Immunotherapy-Induced Overlap Syndrome: Myositis, Myasthenia Gravis, and Myocarditis—A Case Series
Immune checkpoint inhibitors (ICI) are monoclonal antibodies that target immune checkpoint inhibitory receptors. They have revolutionised cancer treatment but can be associated with a wide range of adverse side effects. Rarely, they can be associated with the triad of myositis, myasthenia gravis, an...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2024/5399073 |
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| _version_ | 1832553143518363648 |
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| author | Nikhil Aggarwal Diletta Bianchini Rosemeen Parkar Jennifer Turner |
| author_facet | Nikhil Aggarwal Diletta Bianchini Rosemeen Parkar Jennifer Turner |
| author_sort | Nikhil Aggarwal |
| collection | DOAJ |
| description | Immune checkpoint inhibitors (ICI) are monoclonal antibodies that target immune checkpoint inhibitory receptors. They have revolutionised cancer treatment but can be associated with a wide range of adverse side effects. Rarely, they can be associated with the triad of myositis, myasthenia gravis, and myocarditis or overlap syndrome. Prompt recognition and early intervention are needed to treat these potentially life-threatening conditions. We report a case series of patients with ICI-related overlap syndrome, including the first with avelumab, and discuss the current management guidelines. |
| format | Article |
| id | doaj-art-aa658a242386477384840deddb7b6eb9 |
| institution | Kabale University |
| issn | 1687-9635 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-aa658a242386477384840deddb7b6eb92025-02-03T05:55:20ZengWileyCase Reports in Medicine1687-96352024-01-01202410.1155/2024/5399073Immunotherapy-Induced Overlap Syndrome: Myositis, Myasthenia Gravis, and Myocarditis—A Case SeriesNikhil Aggarwal0Diletta Bianchini1Rosemeen Parkar2Jennifer Turner3Kent Oncology CentreKent Oncology CentreKent Oncology CentreKent Oncology CentreImmune checkpoint inhibitors (ICI) are monoclonal antibodies that target immune checkpoint inhibitory receptors. They have revolutionised cancer treatment but can be associated with a wide range of adverse side effects. Rarely, they can be associated with the triad of myositis, myasthenia gravis, and myocarditis or overlap syndrome. Prompt recognition and early intervention are needed to treat these potentially life-threatening conditions. We report a case series of patients with ICI-related overlap syndrome, including the first with avelumab, and discuss the current management guidelines.http://dx.doi.org/10.1155/2024/5399073 |
| spellingShingle | Nikhil Aggarwal Diletta Bianchini Rosemeen Parkar Jennifer Turner Immunotherapy-Induced Overlap Syndrome: Myositis, Myasthenia Gravis, and Myocarditis—A Case Series Case Reports in Medicine |
| title | Immunotherapy-Induced Overlap Syndrome: Myositis, Myasthenia Gravis, and Myocarditis—A Case Series |
| title_full | Immunotherapy-Induced Overlap Syndrome: Myositis, Myasthenia Gravis, and Myocarditis—A Case Series |
| title_fullStr | Immunotherapy-Induced Overlap Syndrome: Myositis, Myasthenia Gravis, and Myocarditis—A Case Series |
| title_full_unstemmed | Immunotherapy-Induced Overlap Syndrome: Myositis, Myasthenia Gravis, and Myocarditis—A Case Series |
| title_short | Immunotherapy-Induced Overlap Syndrome: Myositis, Myasthenia Gravis, and Myocarditis—A Case Series |
| title_sort | immunotherapy induced overlap syndrome myositis myasthenia gravis and myocarditis a case series |
| url | http://dx.doi.org/10.1155/2024/5399073 |
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