High Association between Human Circulating MicroRNA-497 and Acute Myocardial Infarction
Recent papers have reported the fundamental roles of miR-497 in infarction which acute myocardial infarction (AMI) belongs to. However, the expression levels of miR-497 in AMI patients were unclear, especially the circulating miR-497 that was detectable in the human plasma. In this study, we focused...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/931845 |
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| _version_ | 1832548485480579072 |
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| author | Zhenci Li Jing Lu Yi Luo Shaonan Li Minsheng Chen |
| author_facet | Zhenci Li Jing Lu Yi Luo Shaonan Li Minsheng Chen |
| author_sort | Zhenci Li |
| collection | DOAJ |
| description | Recent papers have reported the fundamental roles of miR-497 in infarction which acute myocardial infarction (AMI) belongs to. However, the expression levels of miR-497 in AMI patients were unclear, especially the circulating miR-497 that was detectable in the human plasma. In this study, we focused on the expression levels of circulating miR-497 in AMI and the roles of plasma miR-497 as a promising biomarker for AMI. The plasma miR-497 levels were detected from 27 AMI patients and 31 healthy volunteers by qRT-PCR. The cTnI concentrations of these samples were also analyzed by ELISA. Results showed circulating miR-497 levels were upregulated in AMI patients at 4 h, 8 h, 12 h, and 24 h, by contrast to those in control. Interestingly, time courses of circulating miR-497 levels displayed similar trends to that of cTnI concentrations in AMI patients; further study revealed the high correlation between circulating miR-497 and cTnI concentrations (r=0.573, P<0.001). At last, the receiver operating characteristic (ROC) curve was performed and declared that there was a faithworthy sensitivity and specificity to identify the AMI patients by using circulating miR-497. In conclusion, circulating miR-497 might be a promising biomarker for AMI identification and there was high association between human miR-497 and acute myocardial infarction. |
| format | Article |
| id | doaj-art-aa4f1418429543d68aace46a5b0fb190 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-aa4f1418429543d68aace46a5b0fb1902025-02-03T06:13:54ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/931845931845High Association between Human Circulating MicroRNA-497 and Acute Myocardial InfarctionZhenci Li0Jing Lu1Yi Luo2Shaonan Li3Minsheng Chen4Department of Cardiology, Guangzhou First Municipal People’s Hospital, Guangzhou Medical University, Panfu Road 1, Guangzhou, Guangdong 510180, ChinaDepartment of Cardiology, Guangzhou First Municipal People’s Hospital, Guangzhou Medical University, Panfu Road 1, Guangzhou, Guangdong 510180, ChinaDepartment of Cardiology, Guangzhou First Municipal People’s Hospital, Guangzhou Medical University, Panfu Road 1, Guangzhou, Guangdong 510180, ChinaDepartment of Cardiology, Guangzhou First Municipal People’s Hospital, Guangzhou Medical University, Panfu Road 1, Guangzhou, Guangdong 510180, ChinaSouthern Medical University, Guangzhou Avenue North 1838, Guangzhou, Guangdong 510515, ChinaRecent papers have reported the fundamental roles of miR-497 in infarction which acute myocardial infarction (AMI) belongs to. However, the expression levels of miR-497 in AMI patients were unclear, especially the circulating miR-497 that was detectable in the human plasma. In this study, we focused on the expression levels of circulating miR-497 in AMI and the roles of plasma miR-497 as a promising biomarker for AMI. The plasma miR-497 levels were detected from 27 AMI patients and 31 healthy volunteers by qRT-PCR. The cTnI concentrations of these samples were also analyzed by ELISA. Results showed circulating miR-497 levels were upregulated in AMI patients at 4 h, 8 h, 12 h, and 24 h, by contrast to those in control. Interestingly, time courses of circulating miR-497 levels displayed similar trends to that of cTnI concentrations in AMI patients; further study revealed the high correlation between circulating miR-497 and cTnI concentrations (r=0.573, P<0.001). At last, the receiver operating characteristic (ROC) curve was performed and declared that there was a faithworthy sensitivity and specificity to identify the AMI patients by using circulating miR-497. In conclusion, circulating miR-497 might be a promising biomarker for AMI identification and there was high association between human miR-497 and acute myocardial infarction.http://dx.doi.org/10.1155/2014/931845 |
| spellingShingle | Zhenci Li Jing Lu Yi Luo Shaonan Li Minsheng Chen High Association between Human Circulating MicroRNA-497 and Acute Myocardial Infarction The Scientific World Journal |
| title | High Association between Human Circulating MicroRNA-497 and Acute Myocardial Infarction |
| title_full | High Association between Human Circulating MicroRNA-497 and Acute Myocardial Infarction |
| title_fullStr | High Association between Human Circulating MicroRNA-497 and Acute Myocardial Infarction |
| title_full_unstemmed | High Association between Human Circulating MicroRNA-497 and Acute Myocardial Infarction |
| title_short | High Association between Human Circulating MicroRNA-497 and Acute Myocardial Infarction |
| title_sort | high association between human circulating microrna 497 and acute myocardial infarction |
| url | http://dx.doi.org/10.1155/2014/931845 |
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