Targeted nanoliposomes for precision rheumatoid arthritis therapy: a review on mechanisms and in vivo potential
Rheumatoid arthritis (RA) is an inflammatory immune-triggered disease that causes synovitis, cartilage degradation, and joint injury. In nanotechnology, conventional liposomes were extensively investigated for RA. However, they frequently undergo rapid clearance, reducing circulation time and therap...
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| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Drug Delivery |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/10717544.2025.2459772 |
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| author | Rushikesh Girase Nayan A. Gujarathi Amey Sukhia Sri Sai Nikitha Kota Tulshidas S. Patil Abhijeet A. Aher Yogeeta O. Agrawal Shreesh Ojha Charu Sharma Sameer N. Goyal |
| author_facet | Rushikesh Girase Nayan A. Gujarathi Amey Sukhia Sri Sai Nikitha Kota Tulshidas S. Patil Abhijeet A. Aher Yogeeta O. Agrawal Shreesh Ojha Charu Sharma Sameer N. Goyal |
| author_sort | Rushikesh Girase |
| collection | DOAJ |
| description | Rheumatoid arthritis (RA) is an inflammatory immune-triggered disease that causes synovitis, cartilage degradation, and joint injury. In nanotechnology, conventional liposomes were extensively investigated for RA. However, they frequently undergo rapid clearance, reducing circulation time and therapeutic efficacy. Additionally, their stability in the bloodstream is often compromised, resulting in premature drug release. The current review explores the potential of targeted liposomal-based nanosystems in the treatment of RA. It highlights the pathophysiology of RA, explores selective targeting sites, and elucidates diverse mechanisms of novel liposomal types and their applications. Furthermore, the targeting strategies of pH-sensitive, flexible, surface-modified, PEGylated, acoustic, ROS-mediated, and biofunctionalized liposomes are addressed. Targeted nanoliposomes showed potential in precisely delivering drugs to CD44, SR-A, FR-β, FLS, and toll-like receptors through the high affinity of ligands. In vitro studies interpreted stable release profiles and improved stability. Ex vivo studies on skin demonstrated that ultradeformable and glycerol-conjugated liposomes enhanced drug penetrability. In vivo experiments for liposomal types in the arthritis rat model depicted remarkable efficacy in reducing joint swelling, pro-inflammatory cytokines, and synovial hyperplasia. In conclusion, these targeted liposomes represented a significant leap forward in drug delivery, offering effective therapeutic options for RA. In the future, integrating these advanced liposomes with artificial intelligence, immunotherapy, and precision medicine holds great promise. |
| format | Article |
| id | doaj-art-aa588ad3086f433aa65b3c4b078f3dc7 |
| institution | Kabale University |
| issn | 1071-7544 1521-0464 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Drug Delivery |
| spelling | doaj-art-aa588ad3086f433aa65b3c4b078f3dc72025-02-01T13:35:49ZengTaylor & Francis GroupDrug Delivery1071-75441521-04642025-12-0132110.1080/10717544.2025.2459772Targeted nanoliposomes for precision rheumatoid arthritis therapy: a review on mechanisms and in vivo potentialRushikesh Girase0Nayan A. Gujarathi1Amey Sukhia2Sri Sai Nikitha Kota3Tulshidas S. Patil4Abhijeet A. Aher5Yogeeta O. Agrawal6Shreesh Ojha7Charu Sharma8Sameer N. Goyal9Shri Vile Parle Kelavani Mandal’s Institute of Pharmacy, Dhule, IndiaShri Vile Parle Kelavani Mandal’s Institute of Pharmacy, Dhule, IndiaDepartment of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, USADepartment of Molecular Pharmaceutics and Drug Delivery, The University of Texas at Austin, Austin, TX, USAShri Vile Parle Kelavani Mandal’s Institute of Pharmacy, Dhule, IndiaShri Vile Parle Kelavani Mandal’s Institute of Pharmacy, Dhule, IndiaShri Vile Parle Kelavani Mandal’s Institute of Pharmacy, Dhule, IndiaDepartment of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, United Arab EmiratesDepartment of Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, United Arab EmiratesShri Vile Parle Kelavani Mandal’s Institute of Pharmacy, Dhule, IndiaRheumatoid arthritis (RA) is an inflammatory immune-triggered disease that causes synovitis, cartilage degradation, and joint injury. In nanotechnology, conventional liposomes were extensively investigated for RA. However, they frequently undergo rapid clearance, reducing circulation time and therapeutic efficacy. Additionally, their stability in the bloodstream is often compromised, resulting in premature drug release. The current review explores the potential of targeted liposomal-based nanosystems in the treatment of RA. It highlights the pathophysiology of RA, explores selective targeting sites, and elucidates diverse mechanisms of novel liposomal types and their applications. Furthermore, the targeting strategies of pH-sensitive, flexible, surface-modified, PEGylated, acoustic, ROS-mediated, and biofunctionalized liposomes are addressed. Targeted nanoliposomes showed potential in precisely delivering drugs to CD44, SR-A, FR-β, FLS, and toll-like receptors through the high affinity of ligands. In vitro studies interpreted stable release profiles and improved stability. Ex vivo studies on skin demonstrated that ultradeformable and glycerol-conjugated liposomes enhanced drug penetrability. In vivo experiments for liposomal types in the arthritis rat model depicted remarkable efficacy in reducing joint swelling, pro-inflammatory cytokines, and synovial hyperplasia. In conclusion, these targeted liposomes represented a significant leap forward in drug delivery, offering effective therapeutic options for RA. In the future, integrating these advanced liposomes with artificial intelligence, immunotherapy, and precision medicine holds great promise.https://www.tandfonline.com/doi/10.1080/10717544.2025.2459772Rheumatoid arthritissurface modified liposomespH-sensitive liposomesultradeformable liposomesacoustic liposomesbiofunctionalized liposomes |
| spellingShingle | Rushikesh Girase Nayan A. Gujarathi Amey Sukhia Sri Sai Nikitha Kota Tulshidas S. Patil Abhijeet A. Aher Yogeeta O. Agrawal Shreesh Ojha Charu Sharma Sameer N. Goyal Targeted nanoliposomes for precision rheumatoid arthritis therapy: a review on mechanisms and in vivo potential Drug Delivery Rheumatoid arthritis surface modified liposomes pH-sensitive liposomes ultradeformable liposomes acoustic liposomes biofunctionalized liposomes |
| title | Targeted nanoliposomes for precision rheumatoid arthritis therapy: a review on mechanisms and in vivo potential |
| title_full | Targeted nanoliposomes for precision rheumatoid arthritis therapy: a review on mechanisms and in vivo potential |
| title_fullStr | Targeted nanoliposomes for precision rheumatoid arthritis therapy: a review on mechanisms and in vivo potential |
| title_full_unstemmed | Targeted nanoliposomes for precision rheumatoid arthritis therapy: a review on mechanisms and in vivo potential |
| title_short | Targeted nanoliposomes for precision rheumatoid arthritis therapy: a review on mechanisms and in vivo potential |
| title_sort | targeted nanoliposomes for precision rheumatoid arthritis therapy a review on mechanisms and in vivo potential |
| topic | Rheumatoid arthritis surface modified liposomes pH-sensitive liposomes ultradeformable liposomes acoustic liposomes biofunctionalized liposomes |
| url | https://www.tandfonline.com/doi/10.1080/10717544.2025.2459772 |
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