Nonhomologous DNA End Joining in Cell-Free Extracts
Among various DNA damages, double-strand breaks (DSBs) are considered as most deleterious, as they may lead to chromosomal rearrangements and cancer when unrepaired. Nonhomologous DNA end joining (NHEJ) is one of the major DSB repair pathways in higher organisms. A large number of studies on NHEJ a...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Journal of Nucleic Acids |
| Online Access: | http://dx.doi.org/10.4061/2010/389129 |
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| _version_ | 1832567539051266048 |
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| author | Sheetal Sharma Sathees C. Raghavan |
| author_facet | Sheetal Sharma Sathees C. Raghavan |
| author_sort | Sheetal Sharma |
| collection | DOAJ |
| description | Among various DNA damages, double-strand breaks (DSBs) are considered as most deleterious, as they may lead to chromosomal rearrangements and cancer when unrepaired. Nonhomologous DNA end joining (NHEJ) is one of the major DSB repair pathways in higher organisms. A large number of studies on NHEJ are based on in vitro systems using cell-free extracts. In this paper, we summarize the studies on NHEJ performed by various groups in different cell-free repair systems. |
| format | Article |
| id | doaj-art-a9f6ebaa6c6944f0b38bb866379dc6cb |
| institution | Kabale University |
| issn | 2090-021X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nucleic Acids |
| spelling | doaj-art-a9f6ebaa6c6944f0b38bb866379dc6cb2025-02-03T01:01:19ZengWileyJournal of Nucleic Acids2090-021X2010-01-01201010.4061/2010/389129389129Nonhomologous DNA End Joining in Cell-Free ExtractsSheetal Sharma0Sathees C. Raghavan1Department of Biochemistry, Indian Institute of Science, Bangalore 560 012, IndiaDepartment of Biochemistry, Indian Institute of Science, Bangalore 560 012, IndiaAmong various DNA damages, double-strand breaks (DSBs) are considered as most deleterious, as they may lead to chromosomal rearrangements and cancer when unrepaired. Nonhomologous DNA end joining (NHEJ) is one of the major DSB repair pathways in higher organisms. A large number of studies on NHEJ are based on in vitro systems using cell-free extracts. In this paper, we summarize the studies on NHEJ performed by various groups in different cell-free repair systems.http://dx.doi.org/10.4061/2010/389129 |
| spellingShingle | Sheetal Sharma Sathees C. Raghavan Nonhomologous DNA End Joining in Cell-Free Extracts Journal of Nucleic Acids |
| title | Nonhomologous DNA End Joining in Cell-Free Extracts |
| title_full | Nonhomologous DNA End Joining in Cell-Free Extracts |
| title_fullStr | Nonhomologous DNA End Joining in Cell-Free Extracts |
| title_full_unstemmed | Nonhomologous DNA End Joining in Cell-Free Extracts |
| title_short | Nonhomologous DNA End Joining in Cell-Free Extracts |
| title_sort | nonhomologous dna end joining in cell free extracts |
| url | http://dx.doi.org/10.4061/2010/389129 |
| work_keys_str_mv | AT sheetalsharma nonhomologousdnaendjoiningincellfreeextracts AT satheescraghavan nonhomologousdnaendjoiningincellfreeextracts |