Microbiota composition-based donor selection affects FMT efficacy in a murine colitis model

Microbiota composition-based donor selection affects FMT efficacy in a murine colitis model

BackgroundGrowing evidence links gut microbial dysbiosis to inflammatory bowel disease (IBD) pathogenesis, establishing fecal microbiota transplantation (FMT) as a microbiota-targeted therapy; however, variable outcomes in randomized trials highlight the need to identify compositional features of do...

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Main Authors: Zhongming Dai, Wen Cheng, Huan Peng, Xiaokui Qiu, Jiawen Sun, Xiaoqiang Liu, Xianjiu Sun, Jinwei Cai, Jincui Wang, Guolong Li, Yongling Lv, Shaobo Chen, Zhongying Zhong
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
gut microbiota
donor screening
FMT
IBD
16S rRNA
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1635244/full
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