The Orphan Nuclear Receptor 4A1: A Potential New Therapeutic Target for Metabolic Diseases
Orphan nuclear receptor 4A1 (NR4A1) is a transcriptional factor of the nuclear orphan receptor (NR4A) superfamily that has sparked interest across different research fields in recent years. Several studies have demonstrated that ligand-independent NR4A1 is an immediate-early response gene and the pr...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2018/9363461 |
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| author | Lei Zhang Qun Wang Wen Liu Fangyan Liu Ailing Ji Yanzhang Li |
| author_facet | Lei Zhang Qun Wang Wen Liu Fangyan Liu Ailing Ji Yanzhang Li |
| author_sort | Lei Zhang |
| collection | DOAJ |
| description | Orphan nuclear receptor 4A1 (NR4A1) is a transcriptional factor of the nuclear orphan receptor (NR4A) superfamily that has sparked interest across different research fields in recent years. Several studies have demonstrated that ligand-independent NR4A1 is an immediate-early response gene and the protein product is rapidly induced by a variety of stimuli. Hyperfunction or dysfunction of NR4A1 is implicated in various metabolic processes, including carbohydrate metabolism, lipid metabolism, and energy balance, in major metabolic tissues, such as liver, skeletal muscle, pancreatic tissues, and adipose tissues. No endogenous ligands for NR4A1 have been identified, but numerous compounds that bind and activate or inactivate nuclear NR4A1 or induce cytoplasmic localization of NR4A1 have been identified. This review summarizes recent advances in our understanding of the molecular biology and physiological functions of NR4A1. And we focus on the physiological functions of NR4A1 receptor to the development of the metabolic diseases, with a special focus on the impact on carbohydrate and lipid metabolism in skeletal muscle, liver, adipose tissue, and islet. |
| format | Article |
| id | doaj-art-aa670e5bf4604c46902c98910dbdada3 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-aa670e5bf4604c46902c98910dbdada32025-02-03T01:25:31ZengWileyJournal of Diabetes Research2314-67452314-67532018-01-01201810.1155/2018/93634619363461The Orphan Nuclear Receptor 4A1: A Potential New Therapeutic Target for Metabolic DiseasesLei Zhang0Qun Wang1Wen Liu2Fangyan Liu3Ailing Ji4Yanzhang Li5Henan University School of Basic Medical Sciences, Henan University Joint National Laboratory for Antibody Drug Engineering, Kaifeng 475004, ChinaHenan University School of Basic Medical Sciences, Henan University Joint National Laboratory for Antibody Drug Engineering, Kaifeng 475004, ChinaHenan University School of Basic Medical Sciences, Henan University Joint National Laboratory for Antibody Drug Engineering, Kaifeng 475004, ChinaHenan University School of Basic Medical Sciences, Henan University Joint National Laboratory for Antibody Drug Engineering, Kaifeng 475004, ChinaHenan University School of Basic Medical Sciences, Henan University Joint National Laboratory for Antibody Drug Engineering, Kaifeng 475004, ChinaHenan University School of Basic Medical Sciences, Henan University Joint National Laboratory for Antibody Drug Engineering, Kaifeng 475004, ChinaOrphan nuclear receptor 4A1 (NR4A1) is a transcriptional factor of the nuclear orphan receptor (NR4A) superfamily that has sparked interest across different research fields in recent years. Several studies have demonstrated that ligand-independent NR4A1 is an immediate-early response gene and the protein product is rapidly induced by a variety of stimuli. Hyperfunction or dysfunction of NR4A1 is implicated in various metabolic processes, including carbohydrate metabolism, lipid metabolism, and energy balance, in major metabolic tissues, such as liver, skeletal muscle, pancreatic tissues, and adipose tissues. No endogenous ligands for NR4A1 have been identified, but numerous compounds that bind and activate or inactivate nuclear NR4A1 or induce cytoplasmic localization of NR4A1 have been identified. This review summarizes recent advances in our understanding of the molecular biology and physiological functions of NR4A1. And we focus on the physiological functions of NR4A1 receptor to the development of the metabolic diseases, with a special focus on the impact on carbohydrate and lipid metabolism in skeletal muscle, liver, adipose tissue, and islet.http://dx.doi.org/10.1155/2018/9363461 |
| spellingShingle | Lei Zhang Qun Wang Wen Liu Fangyan Liu Ailing Ji Yanzhang Li The Orphan Nuclear Receptor 4A1: A Potential New Therapeutic Target for Metabolic Diseases Journal of Diabetes Research |
| title | The Orphan Nuclear Receptor 4A1: A Potential New Therapeutic Target for Metabolic Diseases |
| title_full | The Orphan Nuclear Receptor 4A1: A Potential New Therapeutic Target for Metabolic Diseases |
| title_fullStr | The Orphan Nuclear Receptor 4A1: A Potential New Therapeutic Target for Metabolic Diseases |
| title_full_unstemmed | The Orphan Nuclear Receptor 4A1: A Potential New Therapeutic Target for Metabolic Diseases |
| title_short | The Orphan Nuclear Receptor 4A1: A Potential New Therapeutic Target for Metabolic Diseases |
| title_sort | orphan nuclear receptor 4a1 a potential new therapeutic target for metabolic diseases |
| url | http://dx.doi.org/10.1155/2018/9363461 |
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