cm mass with marked bony erosion. Brain MRI at a one-week interval more clearly characterized tumor extension through the right orbit and muscles of mastication, with overall growth to 7 cm and worsening midline shift. The patient underwent a right frontotemporal craniotomy for gross total resection. Pathology confirmed the diagnosis of gliosarcoma, IDH-wildtype (WHO grade IV). Her postoperative course was uneventful and she was discharged at preoperative neurologic baseline. To our knowledge, this is the third reported case of a primary intracranial gliosarcoma with direct invasion of skull base, brain parenchyma, and extracranial compartment. However, this is the first report case of primary GS invading the surrounding musculature and orbit. This case report highlights the rapid aggressiveness of gliosarcomas and further a prior undescribed radiographic and anatomic finding of skull base invasion with this entity.http://dx.doi.org/10.1155/2016/1762195 |
| spellingShingle | Quoc-Bao D. Nguyen Avital Perry Christopher S. Graffeo Cody L. Nesvick Aditya Raghunathan Mark E. Jentoft Brian P. O’Neill Padraig P. Morris Jonathan M. Morris Jamie J. Van Gompel Gliosarcoma with Primary Skull Base Invasion Case Reports in Radiology |
| title | Gliosarcoma with Primary Skull Base Invasion |
| title_full | Gliosarcoma with Primary Skull Base Invasion |
| title_fullStr | Gliosarcoma with Primary Skull Base Invasion |
| title_full_unstemmed | Gliosarcoma with Primary Skull Base Invasion |
| title_short | Gliosarcoma with Primary Skull Base Invasion |
| title_sort | gliosarcoma with primary skull base invasion |
| url | http://dx.doi.org/10.1155/2016/1762195 |
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