Targeting Apoptosis Pathways in Cancer with Alantolactone and Isoalantolactone
Alantolactone and isoalantolactone, main bioactive compounds that are present in many medicinal plants such as Inula helenium, L. Inula japonica, Aucklandia lappa, Inula racemosa, and Radix inulae, have been found to have various pharmacological actions including anti-inflammatory, antimicrobial, an...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/248532 |
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| author | Azhar Rasul Muhammad Khan Muhammad Ali Jiang Li Xiaomeng Li |
| author_facet | Azhar Rasul Muhammad Khan Muhammad Ali Jiang Li Xiaomeng Li |
| author_sort | Azhar Rasul |
| collection | DOAJ |
| description | Alantolactone and isoalantolactone, main bioactive compounds that are present in many medicinal plants such as Inula helenium, L. Inula japonica, Aucklandia lappa, Inula racemosa, and Radix inulae, have been found to have various pharmacological actions including anti-inflammatory, antimicrobial, and anticancer properties, with no significant toxicity. Recently, the anticancer activity of alantolactone and isoalantolactone has been extensively investigated. Here, our aim is to review their natural sources and their anticancer activity with specific emphasis on mechanism of actions, by which these compounds act on apoptosis pathways. Based on the literature and also on our previous results, alantolactone and isoalantolactone induce apoptosis by targeting multiple cellular signaling pathways that are frequently deregulated in cancers and suggest that their simultaneous targeting by these compounds could result in efficacious and selective killing of cancer cells. This review suggests that alantolactone and isoalantolactone are potential promising anticancer candidates, but additional studies and clinical trials are required to determine their specific intracellular sites of actions and derivative targets in order to fully understand the mechanisms of therapeutic effects to further validate in cancer chemotherapy. |
| format | Article |
| id | doaj-art-aa38f782bc8148c9b9311ecb9efd23c8 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-aa38f782bc8148c9b9311ecb9efd23c82025-02-03T07:25:33ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/248532248532Targeting Apoptosis Pathways in Cancer with Alantolactone and IsoalantolactoneAzhar Rasul0Muhammad Khan1Muhammad Ali2Jiang Li3Xiaomeng Li4The Key Laboratory of Molecular Epigenetics of MOE, Institute of Genetics and Cytology, Northeast Normal University, Changchun 130024, ChinaDepartment of Zoology, University of the Punjab, Lahore 54590, PakistanInstitute of Molecular and Biotechnology, Bahauddin Zakariya University, Multan 60800, PakistanDental Hospital, Jilin University, Changchun 130041, ChinaThe Key Laboratory of Molecular Epigenetics of MOE, Institute of Genetics and Cytology, Northeast Normal University, Changchun 130024, ChinaAlantolactone and isoalantolactone, main bioactive compounds that are present in many medicinal plants such as Inula helenium, L. Inula japonica, Aucklandia lappa, Inula racemosa, and Radix inulae, have been found to have various pharmacological actions including anti-inflammatory, antimicrobial, and anticancer properties, with no significant toxicity. Recently, the anticancer activity of alantolactone and isoalantolactone has been extensively investigated. Here, our aim is to review their natural sources and their anticancer activity with specific emphasis on mechanism of actions, by which these compounds act on apoptosis pathways. Based on the literature and also on our previous results, alantolactone and isoalantolactone induce apoptosis by targeting multiple cellular signaling pathways that are frequently deregulated in cancers and suggest that their simultaneous targeting by these compounds could result in efficacious and selective killing of cancer cells. This review suggests that alantolactone and isoalantolactone are potential promising anticancer candidates, but additional studies and clinical trials are required to determine their specific intracellular sites of actions and derivative targets in order to fully understand the mechanisms of therapeutic effects to further validate in cancer chemotherapy.http://dx.doi.org/10.1155/2013/248532 |
| spellingShingle | Azhar Rasul Muhammad Khan Muhammad Ali Jiang Li Xiaomeng Li Targeting Apoptosis Pathways in Cancer with Alantolactone and Isoalantolactone The Scientific World Journal |
| title | Targeting Apoptosis Pathways in Cancer with Alantolactone and Isoalantolactone |
| title_full | Targeting Apoptosis Pathways in Cancer with Alantolactone and Isoalantolactone |
| title_fullStr | Targeting Apoptosis Pathways in Cancer with Alantolactone and Isoalantolactone |
| title_full_unstemmed | Targeting Apoptosis Pathways in Cancer with Alantolactone and Isoalantolactone |
| title_short | Targeting Apoptosis Pathways in Cancer with Alantolactone and Isoalantolactone |
| title_sort | targeting apoptosis pathways in cancer with alantolactone and isoalantolactone |
| url | http://dx.doi.org/10.1155/2013/248532 |
| work_keys_str_mv | AT azharrasul targetingapoptosispathwaysincancerwithalantolactoneandisoalantolactone AT muhammadkhan targetingapoptosispathwaysincancerwithalantolactoneandisoalantolactone AT muhammadali targetingapoptosispathwaysincancerwithalantolactoneandisoalantolactone AT jiangli targetingapoptosispathwaysincancerwithalantolactoneandisoalantolactone AT xiaomengli targetingapoptosispathwaysincancerwithalantolactoneandisoalantolactone |