NKT Cells in Sepsis
Sepsis is currently a leading cause of death in hospital intensive care units. Previous studies suggest that the pathophysiology of sepsis involves the hyperactivation of complex proinflammatory cascades that include the activation of various immune cells and the exuberant secretion of proinflammato...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2010/414650 |
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| _version_ | 1832559783774781440 |
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| author | Briana Leung Hobart W. Harris |
| author_facet | Briana Leung Hobart W. Harris |
| author_sort | Briana Leung |
| collection | DOAJ |
| description | Sepsis is currently a leading cause of death in hospital intensive care units. Previous studies suggest that the pathophysiology of sepsis involves the hyperactivation of complex proinflammatory cascades that include the activation of various immune cells and the exuberant secretion of proinflammatory cytokines by these cells. Natural killer T-cells (NKTs) are a sublineage of T cells that share characteristics of conventional T cells and NK cells and bridge innate and adaptive immunity. More recently, NKT cells have been implicated in microbial immunity, including the onset of sepsis. Moreover, apolipoprotein E (apoE), a component of triglyceride-rich lipoproteins, has been shown to be protective in endotoxemia and gram-negative infections in addition to its well-known role in lipid metabolism. Here, we will review the role of NKT cells in sepsis and septic shock, the immunoregulatory role of apoE in the host immune response to infection, and propose a mechanism for this immunoregulation. |
| format | Article |
| id | doaj-art-aa6e5f6a32fb448aa3759d154dd720c2 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-aa6e5f6a32fb448aa3759d154dd720c22025-02-03T01:29:14ZengWileyClinical and Developmental Immunology1740-25221740-25302010-01-01201010.1155/2010/414650414650NKT Cells in SepsisBriana Leung0Hobart W. Harris1Department of Surgery, University of California, San Francisco, San Francisco, CA 94143, USADepartment of Surgery, University of California, San Francisco, San Francisco, CA 94143, USASepsis is currently a leading cause of death in hospital intensive care units. Previous studies suggest that the pathophysiology of sepsis involves the hyperactivation of complex proinflammatory cascades that include the activation of various immune cells and the exuberant secretion of proinflammatory cytokines by these cells. Natural killer T-cells (NKTs) are a sublineage of T cells that share characteristics of conventional T cells and NK cells and bridge innate and adaptive immunity. More recently, NKT cells have been implicated in microbial immunity, including the onset of sepsis. Moreover, apolipoprotein E (apoE), a component of triglyceride-rich lipoproteins, has been shown to be protective in endotoxemia and gram-negative infections in addition to its well-known role in lipid metabolism. Here, we will review the role of NKT cells in sepsis and septic shock, the immunoregulatory role of apoE in the host immune response to infection, and propose a mechanism for this immunoregulation.http://dx.doi.org/10.1155/2010/414650 |
| spellingShingle | Briana Leung Hobart W. Harris NKT Cells in Sepsis Clinical and Developmental Immunology |
| title | NKT Cells in Sepsis |
| title_full | NKT Cells in Sepsis |
| title_fullStr | NKT Cells in Sepsis |
| title_full_unstemmed | NKT Cells in Sepsis |
| title_short | NKT Cells in Sepsis |
| title_sort | nkt cells in sepsis |
| url | http://dx.doi.org/10.1155/2010/414650 |
| work_keys_str_mv | AT brianaleung nktcellsinsepsis AT hobartwharris nktcellsinsepsis |