The Immune Response: Targets for the Treatment of Severe Sepsis
The clinical process of severe sepsis is characterized by extreme inflammation interlinked with potent stimulation of the coagulation cascade often followed by a state of relative immune paralysis. In this paper, we will review many of the potential therapies directed at various steps along the infl...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
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| Series: | International Journal of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2012/697592 |
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| _version_ | 1832567120084336640 |
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| author | Aline M. Bernard Gordon R. Bernard |
| author_facet | Aline M. Bernard Gordon R. Bernard |
| author_sort | Aline M. Bernard |
| collection | DOAJ |
| description | The clinical process of severe sepsis is characterized by extreme inflammation interlinked with potent stimulation of the coagulation cascade often followed by a state of relative immune paralysis. In this paper, we will review many of the potential therapies directed at various steps along the inflammatory cascade from modulation of inflammatory mediators eliciting the immune response, alteration of the host's immune response in both a stimulatory and depressive manner, and taming the overexuberant coagulation response triggered by the fierce coagulation-inflammation cycle. Finally, we will discuss further opportunities for research to improve our ability to design effective therapies. |
| format | Article |
| id | doaj-art-aa7b43eac2b64b7d8d5d099dc1a8de3a |
| institution | Kabale University |
| issn | 2090-8040 2042-0099 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Inflammation |
| spelling | doaj-art-aa7b43eac2b64b7d8d5d099dc1a8de3a2025-02-03T01:02:18ZengWileyInternational Journal of Inflammation2090-80402042-00992012-01-01201210.1155/2012/697592697592The Immune Response: Targets for the Treatment of Severe SepsisAline M. Bernard0Gordon R. Bernard1Division of Critical Care, Department of Pediatrics, University of Colorado School of Medicine, 13121 E 17th Avenue, MS 8414, Aurora, CO 80045-2535, USADivision of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Medical Center North, Vanderbilt University, Room T-1208, Nashville, TN 37232, USAThe clinical process of severe sepsis is characterized by extreme inflammation interlinked with potent stimulation of the coagulation cascade often followed by a state of relative immune paralysis. In this paper, we will review many of the potential therapies directed at various steps along the inflammatory cascade from modulation of inflammatory mediators eliciting the immune response, alteration of the host's immune response in both a stimulatory and depressive manner, and taming the overexuberant coagulation response triggered by the fierce coagulation-inflammation cycle. Finally, we will discuss further opportunities for research to improve our ability to design effective therapies.http://dx.doi.org/10.1155/2012/697592 |
| spellingShingle | Aline M. Bernard Gordon R. Bernard The Immune Response: Targets for the Treatment of Severe Sepsis International Journal of Inflammation |
| title | The Immune Response: Targets for the Treatment of Severe Sepsis |
| title_full | The Immune Response: Targets for the Treatment of Severe Sepsis |
| title_fullStr | The Immune Response: Targets for the Treatment of Severe Sepsis |
| title_full_unstemmed | The Immune Response: Targets for the Treatment of Severe Sepsis |
| title_short | The Immune Response: Targets for the Treatment of Severe Sepsis |
| title_sort | immune response targets for the treatment of severe sepsis |
| url | http://dx.doi.org/10.1155/2012/697592 |
| work_keys_str_mv | AT alinembernard theimmuneresponsetargetsforthetreatmentofseveresepsis AT gordonrbernard theimmuneresponsetargetsforthetreatmentofseveresepsis AT alinembernard immuneresponsetargetsforthetreatmentofseveresepsis AT gordonrbernard immuneresponsetargetsforthetreatmentofseveresepsis |