Porphyromonas gulae and canine periodontal disease: Current understanding and future directions
Porphyromonas gulae has emerged as a notable pathogen in canine periodontal disease, akin to Porphyromonas gingivalis in human periodontitis. This review examines the initial isolation, phylogenetic analysis, habitat, host range, relationships with host health status and age, and key pathogenic dete...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Virulence |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21505594.2024.2449019 |
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| author | Kyu Hwan Kwack Eun-Young Jang Cheul Kim Young-Suk Choi Jae-Hyung Lee Ji-Hoi Moon |
| author_facet | Kyu Hwan Kwack Eun-Young Jang Cheul Kim Young-Suk Choi Jae-Hyung Lee Ji-Hoi Moon |
| author_sort | Kyu Hwan Kwack |
| collection | DOAJ |
| description | Porphyromonas gulae has emerged as a notable pathogen in canine periodontal disease, akin to Porphyromonas gingivalis in human periodontitis. This review examines the initial isolation, phylogenetic analysis, habitat, host range, relationships with host health status and age, and key pathogenic determinants, including fimbriae, proteases, citrullinating enzyme, and lipopolysaccharide. Control strategies discussed include polyphosphate to disrupt haeme/iron utilization, clindamycin with interferon alpha to reduce bacterial load and enhance the immune response, and a protease inhibitor. Further research is needed to understand strain-level diversity of virulence factors and interactions between P. gulae and other oral bacteria, particularly Fusobacterium nucleatum, a common pathogen in both dogs and humans. The potential for interspecies transmission between dogs and humans warrants further research into these interactions. Extensive in vivo studies across various breeds are crucial to validate the effectiveness of proposed treatment strategies. This review emphasizes P. gulae’s role in periodontal health and disease, setting the stage for future research and improved management of canine periodontal disease. |
| format | Article |
| id | doaj-art-aa8486f63d504a418cc068500f5595f7 |
| institution | Kabale University |
| issn | 2150-5594 2150-5608 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Virulence |
| spelling | doaj-art-aa8486f63d504a418cc068500f5595f72025-01-21T09:14:10ZengTaylor & Francis GroupVirulence2150-55942150-56082025-12-0116110.1080/21505594.2024.2449019Porphyromonas gulae and canine periodontal disease: Current understanding and future directionsKyu Hwan Kwack0Eun-Young Jang1Cheul Kim2Young-Suk Choi3Jae-Hyung Lee4Ji-Hoi Moon5Department of Oral Microbiology, College of Dentistry, Kyung Hee University, Seoul, Republic of KoreaDepartment of Oral Microbiology, College of Dentistry, Kyung Hee University, Seoul, Republic of KoreaResearch Institute of Oral Science, College of Dentistry, Gangneung-Wonju National University, Gangneung, Republic of KoreaDepartment of Dental Hygiene, Kyung-In Women’s University, Incheon, Republic of KoreaDepartment of Oral Microbiology, College of Dentistry, Kyung Hee University, Seoul, Republic of KoreaDepartment of Oral Microbiology, College of Dentistry, Kyung Hee University, Seoul, Republic of KoreaPorphyromonas gulae has emerged as a notable pathogen in canine periodontal disease, akin to Porphyromonas gingivalis in human periodontitis. This review examines the initial isolation, phylogenetic analysis, habitat, host range, relationships with host health status and age, and key pathogenic determinants, including fimbriae, proteases, citrullinating enzyme, and lipopolysaccharide. Control strategies discussed include polyphosphate to disrupt haeme/iron utilization, clindamycin with interferon alpha to reduce bacterial load and enhance the immune response, and a protease inhibitor. Further research is needed to understand strain-level diversity of virulence factors and interactions between P. gulae and other oral bacteria, particularly Fusobacterium nucleatum, a common pathogen in both dogs and humans. The potential for interspecies transmission between dogs and humans warrants further research into these interactions. Extensive in vivo studies across various breeds are crucial to validate the effectiveness of proposed treatment strategies. This review emphasizes P. gulae’s role in periodontal health and disease, setting the stage for future research and improved management of canine periodontal disease.https://www.tandfonline.com/doi/10.1080/21505594.2024.2449019Porphyromonas gulaePorphyromonas gingivaliscanineperiodontal diseaseperiodontitis |
| spellingShingle | Kyu Hwan Kwack Eun-Young Jang Cheul Kim Young-Suk Choi Jae-Hyung Lee Ji-Hoi Moon Porphyromonas gulae and canine periodontal disease: Current understanding and future directions Virulence Porphyromonas gulae Porphyromonas gingivalis canine periodontal disease periodontitis |
| title | Porphyromonas gulae and canine periodontal disease: Current understanding and future directions |
| title_full | Porphyromonas gulae and canine periodontal disease: Current understanding and future directions |
| title_fullStr | Porphyromonas gulae and canine periodontal disease: Current understanding and future directions |
| title_full_unstemmed | Porphyromonas gulae and canine periodontal disease: Current understanding and future directions |
| title_short | Porphyromonas gulae and canine periodontal disease: Current understanding and future directions |
| title_sort | porphyromonas gulae and canine periodontal disease current understanding and future directions |
| topic | Porphyromonas gulae Porphyromonas gingivalis canine periodontal disease periodontitis |
| url | https://www.tandfonline.com/doi/10.1080/21505594.2024.2449019 |
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