Relaxometry network based on MRI R2⁎ mapping revealing brain iron accumulation patterns in Parkinson's disease
Background: Excessive iron accumulation in the brain has been implicated in Parkinson's disease (PD). However, the patterns and probable sequences of iron accumulation across the PD brain remain largely unknown. This study aimed to explore the sequence of iron accumulation across the PD brain u...
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Elsevier
2024-12-01
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| Series: | NeuroImage |
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| author | Weizhao Lu Tianbin Song Zhenxiang Zang Jiping Li Yuqing Zhang Jie Lu |
| author_facet | Weizhao Lu Tianbin Song Zhenxiang Zang Jiping Li Yuqing Zhang Jie Lu |
| author_sort | Weizhao Lu |
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| description | Background: Excessive iron accumulation in the brain has been implicated in Parkinson's disease (PD). However, the patterns and probable sequences of iron accumulation across the PD brain remain largely unknown. This study aimed to explore the sequence of iron accumulation across the PD brain using R2* mapping and a relaxometry covariance network (RCN) approach. Methods: R2* quantification maps were obtained from PD patients (n = 34) and healthy controls (n = 25). RCN was configured on R2* maps to identify covariance differences in iron levels between the two groups. Regions with excessive iron accumulation and large covariance changes in PD patients compared to controls were defined as propagators of iron. In the PD group, causal RCN analysis was performed on the R2* maps sequenced according to disease duration to investigate the dynamics of iron accumulations from the propagators. The associations between individual connections of the RCN and clinical information were analyzed in PD patients. Results: The left substantia nigra pars reticulata (SNpr), left substantia nigra pars compacta (SNpc), and lobule VII of the vermis (VER7) were identified as primary regions for iron accumulation and propagation (propagator). As the disease duration increased, iron accumulation in these three propagators demonstrated positive causal effects on the bilateral pallidum, bilateral gyrus rectus, right middle frontal gyrus, and medial and anterior orbitofrontal cortex (OFC). Furthermore, individual connections of VER7 with the left gyrus rectus and anterior OFC were positively associated with disease duration. Conclusions: Our results indicate that the aberrant iron accumulation in PD involves several regions, mainly starts from the SN and cerebellum and extends to the pallidum and cortices. These findings provide preliminary information on sequences of iron accumulation in PD, which may advance our understanding of the disease. |
| format | Article |
| id | doaj-art-aa8d647ba7674b6185ccc12d20bd8e8a |
| institution | OA Journals |
| issn | 1095-9572 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
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| series | NeuroImage |
| spelling | doaj-art-aa8d647ba7674b6185ccc12d20bd8e8a2025-08-20T02:07:01ZengElsevierNeuroImage1095-95722024-12-0130312094310.1016/j.neuroimage.2024.120943Relaxometry network based on MRI R2⁎ mapping revealing brain iron accumulation patterns in Parkinson's diseaseWeizhao Lu0Tianbin Song1Zhenxiang Zang2Jiping Li3Yuqing Zhang4Jie Lu5Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China; Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Xuanwu Hospital, Beijing, 100053, ChinaDepartment of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China; Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Xuanwu Hospital, Beijing, 100053, ChinaBeijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China; Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, ChinaBeijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, 100053, ChinaBeijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, 100053, ChinaDepartment of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China; Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Xuanwu Hospital, Beijing, 100053, China; Corresponding author at: Department of Radiology and Nuclear Medicine, Xuanwu Hospital, No.45 Changchun Road, Beijing, 100053, China.Background: Excessive iron accumulation in the brain has been implicated in Parkinson's disease (PD). However, the patterns and probable sequences of iron accumulation across the PD brain remain largely unknown. This study aimed to explore the sequence of iron accumulation across the PD brain using R2* mapping and a relaxometry covariance network (RCN) approach. Methods: R2* quantification maps were obtained from PD patients (n = 34) and healthy controls (n = 25). RCN was configured on R2* maps to identify covariance differences in iron levels between the two groups. Regions with excessive iron accumulation and large covariance changes in PD patients compared to controls were defined as propagators of iron. In the PD group, causal RCN analysis was performed on the R2* maps sequenced according to disease duration to investigate the dynamics of iron accumulations from the propagators. The associations between individual connections of the RCN and clinical information were analyzed in PD patients. Results: The left substantia nigra pars reticulata (SNpr), left substantia nigra pars compacta (SNpc), and lobule VII of the vermis (VER7) were identified as primary regions for iron accumulation and propagation (propagator). As the disease duration increased, iron accumulation in these three propagators demonstrated positive causal effects on the bilateral pallidum, bilateral gyrus rectus, right middle frontal gyrus, and medial and anterior orbitofrontal cortex (OFC). Furthermore, individual connections of VER7 with the left gyrus rectus and anterior OFC were positively associated with disease duration. Conclusions: Our results indicate that the aberrant iron accumulation in PD involves several regions, mainly starts from the SN and cerebellum and extends to the pallidum and cortices. These findings provide preliminary information on sequences of iron accumulation in PD, which may advance our understanding of the disease.http://www.sciencedirect.com/science/article/pii/S1053811924004403Parkinson's diseaseR2* quantificationIron accumulationRelaxometry covariance networkSubstantia nigra |
| spellingShingle | Weizhao Lu Tianbin Song Zhenxiang Zang Jiping Li Yuqing Zhang Jie Lu Relaxometry network based on MRI R2⁎ mapping revealing brain iron accumulation patterns in Parkinson's disease NeuroImage Parkinson's disease R2* quantification Iron accumulation Relaxometry covariance network Substantia nigra |
| title | Relaxometry network based on MRI R2⁎ mapping revealing brain iron accumulation patterns in Parkinson's disease |
| title_full | Relaxometry network based on MRI R2⁎ mapping revealing brain iron accumulation patterns in Parkinson's disease |
| title_fullStr | Relaxometry network based on MRI R2⁎ mapping revealing brain iron accumulation patterns in Parkinson's disease |
| title_full_unstemmed | Relaxometry network based on MRI R2⁎ mapping revealing brain iron accumulation patterns in Parkinson's disease |
| title_short | Relaxometry network based on MRI R2⁎ mapping revealing brain iron accumulation patterns in Parkinson's disease |
| title_sort | relaxometry network based on mri r2 mapping revealing brain iron accumulation patterns in parkinson s disease |
| topic | Parkinson's disease R2* quantification Iron accumulation Relaxometry covariance network Substantia nigra |
| url | http://www.sciencedirect.com/science/article/pii/S1053811924004403 |
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