cGAS-STING targeting offers therapy choice in lung diseases

cGAS-STING targeting offers therapy choice in lung diseases

Abstract Cyclic GMP/AMP (cGAMP) synthase (cGAS), along with the endoplasmic reticulum (ER)-associated stimulator of interferon genes (STING), are crucial elements of the type 1 interferon response. cGAS senses microbial DNA and self-DNA, labeling cGAS-STING as a crucial mechanism in autoimmunity, st...

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Bibliographic Details
Main Authors: Yu Wang, Xuan Zhang, Weixue Wang, Yi Zhang, Joshua S. Fleishman, Hongquan Wang
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Biology Direct
Subjects:
cGAS
STING
Antagonist
Lung diseases
Online Access:https://doi.org/10.1186/s13062-025-00611-4
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