Effectiveness of switching from nalfurafine to difelikefalin in patients with hemodialysis-associated pruritus: a prospective interventional study within a new treatment algorithm

Effectiveness of switching from nalfurafine to difelikefalin in patients with hemodialysis-associated pruritus: a prospective interventional study within a new treatment algorithm

Abstract Background Since June 2009, our facility has been using an internally developed treatment algorithm that facilitates a comprehensive approach to address each cause of hemodialysis-associated pruritus (HAP), wherein oral nalfurafine, a selective κ-opioid receptor (KOR) agonist, is used for p...

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Bibliographic Details
Main Authors: Naoko Takahashi, Taku Yoshizawa, Junko Kumagai, Hideki Kawanishi, Shinichiro Tsuchiya, Misaki Moriishi, Takao Masaki
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Renal Replacement Therapy
Subjects:
Hemodialysis-associated pruritus
Quality of life
Treatment algorithm
Shiratori severity score
Numerical rating scale
Difelikefalin
Online Access:https://doi.org/10.1186/s41100-025-00653-4
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