eNOS S-nitrosylates β-actin on Cys374 and regulates PKC-θ at the immune synapse by impairing actin binding to profilin-1.

eNOS S-nitrosylates β-actin on Cys374 and regulates PKC-θ at the immune synapse by impairing actin binding to profilin-1.

The actin cytoskeleton coordinates the organization of signaling microclusters at the immune synapse (IS); however, the mechanisms involved remain poorly understood. We show here that nitric oxide (NO) generated by endothelial nitric oxide synthase (eNOS) controls the coalescence of protein kinase C...

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Main Authors: Almudena García-Ortiz, Noa B Martín-Cofreces, Sales Ibiza, Ángel Ortega, Alicia Izquierdo-Álvarez, Antonio Trullo, Víctor M Victor, Enrique Calvo, Begoña Sot, Antonio Martínez-Ruiz, Jesús Vázquez, Francisco Sánchez-Madrid, Juan M Serrador
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-04-01
Series:PLoS Biology
Online Access:https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.2000653&type=printable
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