Naloxone‐associated pulmonary edema in a 3‐year‐old with opioid overdose
Abstract Background Annually, close to 5000 children under age 6 years are treated in emergency departments or admitted for care due to opioid exposures. Naloxone is effectively used to treat opioid overdose in both children and adults. Non‐cardiogenic pulmonary edema is a rare but serious adverse e...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | Journal of the American College of Emergency Physicians Open |
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| Online Access: | https://doi.org/10.1002/emp2.12740 |
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| author | Sarah Grout Madhuri Dave Roxanna Lefort |
| author_facet | Sarah Grout Madhuri Dave Roxanna Lefort |
| author_sort | Sarah Grout |
| collection | DOAJ |
| description | Abstract Background Annually, close to 5000 children under age 6 years are treated in emergency departments or admitted for care due to opioid exposures. Naloxone is effectively used to treat opioid overdose in both children and adults. Non‐cardiogenic pulmonary edema is a rare but serious adverse effect of naloxone administration that has been reported in adults. Case Report We present the case of a 3‐year‐old male with suspected opioid overdose who developed acute hypoxia due to pulmonary edema after administration of naloxone following a likely prolonged downtime. Why Should an Emergency Physician Be Aware of This? The copious fluid in the airway made for difficult intubation at a pediatric tertiary care center. Given the incidence of opioid exposures in children, clinicians should be aware of this rare, but dangerous adverse effect of naloxone and consider airway precautions and pediatric critical care availability early in the presentation. |
| format | Article |
| id | doaj-art-aa782854de1d449398a11b749c8e230c |
| institution | OA Journals |
| issn | 2688-1152 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the American College of Emergency Physicians Open |
| spelling | doaj-art-aa782854de1d449398a11b749c8e230c2025-08-20T01:59:52ZengElsevierJournal of the American College of Emergency Physicians Open2688-11522022-06-0133n/an/a10.1002/emp2.12740Naloxone‐associated pulmonary edema in a 3‐year‐old with opioid overdoseSarah Grout0Madhuri Dave1Roxanna Lefort2Department of Pediatrics Indiana University School of Medicine Indianapolis Indiana USADivision of Pediatric Emergency Medicine Department of Emergency Medicine Indiana University School of Medicine Indianapolis Indiana USADivision of Pediatric Emergency Medicine Department of Emergency Medicine Indiana University School of Medicine Indianapolis Indiana USAAbstract Background Annually, close to 5000 children under age 6 years are treated in emergency departments or admitted for care due to opioid exposures. Naloxone is effectively used to treat opioid overdose in both children and adults. Non‐cardiogenic pulmonary edema is a rare but serious adverse effect of naloxone administration that has been reported in adults. Case Report We present the case of a 3‐year‐old male with suspected opioid overdose who developed acute hypoxia due to pulmonary edema after administration of naloxone following a likely prolonged downtime. Why Should an Emergency Physician Be Aware of This? The copious fluid in the airway made for difficult intubation at a pediatric tertiary care center. Given the incidence of opioid exposures in children, clinicians should be aware of this rare, but dangerous adverse effect of naloxone and consider airway precautions and pediatric critical care availability early in the presentation.https://doi.org/10.1002/emp2.12740fentanylintubationopiateopiate overdosepediatric emergencytoxicologypulmonary edema |
| spellingShingle | Sarah Grout Madhuri Dave Roxanna Lefort Naloxone‐associated pulmonary edema in a 3‐year‐old with opioid overdose Journal of the American College of Emergency Physicians Open fentanyl intubation opiate opiate overdose pediatric emergencytoxicology pulmonary edema |
| title | Naloxone‐associated pulmonary edema in a 3‐year‐old with opioid overdose |
| title_full | Naloxone‐associated pulmonary edema in a 3‐year‐old with opioid overdose |
| title_fullStr | Naloxone‐associated pulmonary edema in a 3‐year‐old with opioid overdose |
| title_full_unstemmed | Naloxone‐associated pulmonary edema in a 3‐year‐old with opioid overdose |
| title_short | Naloxone‐associated pulmonary edema in a 3‐year‐old with opioid overdose |
| title_sort | naloxone associated pulmonary edema in a 3 year old with opioid overdose |
| topic | fentanyl intubation opiate opiate overdose pediatric emergencytoxicology pulmonary edema |
| url | https://doi.org/10.1002/emp2.12740 |
| work_keys_str_mv | AT sarahgrout naloxoneassociatedpulmonaryedemaina3yearoldwithopioidoverdose AT madhuridave naloxoneassociatedpulmonaryedemaina3yearoldwithopioidoverdose AT roxannalefort naloxoneassociatedpulmonaryedemaina3yearoldwithopioidoverdose |