Sensory neuron–specific block of multifaceted sodium channels mitigates neuropathic pain behaviors of osteoarthritis
Objective:. Multiple voltage-gated sodium channels (NaVs) in the peripheral sensory neurons (PSNs) regulate action potentials and their dysfunction contributes to the pain pathogenesis of osteoarthritis (OA). A combined block of multiple NaV subtypes selectively in the PSNs may, therefore, represent...
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| Main Authors: | Seung Min Shin, Brandon Itson-Zoske, Hao Xu, Hongfei Xiang, Fan Fan, Quinn H. Hogan, Hongwei Yu |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer
2025-08-01
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| Series: | PAIN Reports |
| Online Access: | http://journals.lww.com/painrpts/fulltext/10.1097/PR9.0000000000001288 |
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