Green Synthesis of Bioactive CuO@Fe3 O4 @Walnut Shell Nanocomposite Using Crataegus azarolus Var. aronia L. Extract and its Antivasoconstrictive Action on Rat’s Aortic Smooth Muscle

Green Synthesis of Bioactive CuO@Fe3 O4 @Walnut Shell Nanocomposite Using Crataegus azarolus Var. aronia L. Extract and its Antivasoconstrictive Action on Rat’s Aortic Smooth Muscle

The antioxidant potential of Crataegus azarolus Var. aronia aqueous extract was used as reducing and stabilizing media to the green synthesis of bioactive CuO@Fe3O4@Walnut shell nanocomposite (NCs). The ability of the plant extract as bioreducing medium was proved using Fourier-transform infrared sp...

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Bibliographic Details
Main Author: Sarbast A. Mahmud
Format: Article
Language:English
Published: Erbil Polytechnic University 2021-06-01
Series:Polytechnic Journal
Subjects:
aortic smooth muscle;
crataegus aronia;
green synthesis;
nanocomposite
Online Access:https://polytechnic-journal.epu.edu.iq/home/vol11/iss1/21
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Summary:The antioxidant potential of Crataegus azarolus Var. aronia aqueous extract was used as reducing and stabilizing media to the green synthesis of bioactive CuO@Fe3O4@Walnut shell nanocomposite (NCs). The ability of the plant extract as bioreducing medium was proved using Fourier-transform infrared spectroscopy and ultraviolet–visible spectroscopy. While, the structural identification of synthesized CuO@Fe3O4@Walnut shell NCs was proved using the scanning electron microscopy, electron dispersive spectroscopy, elemental mapping, and point analysis. Then, the antivasoconstriction effects of CuO@ Fe3O4@Walnut shell NCs (5*10−2 mg/ ml) and (1*10−1 mg/ ml) on rats isolated thoracic aortic smooth muscle cells were studied. Green synthesized CuO@Fe3O4@Walnut shell NCs showed effective antivasoconstriction activity against norepinephrine (NE) (1*10−9–10−4 M) induced contraction in endothelium-intact and endothelium-denuded rats aortic smooth muscle. In conclusion, the aqueous extract of C. aronia acts as potential reducing and stabilizing media to the green synthesis of bioactive CuO@Fe3O4@Walnut shell NCs and the NCs play an important role against contractile effects of NE on rats’ aortic smooth muscle.
ISSN:2707-7799

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