Fatal Fulminant Hepatic Failure from Adenovirus in Allogeneic Bone Marrow Transplant Patients
We report two cases of fatal hepatic failure in patients who received matched unrelated bone marrow transplantation. Both patients presented with high fevers, abnormal liver functions tests, and hypodense lesions in the liver by CT scan. Histologic examination of postmortem liver samples demonstrate...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2012/463569 |
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| author | Jatin M. Vyas Wayne A. Marasco |
| author_facet | Jatin M. Vyas Wayne A. Marasco |
| author_sort | Jatin M. Vyas |
| collection | DOAJ |
| description | We report two cases of fatal hepatic failure in patients who received matched unrelated bone marrow transplantation. Both patients presented with high fevers, abnormal liver functions tests, and hypodense lesions in the liver by CT scan. Histologic examination of postmortem liver samples demonstrated extensive necrosis, and immunohistochemistry was positive for adenovirus. |
| format | Article |
| id | doaj-art-aaa30245eb6246c6ac6d69fb2e714517 |
| institution | Kabale University |
| issn | 2090-6625 2090-6633 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Infectious Diseases |
| spelling | doaj-art-aaa30245eb6246c6ac6d69fb2e7145172025-02-03T05:46:50ZengWileyCase Reports in Infectious Diseases2090-66252090-66332012-01-01201210.1155/2012/463569463569Fatal Fulminant Hepatic Failure from Adenovirus in Allogeneic Bone Marrow Transplant PatientsJatin M. Vyas0Wayne A. Marasco1Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USADepartment of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Brigham and Women’s Hospital, Boston, MA 02215, USAWe report two cases of fatal hepatic failure in patients who received matched unrelated bone marrow transplantation. Both patients presented with high fevers, abnormal liver functions tests, and hypodense lesions in the liver by CT scan. Histologic examination of postmortem liver samples demonstrated extensive necrosis, and immunohistochemistry was positive for adenovirus.http://dx.doi.org/10.1155/2012/463569 |
| spellingShingle | Jatin M. Vyas Wayne A. Marasco Fatal Fulminant Hepatic Failure from Adenovirus in Allogeneic Bone Marrow Transplant Patients Case Reports in Infectious Diseases |
| title | Fatal Fulminant Hepatic Failure from Adenovirus in Allogeneic Bone Marrow Transplant Patients |
| title_full | Fatal Fulminant Hepatic Failure from Adenovirus in Allogeneic Bone Marrow Transplant Patients |
| title_fullStr | Fatal Fulminant Hepatic Failure from Adenovirus in Allogeneic Bone Marrow Transplant Patients |
| title_full_unstemmed | Fatal Fulminant Hepatic Failure from Adenovirus in Allogeneic Bone Marrow Transplant Patients |
| title_short | Fatal Fulminant Hepatic Failure from Adenovirus in Allogeneic Bone Marrow Transplant Patients |
| title_sort | fatal fulminant hepatic failure from adenovirus in allogeneic bone marrow transplant patients |
| url | http://dx.doi.org/10.1155/2012/463569 |
| work_keys_str_mv | AT jatinmvyas fatalfulminanthepaticfailurefromadenovirusinallogeneicbonemarrowtransplantpatients AT wayneamarasco fatalfulminanthepaticfailurefromadenovirusinallogeneicbonemarrowtransplantpatients |