Interferon Tau Affects Mouse Intestinal Microbiota and Expression of IL-17
This study was conducted to explore the effects of interferon tau (IFNT) on the intestinal microbiota and expression of interleukin 17 (IL-17) in the intestine of mice. IFNT supplementation increased microbial diversity in the jejunum and ileum but decreased microbial diversity in the feces. IFNT su...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/2839232 |
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| author | Wenkai Ren Shuai Chen Liwen Zhang Gang Liu Tarique Hussain Xiao Hao Jie Yin Jielin Duan Bie Tan Guoyao Wu Fuller W. Bazer Yulong Yin |
| author_facet | Wenkai Ren Shuai Chen Liwen Zhang Gang Liu Tarique Hussain Xiao Hao Jie Yin Jielin Duan Bie Tan Guoyao Wu Fuller W. Bazer Yulong Yin |
| author_sort | Wenkai Ren |
| collection | DOAJ |
| description | This study was conducted to explore the effects of interferon tau (IFNT) on the intestinal microbiota and expression of interleukin 17 (IL-17) in the intestine of mice. IFNT supplementation increased microbial diversity in the jejunum and ileum but decreased microbial diversity in the feces. IFNT supplementation influenced the composition of the intestinal microbiota as follows: (1) decreasing the percentage of Firmicutes and increasing Bacteroidetes in the jejunum and ileum; (2) enhancing the percentage of Firmicutes but decreasing Bacteroidetes in the colon and feces; (3) decreasing Lactobacillus in the jejunum and ileum; (4) increasing the percentage of Blautia, Bacteroides, Alloprevotella, and Lactobacillus in the colon; and (5) increasing the percentage of Lactobacillus, Bacteroides, and Allobaculum, while decreasing Blautia in the feces. Also, IFNT supplementation decreased the expression of IL-17 in the intestines of normal mice and of an intestinal pathogen infected mice. In conclusion, IFNT supplementation modulates the intestinal microbiota and intestinal IL-17 expression, indicating the applicability of IFNT to treat the intestinal diseases involving IL-17 expression and microbiota. |
| format | Article |
| id | doaj-art-aa58c99538b7412daf058386d6d2c5a9 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-aa58c99538b7412daf058386d6d2c5a92025-02-03T01:30:17ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/28392322839232Interferon Tau Affects Mouse Intestinal Microbiota and Expression of IL-17Wenkai Ren0Shuai Chen1Liwen Zhang2Gang Liu3Tarique Hussain4Xiao Hao5Jie Yin6Jielin Duan7Bie Tan8Guoyao Wu9Fuller W. Bazer10Yulong Yin11Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Observation and Experiment Station of Animal Nutrition and Feed Science in South-Central China, Ministry of Agriculture, Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, Changsha, Hunan 410125, ChinaKey Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Observation and Experiment Station of Animal Nutrition and Feed Science in South-Central China, Ministry of Agriculture, Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, Changsha, Hunan 410125, ChinaJinan First People’s Hospital, Shandong 250011, ChinaKey Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Observation and Experiment Station of Animal Nutrition and Feed Science in South-Central China, Ministry of Agriculture, Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, Changsha, Hunan 410125, ChinaKey Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Observation and Experiment Station of Animal Nutrition and Feed Science in South-Central China, Ministry of Agriculture, Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, Changsha, Hunan 410125, ChinaKey Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Observation and Experiment Station of Animal Nutrition and Feed Science in South-Central China, Ministry of Agriculture, Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, Changsha, Hunan 410125, ChinaKey Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Observation and Experiment Station of Animal Nutrition and Feed Science in South-Central China, Ministry of Agriculture, Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, Changsha, Hunan 410125, ChinaKey Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Observation and Experiment Station of Animal Nutrition and Feed Science in South-Central China, Ministry of Agriculture, Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, Changsha, Hunan 410125, ChinaKey Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Observation and Experiment Station of Animal Nutrition and Feed Science in South-Central China, Ministry of Agriculture, Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, Changsha, Hunan 410125, ChinaDepartment of Animal Science, Texas A&M University, 2471 TAMU, College Station, TX 77843-2471, USADepartment of Animal Science, Texas A&M University, 2471 TAMU, College Station, TX 77843-2471, USAKey Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Observation and Experiment Station of Animal Nutrition and Feed Science in South-Central China, Ministry of Agriculture, Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, Changsha, Hunan 410125, ChinaThis study was conducted to explore the effects of interferon tau (IFNT) on the intestinal microbiota and expression of interleukin 17 (IL-17) in the intestine of mice. IFNT supplementation increased microbial diversity in the jejunum and ileum but decreased microbial diversity in the feces. IFNT supplementation influenced the composition of the intestinal microbiota as follows: (1) decreasing the percentage of Firmicutes and increasing Bacteroidetes in the jejunum and ileum; (2) enhancing the percentage of Firmicutes but decreasing Bacteroidetes in the colon and feces; (3) decreasing Lactobacillus in the jejunum and ileum; (4) increasing the percentage of Blautia, Bacteroides, Alloprevotella, and Lactobacillus in the colon; and (5) increasing the percentage of Lactobacillus, Bacteroides, and Allobaculum, while decreasing Blautia in the feces. Also, IFNT supplementation decreased the expression of IL-17 in the intestines of normal mice and of an intestinal pathogen infected mice. In conclusion, IFNT supplementation modulates the intestinal microbiota and intestinal IL-17 expression, indicating the applicability of IFNT to treat the intestinal diseases involving IL-17 expression and microbiota.http://dx.doi.org/10.1155/2016/2839232 |
| spellingShingle | Wenkai Ren Shuai Chen Liwen Zhang Gang Liu Tarique Hussain Xiao Hao Jie Yin Jielin Duan Bie Tan Guoyao Wu Fuller W. Bazer Yulong Yin Interferon Tau Affects Mouse Intestinal Microbiota and Expression of IL-17 Mediators of Inflammation |
| title | Interferon Tau Affects Mouse Intestinal Microbiota and Expression of IL-17 |
| title_full | Interferon Tau Affects Mouse Intestinal Microbiota and Expression of IL-17 |
| title_fullStr | Interferon Tau Affects Mouse Intestinal Microbiota and Expression of IL-17 |
| title_full_unstemmed | Interferon Tau Affects Mouse Intestinal Microbiota and Expression of IL-17 |
| title_short | Interferon Tau Affects Mouse Intestinal Microbiota and Expression of IL-17 |
| title_sort | interferon tau affects mouse intestinal microbiota and expression of il 17 |
| url | http://dx.doi.org/10.1155/2016/2839232 |
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