Synthesis, characterization, and computational evaluation of some synthesized xanthone derivatives: focus on kinase target network and biomedical properties

Synthesis, characterization, and computational evaluation of some synthesized xanthone derivatives: focus on kinase target network and biomedical properties

BackgroundXanthones are dubbed as putative lead-like molecules for cancer drug design and discovery. This study was aimed at the synthesis, characterization, and in silico target fishing of novel xanthone derivatives.MethodsThe products of reactions of xanthydrol with urea, thiourea, and thiosemicar...

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Main Authors: Wisam Taher Muslim, Layth Jasim Mohammad, Munaf M. Naji, Isaac Karimi, Matheel D. Al-Sabti, Majid Jabir, Mazin A. A. Najm, Helgi B. Schiöth
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Pharmacology
Subjects:
xanthone
total synthesis
ADMET
molecular docking
network analysis
target fishing
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1511627/full
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