Spatiotemporal Regulators for Insulin-Stimulated GLUT4 Vesicle Exocytosis
Insulin increases glucose uptake and storage in muscle and adipose cells, which is accomplished through the mobilization of intracellular GLUT4 storage vesicles (GSVs) to the cell surface upon stimulation. Importantly, the dysfunction of insulin-regulated GLUT4 trafficking is strongly linked with pe...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2017/1683678 |
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| _version_ | 1832563934022860800 |
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| author | Xiaoxu Zhou Ping Shentu Yingke Xu |
| author_facet | Xiaoxu Zhou Ping Shentu Yingke Xu |
| author_sort | Xiaoxu Zhou |
| collection | DOAJ |
| description | Insulin increases glucose uptake and storage in muscle and adipose cells, which is accomplished through the mobilization of intracellular GLUT4 storage vesicles (GSVs) to the cell surface upon stimulation. Importantly, the dysfunction of insulin-regulated GLUT4 trafficking is strongly linked with peripheral insulin resistance and type 2 diabetes in human. The insulin signaling pathway, key signaling molecules involved, and precise trafficking itinerary of GSVs are largely identified. Understanding the interaction between insulin signaling molecules and key regulatory proteins that are involved in spatiotemporal regulation of GLUT4 vesicle exocytosis is of great importance to explain the pathogenesis of diabetes and may provide new potential therapeutic targets. |
| format | Article |
| id | doaj-art-aa14c2a5957d493388054668a12c7df3 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-aa14c2a5957d493388054668a12c7df32025-02-03T01:12:10ZengWileyJournal of Diabetes Research2314-67452314-67532017-01-01201710.1155/2017/16836781683678Spatiotemporal Regulators for Insulin-Stimulated GLUT4 Vesicle ExocytosisXiaoxu Zhou0Ping Shentu1Yingke Xu2Department of Biomedical Engineering, Key Laboratory for Biomedical Engineering of Ministry of Education, Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou 310027, ChinaDepartment of Biomedical Engineering, Key Laboratory for Biomedical Engineering of Ministry of Education, Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou 310027, ChinaDepartment of Biomedical Engineering, Key Laboratory for Biomedical Engineering of Ministry of Education, Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou 310027, ChinaInsulin increases glucose uptake and storage in muscle and adipose cells, which is accomplished through the mobilization of intracellular GLUT4 storage vesicles (GSVs) to the cell surface upon stimulation. Importantly, the dysfunction of insulin-regulated GLUT4 trafficking is strongly linked with peripheral insulin resistance and type 2 diabetes in human. The insulin signaling pathway, key signaling molecules involved, and precise trafficking itinerary of GSVs are largely identified. Understanding the interaction between insulin signaling molecules and key regulatory proteins that are involved in spatiotemporal regulation of GLUT4 vesicle exocytosis is of great importance to explain the pathogenesis of diabetes and may provide new potential therapeutic targets.http://dx.doi.org/10.1155/2017/1683678 |
| spellingShingle | Xiaoxu Zhou Ping Shentu Yingke Xu Spatiotemporal Regulators for Insulin-Stimulated GLUT4 Vesicle Exocytosis Journal of Diabetes Research |
| title | Spatiotemporal Regulators for Insulin-Stimulated GLUT4 Vesicle Exocytosis |
| title_full | Spatiotemporal Regulators for Insulin-Stimulated GLUT4 Vesicle Exocytosis |
| title_fullStr | Spatiotemporal Regulators for Insulin-Stimulated GLUT4 Vesicle Exocytosis |
| title_full_unstemmed | Spatiotemporal Regulators for Insulin-Stimulated GLUT4 Vesicle Exocytosis |
| title_short | Spatiotemporal Regulators for Insulin-Stimulated GLUT4 Vesicle Exocytosis |
| title_sort | spatiotemporal regulators for insulin stimulated glut4 vesicle exocytosis |
| url | http://dx.doi.org/10.1155/2017/1683678 |
| work_keys_str_mv | AT xiaoxuzhou spatiotemporalregulatorsforinsulinstimulatedglut4vesicleexocytosis AT pingshentu spatiotemporalregulatorsforinsulinstimulatedglut4vesicleexocytosis AT yingkexu spatiotemporalregulatorsforinsulinstimulatedglut4vesicleexocytosis |