Predictors of Insulin Resistance in Children versus Adolescents with Obesity
Introduction. Obesity is a risk factor to develop metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM). Insulin resistance (IR) plays a major part in both. With increasing incidence of childhood obesity, this retrospective study aimed to identify predictors of IR in children/adolescents wit...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2017/3793868 |
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| author | Yvette E. Lentferink Marieke A. J. Elst Catherijne A. J. Knibbe Marja M. J. van der Vorst |
| author_facet | Yvette E. Lentferink Marieke A. J. Elst Catherijne A. J. Knibbe Marja M. J. van der Vorst |
| author_sort | Yvette E. Lentferink |
| collection | DOAJ |
| description | Introduction. Obesity is a risk factor to develop metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM). Insulin resistance (IR) plays a major part in both. With increasing incidence of childhood obesity, this retrospective study aimed to identify predictors of IR in children/adolescents with obesity to optimize screening for IR. Method. Patients aged ≥ 2–≤ 18 years with obesity (BMI-SDS > 2.3) were included. IR was defined as HOMA-IR ≥ 3.4, and MetS if ≥3 of the following criteria were present: waist circumference and blood pressure ≥ 95th age percentile, triglycerides ≥ 1.7 mmol/l, HDL < 1.03 mmol/l, and fasting plasma glucose ≥ 5.6 mmol/l. Results. In total, 777 patients were included. Of the 306 children, 51, 38, and 0 were diagnosed with IR, MetS, and T2DM, respectively. Of the 471 adolescents, 223, 95, and 0 were diagnosed with IR, MetS, and T2DM, respectively. In the multivariable regression model, BMI-SDS, preterm birth, and Tanner stage were associated with IR in children (6.3 (95% CI 1.3–31.1), 5.4 (95% CI 1.4–20.5), 2.2 (95% CI 1.0–4.8)), and BMI-SDS and waist circumference in adolescents (4.0 (95% CI 1.7–9.2), 3.7 (95% CI 1.5–9.4)). Conclusion. Different IR predictors were observed in children/adolescents with obesity. These predictors can be used to optimize screening for IR in pediatric populations. |
| format | Article |
| id | doaj-art-aa31a9b0c31d433c956f8d98293e0617 |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-aa31a9b0c31d433c956f8d98293e06172025-02-03T01:23:58ZengWileyJournal of Obesity2090-07082090-07162017-01-01201710.1155/2017/37938683793868Predictors of Insulin Resistance in Children versus Adolescents with ObesityYvette E. Lentferink0Marieke A. J. Elst1Catherijne A. J. Knibbe2Marja M. J. van der Vorst3Department of Pediatrics, St. Antonius Hospital, Nieuwegein/Utrecht, Postbus 2500, 3430 EM Nieuwegein, NetherlandsDepartment of Pediatrics, St. Antonius Hospital, Nieuwegein/Utrecht, Postbus 2500, 3430 EM Nieuwegein, NetherlandsDepartment of Clinical Pharmacy, St. Antonius Hospital, Nieuwegein/Utrecht, Postbus 2500, 3430 EM Nieuwegein, NetherlandsDepartment of Pediatrics, St. Antonius Hospital, Nieuwegein/Utrecht, Postbus 2500, 3430 EM Nieuwegein, NetherlandsIntroduction. Obesity is a risk factor to develop metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM). Insulin resistance (IR) plays a major part in both. With increasing incidence of childhood obesity, this retrospective study aimed to identify predictors of IR in children/adolescents with obesity to optimize screening for IR. Method. Patients aged ≥ 2–≤ 18 years with obesity (BMI-SDS > 2.3) were included. IR was defined as HOMA-IR ≥ 3.4, and MetS if ≥3 of the following criteria were present: waist circumference and blood pressure ≥ 95th age percentile, triglycerides ≥ 1.7 mmol/l, HDL < 1.03 mmol/l, and fasting plasma glucose ≥ 5.6 mmol/l. Results. In total, 777 patients were included. Of the 306 children, 51, 38, and 0 were diagnosed with IR, MetS, and T2DM, respectively. Of the 471 adolescents, 223, 95, and 0 were diagnosed with IR, MetS, and T2DM, respectively. In the multivariable regression model, BMI-SDS, preterm birth, and Tanner stage were associated with IR in children (6.3 (95% CI 1.3–31.1), 5.4 (95% CI 1.4–20.5), 2.2 (95% CI 1.0–4.8)), and BMI-SDS and waist circumference in adolescents (4.0 (95% CI 1.7–9.2), 3.7 (95% CI 1.5–9.4)). Conclusion. Different IR predictors were observed in children/adolescents with obesity. These predictors can be used to optimize screening for IR in pediatric populations.http://dx.doi.org/10.1155/2017/3793868 |
| spellingShingle | Yvette E. Lentferink Marieke A. J. Elst Catherijne A. J. Knibbe Marja M. J. van der Vorst Predictors of Insulin Resistance in Children versus Adolescents with Obesity Journal of Obesity |
| title | Predictors of Insulin Resistance in Children versus Adolescents with Obesity |
| title_full | Predictors of Insulin Resistance in Children versus Adolescents with Obesity |
| title_fullStr | Predictors of Insulin Resistance in Children versus Adolescents with Obesity |
| title_full_unstemmed | Predictors of Insulin Resistance in Children versus Adolescents with Obesity |
| title_short | Predictors of Insulin Resistance in Children versus Adolescents with Obesity |
| title_sort | predictors of insulin resistance in children versus adolescents with obesity |
| url | http://dx.doi.org/10.1155/2017/3793868 |
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