Chordoma Spontaneous Regression After COVID-19
Chordomas are a low-to-intermediate-grade slow-growing subtype of sarcoma, but show propensity to grow and invade locally with recurrence and metastasis in 10–40% of cases. We describe the first case of spontaneous regression of a solid tumor (histologically and immunohistochemically proven chordoma...
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MDPI AG
2024-12-01
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| author | Luis Fernando Moura da Silva Junior Gyl Eanes Barros Silva Marcos Adriano Garcia Campos Antonio Augusto Lima Teixeira Júnior Ramon Moura Santos Orlando José dos Santos Natalino Salgado Filho |
| author_facet | Luis Fernando Moura da Silva Junior Gyl Eanes Barros Silva Marcos Adriano Garcia Campos Antonio Augusto Lima Teixeira Júnior Ramon Moura Santos Orlando José dos Santos Natalino Salgado Filho |
| author_sort | Luis Fernando Moura da Silva Junior |
| collection | DOAJ |
| description | Chordomas are a low-to-intermediate-grade slow-growing subtype of sarcoma, but show propensity to grow and invade locally with recurrence and metastasis in 10–40% of cases. We describe the first case of spontaneous regression of a solid tumor (histologically and immunohistochemically proven chordoma) after COVID-19. A female patient with clival chordoma underwent occipitocervical fixation prior to tumor resection. In the early post-operative stage following the arthrodesis procedure, she was diagnosed with COVID-19. Six months after COVID-19, she finally came back for endoscopic endonasal resection of the tumor and pre-operative MRI surprisingly showed 98.9% regression of the tumor volume. Tumor resection was performed, and both histopathological and immunohistochemistry confirmed diagnosis of chordoma with positive brachyury levels. She showed improvement of right hemiparesis and left-sided tongue palsy. The tumor was comprised of tumor-infiltrating inflammatory cells. CD3 and CD68 were positive, suggesting the presence of T-lymphocytes and macrophages. CD20 and CD56 were negative, suggesting the absence of B-lymphocytes and NK-cells. The authors believe that the onset of COVID-19 exacerbated the patient’s immune response and improved anti-tumor immunity. It was concluded that T-cells, which are involved in the COVID-19 immune response and were found infiltrating the tumor, acted as a critical pathway to this event. Further studies are encouraged in order to gain a better understanding of the SARS-CoV-2–chordoma interaction. |
| format | Article |
| id | doaj-art-a9f37918da04456896f388c1975de05f |
| institution | Kabale University |
| issn | 1999-4915 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj-art-a9f37918da04456896f388c1975de05f2025-01-24T13:52:14ZengMDPI AGViruses1999-49152024-12-011711010.3390/v17010010Chordoma Spontaneous Regression After COVID-19Luis Fernando Moura da Silva Junior0Gyl Eanes Barros Silva1Marcos Adriano Garcia Campos2Antonio Augusto Lima Teixeira Júnior3Ramon Moura Santos4Orlando José dos Santos5Natalino Salgado Filho6University Hospital of UFMA, Federal University of Maranhao, São Luís 65080-805, Maranhão, BrazilUniversity Hospital of UFMA, Federal University of Maranhao, São Luís 65080-805, Maranhão, BrazilDuke Global Health Institute, Duke University, Durham, NC 27710, USAPostgraduate Program in Genetics, Faculty of Medicine of Ribeirao Preto, University of São Paulo, Ribeirão Preto 14049-900, São Paulo, BrazilDr. Carlos Macieira Hospital, São Luís 65075-441, Maranhão, BrazilUniversity Hospital of UFMA, Federal University of Maranhao, São Luís 65080-805, Maranhão, BrazilUniversity Hospital of UFMA, Federal University of Maranhao, São Luís 65080-805, Maranhão, BrazilChordomas are a low-to-intermediate-grade slow-growing subtype of sarcoma, but show propensity to grow and invade locally with recurrence and metastasis in 10–40% of cases. We describe the first case of spontaneous regression of a solid tumor (histologically and immunohistochemically proven chordoma) after COVID-19. A female patient with clival chordoma underwent occipitocervical fixation prior to tumor resection. In the early post-operative stage following the arthrodesis procedure, she was diagnosed with COVID-19. Six months after COVID-19, she finally came back for endoscopic endonasal resection of the tumor and pre-operative MRI surprisingly showed 98.9% regression of the tumor volume. Tumor resection was performed, and both histopathological and immunohistochemistry confirmed diagnosis of chordoma with positive brachyury levels. She showed improvement of right hemiparesis and left-sided tongue palsy. The tumor was comprised of tumor-infiltrating inflammatory cells. CD3 and CD68 were positive, suggesting the presence of T-lymphocytes and macrophages. CD20 and CD56 were negative, suggesting the absence of B-lymphocytes and NK-cells. The authors believe that the onset of COVID-19 exacerbated the patient’s immune response and improved anti-tumor immunity. It was concluded that T-cells, which are involved in the COVID-19 immune response and were found infiltrating the tumor, acted as a critical pathway to this event. Further studies are encouraged in order to gain a better understanding of the SARS-CoV-2–chordoma interaction.https://www.mdpi.com/1999-4915/17/1/10spontaneous neoplastic regressioncoronavirus infectionnotochordsarcoma |
| spellingShingle | Luis Fernando Moura da Silva Junior Gyl Eanes Barros Silva Marcos Adriano Garcia Campos Antonio Augusto Lima Teixeira Júnior Ramon Moura Santos Orlando José dos Santos Natalino Salgado Filho Chordoma Spontaneous Regression After COVID-19 Viruses spontaneous neoplastic regression coronavirus infection notochord sarcoma |
| title | Chordoma Spontaneous Regression After COVID-19 |
| title_full | Chordoma Spontaneous Regression After COVID-19 |
| title_fullStr | Chordoma Spontaneous Regression After COVID-19 |
| title_full_unstemmed | Chordoma Spontaneous Regression After COVID-19 |
| title_short | Chordoma Spontaneous Regression After COVID-19 |
| title_sort | chordoma spontaneous regression after covid 19 |
| topic | spontaneous neoplastic regression coronavirus infection notochord sarcoma |
| url | https://www.mdpi.com/1999-4915/17/1/10 |
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