Interleukin-22 Might Act as a Double-Edged Sword in Type 2 Diabetes and Coronary Artery Disease
Type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD) are both characterized by chronic low-grade inflammation. The role of Th17 and its related cytokines in T2DM and CAD is unclear. Here we investigated the serum levels of five Th17-related cytokines (IL-17, IL-22, MIP-3α, IL-9, and IL-...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/8254797 |
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| author | Fangchen Gong Jin Wu Ping Zhou Mengyao Zhang Jingning Liu Ying Liu Xiang Lu Zhengxia Liu |
| author_facet | Fangchen Gong Jin Wu Ping Zhou Mengyao Zhang Jingning Liu Ying Liu Xiang Lu Zhengxia Liu |
| author_sort | Fangchen Gong |
| collection | DOAJ |
| description | Type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD) are both characterized by chronic low-grade inflammation. The role of Th17 and its related cytokines in T2DM and CAD is unclear. Here we investigated the serum levels of five Th17-related cytokines (IL-17, IL-22, MIP-3α, IL-9, and IL-27) in T2DM, CAD, and T2DM-CAD comorbidity patients. IL-22 was found to be elevated in all three conditions. Elevated serum IL-22 was independently associated with the incidence of T2DM and CAD. Conversely, IL-22 was found to protect endothelial cells from glucose- and lysophosphatidylcholine- (LPC-) induced injury, and IL-22R1 expression on endothelial cells was increased upon treatment with high glucose and LPC. Blocking of IL-22R1 with IL-22R1 antibody diminished the protective role of IL-22. Our results suggest that IL-22 functions as a double-edged sword in T2DM and CAD and that IL-22 may be used in the treatment of chronic inflammatory diseases such as T2DM and CAD. |
| format | Article |
| id | doaj-art-a9fadf090a93498686742105d8033a87 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-a9fadf090a93498686742105d8033a872025-02-03T06:00:05ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/82547978254797Interleukin-22 Might Act as a Double-Edged Sword in Type 2 Diabetes and Coronary Artery DiseaseFangchen Gong0Jin Wu1Ping Zhou2Mengyao Zhang3Jingning Liu4Ying Liu5Xiang Lu6Zhengxia Liu7Department of Geriatrics, The Second Affiliated Hospital, Nanjing Medical University, Jiangsu 210029, ChinaDepartment of Neurology, The Second Affiliated Hospital, Nanjing Medical University, Jiangsu 210029, ChinaDepartment of Geriatrics, The Second Affiliated Hospital, Nanjing Medical University, Jiangsu 210029, ChinaDepartment of Geriatrics, The Second Affiliated Hospital, Nanjing Medical University, Jiangsu 210029, ChinaDepartment of Geriatrics, The Second Affiliated Hospital, Nanjing Medical University, Jiangsu 210029, ChinaDepartment of Geriatrics, The Second Affiliated Hospital, Nanjing Medical University, Jiangsu 210029, ChinaDepartment of Geriatrics, The Second Affiliated Hospital, Nanjing Medical University, Jiangsu 210029, ChinaDepartment of Geriatrics, The Second Affiliated Hospital, Nanjing Medical University, Jiangsu 210029, ChinaType 2 diabetes mellitus (T2DM) and coronary artery disease (CAD) are both characterized by chronic low-grade inflammation. The role of Th17 and its related cytokines in T2DM and CAD is unclear. Here we investigated the serum levels of five Th17-related cytokines (IL-17, IL-22, MIP-3α, IL-9, and IL-27) in T2DM, CAD, and T2DM-CAD comorbidity patients. IL-22 was found to be elevated in all three conditions. Elevated serum IL-22 was independently associated with the incidence of T2DM and CAD. Conversely, IL-22 was found to protect endothelial cells from glucose- and lysophosphatidylcholine- (LPC-) induced injury, and IL-22R1 expression on endothelial cells was increased upon treatment with high glucose and LPC. Blocking of IL-22R1 with IL-22R1 antibody diminished the protective role of IL-22. Our results suggest that IL-22 functions as a double-edged sword in T2DM and CAD and that IL-22 may be used in the treatment of chronic inflammatory diseases such as T2DM and CAD.http://dx.doi.org/10.1155/2016/8254797 |
| spellingShingle | Fangchen Gong Jin Wu Ping Zhou Mengyao Zhang Jingning Liu Ying Liu Xiang Lu Zhengxia Liu Interleukin-22 Might Act as a Double-Edged Sword in Type 2 Diabetes and Coronary Artery Disease Mediators of Inflammation |
| title | Interleukin-22 Might Act as a Double-Edged Sword in Type 2 Diabetes and Coronary Artery Disease |
| title_full | Interleukin-22 Might Act as a Double-Edged Sword in Type 2 Diabetes and Coronary Artery Disease |
| title_fullStr | Interleukin-22 Might Act as a Double-Edged Sword in Type 2 Diabetes and Coronary Artery Disease |
| title_full_unstemmed | Interleukin-22 Might Act as a Double-Edged Sword in Type 2 Diabetes and Coronary Artery Disease |
| title_short | Interleukin-22 Might Act as a Double-Edged Sword in Type 2 Diabetes and Coronary Artery Disease |
| title_sort | interleukin 22 might act as a double edged sword in type 2 diabetes and coronary artery disease |
| url | http://dx.doi.org/10.1155/2016/8254797 |
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