Severe Symptomatic Hypocalcemia from HIV Related Hypoparathyroidism
We report the case of a 54-year-old Caucasian female who presented with a two-year history of persistent hypocalcemia requiring multiple hospitalizations. Her medical history was significant for HIV diagnosed four years ago. She denied any history of prior neck surgery or radiation. Her vital signs...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2018/8270936 |
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| author | Sartaj Sandhu Akshata Desai Manav Batra Robin Girdhar Kaushik Chatterjee E. Helen Kemp Antoine Makdissi Ajay Chaudhuri |
| author_facet | Sartaj Sandhu Akshata Desai Manav Batra Robin Girdhar Kaushik Chatterjee E. Helen Kemp Antoine Makdissi Ajay Chaudhuri |
| author_sort | Sartaj Sandhu |
| collection | DOAJ |
| description | We report the case of a 54-year-old Caucasian female who presented with a two-year history of persistent hypocalcemia requiring multiple hospitalizations. Her medical history was significant for HIV diagnosed four years ago. She denied any history of prior neck surgery or radiation. Her vital signs were stable with an unremarkable physical exam. Pertinent medications included calcium carbonate, vitamin D3, calcitriol, efavirenz, emtricitabine, tenofovir disoproxil, hydrochlorothiazide, and inhaled budesonide/formoterol. Laboratory testing showed total calcium of 5.7 mg/dL (normal range: 8.4-10.2 mg/dL), ionized calcium of 2.7 mg/dL (normal range: 4.5-5.5 mg/dL), serum phosphate of 6.3 mg/dL (normal range: 2.7-4.5 mg/dL), and intact PTH of 7.6 pg/mL (normal range: 15-65 pg/mL). She was diagnosed with primary hypoparathyroidism. Anti-calcium-sensing receptor antibodies and NALP5 antibodies were tested and found to be negative. During subsequent clinic visits, doses of calcium supplements and calcitriol were titrated. Last corrected serum calcium level was 9.18 mg/dL. She was subsequently lost to follow-up. This case gives insight into severe symptomatic hypocalcemia from primary hypoparathyroidism attributed to HIV infection. We suggest that calcium levels should be closely monitored in patients with HIV infection. |
| format | Article |
| id | doaj-art-aa2edc03b34c4c9b9fcf6cb82a68779a |
| institution | Kabale University |
| issn | 2090-6501 2090-651X |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-aa2edc03b34c4c9b9fcf6cb82a68779a2025-02-03T05:54:06ZengWileyCase Reports in Endocrinology2090-65012090-651X2018-01-01201810.1155/2018/82709368270936Severe Symptomatic Hypocalcemia from HIV Related HypoparathyroidismSartaj Sandhu0Akshata Desai1Manav Batra2Robin Girdhar3Kaushik Chatterjee4E. Helen Kemp5Antoine Makdissi6Ajay Chaudhuri7Advocare DelGiorno Endocrinology, Sewell, New Jersey, USADepartment of Endocrinology, Diabetes and Metabolism, State University of New York, Buffalo, New York, USADepartment of Endocrinology, Diabetes and Metabolism, State University of New York, Buffalo, New York, USADepartment of Endocrinology, Diabetes and Metabolism, State University of New York, Buffalo, New York, USADepartment of Endocrinology, Diabetes and Metabolism, State University of New York, Buffalo, New York, USADepartment of Oncology and Metabolism, University of Sheffield, Sheffield, UKDepartment of Endocrinology, Diabetes and Metabolism, State University of New York, Buffalo, New York, USADepartment of Endocrinology, Diabetes and Metabolism, State University of New York, Buffalo, New York, USAWe report the case of a 54-year-old Caucasian female who presented with a two-year history of persistent hypocalcemia requiring multiple hospitalizations. Her medical history was significant for HIV diagnosed four years ago. She denied any history of prior neck surgery or radiation. Her vital signs were stable with an unremarkable physical exam. Pertinent medications included calcium carbonate, vitamin D3, calcitriol, efavirenz, emtricitabine, tenofovir disoproxil, hydrochlorothiazide, and inhaled budesonide/formoterol. Laboratory testing showed total calcium of 5.7 mg/dL (normal range: 8.4-10.2 mg/dL), ionized calcium of 2.7 mg/dL (normal range: 4.5-5.5 mg/dL), serum phosphate of 6.3 mg/dL (normal range: 2.7-4.5 mg/dL), and intact PTH of 7.6 pg/mL (normal range: 15-65 pg/mL). She was diagnosed with primary hypoparathyroidism. Anti-calcium-sensing receptor antibodies and NALP5 antibodies were tested and found to be negative. During subsequent clinic visits, doses of calcium supplements and calcitriol were titrated. Last corrected serum calcium level was 9.18 mg/dL. She was subsequently lost to follow-up. This case gives insight into severe symptomatic hypocalcemia from primary hypoparathyroidism attributed to HIV infection. We suggest that calcium levels should be closely monitored in patients with HIV infection.http://dx.doi.org/10.1155/2018/8270936 |
| spellingShingle | Sartaj Sandhu Akshata Desai Manav Batra Robin Girdhar Kaushik Chatterjee E. Helen Kemp Antoine Makdissi Ajay Chaudhuri Severe Symptomatic Hypocalcemia from HIV Related Hypoparathyroidism Case Reports in Endocrinology |
| title | Severe Symptomatic Hypocalcemia from HIV Related Hypoparathyroidism |
| title_full | Severe Symptomatic Hypocalcemia from HIV Related Hypoparathyroidism |
| title_fullStr | Severe Symptomatic Hypocalcemia from HIV Related Hypoparathyroidism |
| title_full_unstemmed | Severe Symptomatic Hypocalcemia from HIV Related Hypoparathyroidism |
| title_short | Severe Symptomatic Hypocalcemia from HIV Related Hypoparathyroidism |
| title_sort | severe symptomatic hypocalcemia from hiv related hypoparathyroidism |
| url | http://dx.doi.org/10.1155/2018/8270936 |
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