A Review: Inflammatory Process in Alzheimer's Disease, Role of Cytokines
Alzheimer's disease (AD) is the most common neurodegenerative disorder to date. Neuropathological hallmarks are β-amyloid (Aβ) plaques and neurofibrillary tangles, but the inflammatory process has a fundamental role in the pathogenesis of AD. Inflammatory components related to AD neuroinflammat...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/756357 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832556154117423104 |
|---|---|
| author | Jose Miguel Rubio-Perez Juana Maria Morillas-Ruiz |
| author_facet | Jose Miguel Rubio-Perez Juana Maria Morillas-Ruiz |
| author_sort | Jose Miguel Rubio-Perez |
| collection | DOAJ |
| description | Alzheimer's disease (AD) is the most common neurodegenerative disorder to date. Neuropathological hallmarks are β-amyloid (Aβ) plaques and neurofibrillary tangles, but the inflammatory process has a fundamental role in the pathogenesis of AD. Inflammatory components related to AD neuroinflammation include brain cells such as microglia and astrocytes, the complement system, as well as cytokines and chemokines. Cytokines play a key role in inflammatory and anti-inflammatory processes in AD. An important factor in the onset of inflammatory process is the overexpression of interleukin (IL)-1, which produces many reactions in a vicious circle that cause dysfunction and neuronal death. Other important cytokines in neuroinflammation are IL-6 and tumor necrosis factor (TNF)-α. By contrast, other cytokines such as IL-1 receptor antagonist (IL-1ra), IL-4, IL-10, and transforming growth factor (TGF)-β can suppress both proinflammatory cytokine production and their action, subsequently protecting the brain. It has been observed in epidemiological studies that treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) decreases the risk for developing AD. Unfortunately, clinical trials of NSAIDs in AD patients have not been very fruitful. Proinflammatory responses may be countered through polyphenols. Supplementation of these natural compounds may provide a new therapeutic line of approach to this brain disorder. |
| format | Article |
| id | doaj-art-aa79e40114954094b08e265cea8b2789 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-aa79e40114954094b08e265cea8b27892025-02-03T05:46:13ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/756357756357A Review: Inflammatory Process in Alzheimer's Disease, Role of CytokinesJose Miguel Rubio-Perez0Juana Maria Morillas-Ruiz1Department of Food and Nutrition Technology, St. Anthony Catholic University, Campus de Los Jerónimos, s/n Guadalupe, 30107 Murcia, SpainDepartment of Food and Nutrition Technology, St. Anthony Catholic University, Campus de Los Jerónimos, s/n Guadalupe, 30107 Murcia, SpainAlzheimer's disease (AD) is the most common neurodegenerative disorder to date. Neuropathological hallmarks are β-amyloid (Aβ) plaques and neurofibrillary tangles, but the inflammatory process has a fundamental role in the pathogenesis of AD. Inflammatory components related to AD neuroinflammation include brain cells such as microglia and astrocytes, the complement system, as well as cytokines and chemokines. Cytokines play a key role in inflammatory and anti-inflammatory processes in AD. An important factor in the onset of inflammatory process is the overexpression of interleukin (IL)-1, which produces many reactions in a vicious circle that cause dysfunction and neuronal death. Other important cytokines in neuroinflammation are IL-6 and tumor necrosis factor (TNF)-α. By contrast, other cytokines such as IL-1 receptor antagonist (IL-1ra), IL-4, IL-10, and transforming growth factor (TGF)-β can suppress both proinflammatory cytokine production and their action, subsequently protecting the brain. It has been observed in epidemiological studies that treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) decreases the risk for developing AD. Unfortunately, clinical trials of NSAIDs in AD patients have not been very fruitful. Proinflammatory responses may be countered through polyphenols. Supplementation of these natural compounds may provide a new therapeutic line of approach to this brain disorder.http://dx.doi.org/10.1100/2012/756357 |
| spellingShingle | Jose Miguel Rubio-Perez Juana Maria Morillas-Ruiz A Review: Inflammatory Process in Alzheimer's Disease, Role of Cytokines The Scientific World Journal |
| title | A Review: Inflammatory Process in Alzheimer's Disease, Role of Cytokines |
| title_full | A Review: Inflammatory Process in Alzheimer's Disease, Role of Cytokines |
| title_fullStr | A Review: Inflammatory Process in Alzheimer's Disease, Role of Cytokines |
| title_full_unstemmed | A Review: Inflammatory Process in Alzheimer's Disease, Role of Cytokines |
| title_short | A Review: Inflammatory Process in Alzheimer's Disease, Role of Cytokines |
| title_sort | review inflammatory process in alzheimer s disease role of cytokines |
| url | http://dx.doi.org/10.1100/2012/756357 |
| work_keys_str_mv | AT josemiguelrubioperez areviewinflammatoryprocessinalzheimersdiseaseroleofcytokines AT juanamariamorillasruiz areviewinflammatoryprocessinalzheimersdiseaseroleofcytokines AT josemiguelrubioperez reviewinflammatoryprocessinalzheimersdiseaseroleofcytokines AT juanamariamorillasruiz reviewinflammatoryprocessinalzheimersdiseaseroleofcytokines |