Optimizing anti-PD-1/PD-L1 therapy efficacy and fecal microbiota transplantation donor selection through gut mycobiome-based enterotype

Optimizing anti-PD-1/PD-L1 therapy efficacy and fecal microbiota transplantation donor selection through gut mycobiome-based enterotype

Summary: Immunotherapy has revolutionized cancer treatment, but response variability remains a challenge. The gut microbiome’s role in therapeutic efficacy is well established, but the impact of the gut mycobiome is less understood. Using unsupervised clustering, we identify two gut mycobiome-based...

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Main Authors: Muni Hu, Xiaoqiang Zhu, Xiaowen Huang, Li Hua, Xiaolin Lin, Hangyu Zhang, Ye Hu, Tianying Tong, Lingxi Li, Baoqin Xuan, Ying Zhao, Yilu Zhou, Jinmei Ding, Yanru Ma, Yi Jiang, Lijun Ning, Yue Zhang, Zhenyu Wang, Jing-Yuan Fang, Youwei Zhang, Xiuying Xiao, Jie Hong, Huimin Chen, Jiantao Li, Haoyan Chen
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Cell Reports
Subjects:
CP: Microbiology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725003602
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