Tobacco smoke exposure is a driver of altered oxidative stress response and immunity in head and neck cancer

Tobacco smoke exposure is a driver of altered oxidative stress response and immunity in head and neck cancer

Abstract Background Exposomes are critical drivers of carcinogenesis. However, how they modulate tumor behavior remains unclear. Extensive clinical data show cigarette smoke to be a key exposome that promotes aggressive tumors, higher rates of metastasis, reduced response to chemoradiotherapy, and s...

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Main Authors: Yang Li, Pedram Yadollahi, Fonma N. Essien, Vasanta Putluri, Chandra Shekar R. Ambati, Karthik Reddy Kami Reddy, Abu Hena Mostafa Kamal, Nagireddy Putluri, Lama M. Abdurrahman, Maria E. Ruiz Echartea, Keenan J. Ernste, Akshar J. Trivedi, Jonathan Vazquez-Perez, William H. Hudson, William K. Decker, Rutulkumar Patel, Abdullah. A. Osman, Farrah Kheradmand, Stephen Y. Lai, Jeffrey N. Myers, Heath D. Skinner, Cristian Coarfa, Kwangwon Lee, Antrix Jain, Anna Malovannaya, Mitchell J. Frederick, Vlad C. Sandulache
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Translational Medicine
Subjects:
Tobacco
Nrf2
Oxidative stress
Keap1
Glutathione
PDL1
Online Access:https://doi.org/10.1186/s12967-025-06258-z
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