Sex-specific association between maternal childhood adversities and offspring’s weight gain in a Brazilian cohort
Abstract Maternal adverse childhood experiences (ACEs) are linked to negative health and developmental outcomes in offspring. However, whether maternal ACEs influence infant weight gain in the first months of life, and if this effect differs by infant sex, remains unclear. This study included 352 fu...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-025-87078-5 |
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| author | Vinicius Oliveira Santana Aline Camargo Ramos Hugo Cogo-Moreira Célia Maria Araújo Barbara Shibuya Alves Lucas Ribeiro Aline Lodi Ana Carolina Coelho Milani Ivaldo Silva Cristiane S. Duarte Jonathan Posner Andrea Parolin Jackowski |
| author_facet | Vinicius Oliveira Santana Aline Camargo Ramos Hugo Cogo-Moreira Célia Maria Araújo Barbara Shibuya Alves Lucas Ribeiro Aline Lodi Ana Carolina Coelho Milani Ivaldo Silva Cristiane S. Duarte Jonathan Posner Andrea Parolin Jackowski |
| author_sort | Vinicius Oliveira Santana |
| collection | DOAJ |
| description | Abstract Maternal adverse childhood experiences (ACEs) are linked to negative health and developmental outcomes in offspring. However, whether maternal ACEs influence infant weight gain in the first months of life, and if this effect differs by infant sex, remains unclear. This study included 352 full-term newborns from low-risk pregnancies and their mothers in low-income settings in Brazil. Anthropometric data (weight, length, head circumference) and other information (feeding type, offspring sex, family income) were collected at delivery (W0), discharge (W1), and up to 8 weeks postpartum (W2). ACEs were assessed using the CDC-Kaiser Questionnaire, and weight gain was calculated as the difference between W2 and W1, divided by the number of days between measurements. The association between maternal ACEs and offspring weight gain was positive only in male offspring (unstandardized coefficient (male) = 1.82, SE = 0.438, p < 0.001); for each 1-point increase in the ACEs score (e.g., from 0 to 1), weight gain increased by 1.8 g/day. These findings indicate that maternal ACEs are associated with increased weight gain in male infants during the first two months of life, potentially increasing the risk of future obesity. Further research is required to investigate the underlying biological mechanisms and their neurodevelopmental implications. |
| format | Article |
| id | doaj-art-aa65d21d69964b858871ad9b5cab8397 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-aa65d21d69964b858871ad9b5cab83972025-01-26T12:27:14ZengNature PortfolioScientific Reports2045-23222025-01-011511910.1038/s41598-025-87078-5Sex-specific association between maternal childhood adversities and offspring’s weight gain in a Brazilian cohortVinicius Oliveira Santana0Aline Camargo Ramos1Hugo Cogo-Moreira2Célia Maria Araújo3Barbara Shibuya Alves4Lucas Ribeiro5Aline Lodi6Ana Carolina Coelho Milani7Ivaldo Silva8Cristiane S. Duarte9Jonathan Posner10Andrea Parolin Jackowski11Laboratory of Integrative Neuroscience (LiNC), Universidade Federal de São PauloLaboratory of Integrative Neuroscience (LiNC), Universidade Federal de São PauloDepartment of Education, Information and Communications Technology (ICT) and Learning, Østfold University CollegeLaboratory of Integrative Neuroscience (LiNC), Universidade Federal de São PauloLaboratory of Integrative Neuroscience (LiNC), Universidade Federal de São PauloLaboratory of Integrative Neuroscience (LiNC), Universidade Federal de São PauloLaboratory of Integrative Neuroscience (LiNC), Universidade Federal de São PauloLaboratory of Integrative Neuroscience (LiNC), Universidade Federal de São PauloDepartment of Gynaecology, Universidade Federal de São PauloNew York State Psychiatric Institute, Columbia University Irving Medical CenterDuke University Medical CenterLaboratory of Integrative Neuroscience (LiNC), Universidade Federal de São PauloAbstract Maternal adverse childhood experiences (ACEs) are linked to negative health and developmental outcomes in offspring. However, whether maternal ACEs influence infant weight gain in the first months of life, and if this effect differs by infant sex, remains unclear. This study included 352 full-term newborns from low-risk pregnancies and their mothers in low-income settings in Brazil. Anthropometric data (weight, length, head circumference) and other information (feeding type, offspring sex, family income) were collected at delivery (W0), discharge (W1), and up to 8 weeks postpartum (W2). ACEs were assessed using the CDC-Kaiser Questionnaire, and weight gain was calculated as the difference between W2 and W1, divided by the number of days between measurements. The association between maternal ACEs and offspring weight gain was positive only in male offspring (unstandardized coefficient (male) = 1.82, SE = 0.438, p < 0.001); for each 1-point increase in the ACEs score (e.g., from 0 to 1), weight gain increased by 1.8 g/day. These findings indicate that maternal ACEs are associated with increased weight gain in male infants during the first two months of life, potentially increasing the risk of future obesity. Further research is required to investigate the underlying biological mechanisms and their neurodevelopmental implications.https://doi.org/10.1038/s41598-025-87078-5Sex differencesAdverse childhood experiencesWeight gainObesityNeurodevelopment |
| spellingShingle | Vinicius Oliveira Santana Aline Camargo Ramos Hugo Cogo-Moreira Célia Maria Araújo Barbara Shibuya Alves Lucas Ribeiro Aline Lodi Ana Carolina Coelho Milani Ivaldo Silva Cristiane S. Duarte Jonathan Posner Andrea Parolin Jackowski Sex-specific association between maternal childhood adversities and offspring’s weight gain in a Brazilian cohort Scientific Reports Sex differences Adverse childhood experiences Weight gain Obesity Neurodevelopment |
| title | Sex-specific association between maternal childhood adversities and offspring’s weight gain in a Brazilian cohort |
| title_full | Sex-specific association between maternal childhood adversities and offspring’s weight gain in a Brazilian cohort |
| title_fullStr | Sex-specific association between maternal childhood adversities and offspring’s weight gain in a Brazilian cohort |
| title_full_unstemmed | Sex-specific association between maternal childhood adversities and offspring’s weight gain in a Brazilian cohort |
| title_short | Sex-specific association between maternal childhood adversities and offspring’s weight gain in a Brazilian cohort |
| title_sort | sex specific association between maternal childhood adversities and offspring s weight gain in a brazilian cohort |
| topic | Sex differences Adverse childhood experiences Weight gain Obesity Neurodevelopment |
| url | https://doi.org/10.1038/s41598-025-87078-5 |
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