Imaging, Histopathologic, and Treatment Nuances of Pulmonary Carcinosarcoma
A 76-year-old female with coronary artery disease, chronic obstructive pulmonary disease, diabetes mellitus type II, and 40 pack-year smoking history presented with a four-day history of cough, productive of green-yellow sputum. Chest X-ray revealed opacification of the left upper lung field, and co...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Radiology |
| Online Access: | http://dx.doi.org/10.1155/2017/8135957 |
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| author | Tyler Gleason Michael Haas Brian H. Le |
| author_facet | Tyler Gleason Michael Haas Brian H. Le |
| author_sort | Tyler Gleason |
| collection | DOAJ |
| description | A 76-year-old female with coronary artery disease, chronic obstructive pulmonary disease, diabetes mellitus type II, and 40 pack-year smoking history presented with a four-day history of cough, productive of green-yellow sputum. Chest X-ray revealed opacification of the left upper lung field, and computed tomography (CT) of the chest showed a large cavitary lesion invading the T2-T3 vertebral bodies, extending into the epidural space, giving rise to mild cord compression. Biopsy of the lesion revealed a poorly differentiated neoplasm composed of distinct epithelial and mesenchymal components, consistent with carcinosarcoma. A metastatic workup was negative. Primary lung carcinosarcoma is a rare tumour that can demonstrate an especially aggressive clinical course; diagnosis is often nuanced by limited sampling at initial presentation, especially in a setting of advanced disease and debility that precludes consideration for upfront resection or more extensive, invasive sampling. |
| format | Article |
| id | doaj-art-aa787dc7215e42028a74e3891163cd64 |
| institution | Kabale University |
| issn | 2090-6862 2090-6870 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Radiology |
| spelling | doaj-art-aa787dc7215e42028a74e3891163cd642025-02-03T01:12:10ZengWileyCase Reports in Radiology2090-68622090-68702017-01-01201710.1155/2017/81359578135957Imaging, Histopathologic, and Treatment Nuances of Pulmonary CarcinosarcomaTyler Gleason0Michael Haas1Brian H. Le2Department of Medicine, Reading Hospital, West Reading, PA 19611, USADepartment of Radiology and Radiation Oncology, Reading Hospital, West Reading, PA 19611, USADepartment of Pathology, Reading Hospital, West Reading, PA 19611, USAA 76-year-old female with coronary artery disease, chronic obstructive pulmonary disease, diabetes mellitus type II, and 40 pack-year smoking history presented with a four-day history of cough, productive of green-yellow sputum. Chest X-ray revealed opacification of the left upper lung field, and computed tomography (CT) of the chest showed a large cavitary lesion invading the T2-T3 vertebral bodies, extending into the epidural space, giving rise to mild cord compression. Biopsy of the lesion revealed a poorly differentiated neoplasm composed of distinct epithelial and mesenchymal components, consistent with carcinosarcoma. A metastatic workup was negative. Primary lung carcinosarcoma is a rare tumour that can demonstrate an especially aggressive clinical course; diagnosis is often nuanced by limited sampling at initial presentation, especially in a setting of advanced disease and debility that precludes consideration for upfront resection or more extensive, invasive sampling.http://dx.doi.org/10.1155/2017/8135957 |
| spellingShingle | Tyler Gleason Michael Haas Brian H. Le Imaging, Histopathologic, and Treatment Nuances of Pulmonary Carcinosarcoma Case Reports in Radiology |
| title | Imaging, Histopathologic, and Treatment Nuances of Pulmonary Carcinosarcoma |
| title_full | Imaging, Histopathologic, and Treatment Nuances of Pulmonary Carcinosarcoma |
| title_fullStr | Imaging, Histopathologic, and Treatment Nuances of Pulmonary Carcinosarcoma |
| title_full_unstemmed | Imaging, Histopathologic, and Treatment Nuances of Pulmonary Carcinosarcoma |
| title_short | Imaging, Histopathologic, and Treatment Nuances of Pulmonary Carcinosarcoma |
| title_sort | imaging histopathologic and treatment nuances of pulmonary carcinosarcoma |
| url | http://dx.doi.org/10.1155/2017/8135957 |
| work_keys_str_mv | AT tylergleason imaginghistopathologicandtreatmentnuancesofpulmonarycarcinosarcoma AT michaelhaas imaginghistopathologicandtreatmentnuancesofpulmonarycarcinosarcoma AT brianhle imaginghistopathologicandtreatmentnuancesofpulmonarycarcinosarcoma |