The Impact of Obstructive Sleep Apnoea and Nasal Continuous Positive Airway Pressure on Circulating Ischaemia-Modified Albumin Concentrations
The aim of the present study was to evaluate the impact of obstructive sleep apnoea syndrome (OSAS) and the effects of nasal continuous positive airway pressure (CPAP) on circulating ischaemia-modified albumin (IMA) concentrations. The study included 97 newly diagnosed OSAS patients and 30 nonapnoei...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/8907314 |
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| author | Firat Uygur Hakan Tanriverdi Murat Can Tacettin Ornek Fatma Erboy Bulent Altinsoy Figen Atalay Murat Damar Furuzan Kokturk Meltem Tor |
| author_facet | Firat Uygur Hakan Tanriverdi Murat Can Tacettin Ornek Fatma Erboy Bulent Altinsoy Figen Atalay Murat Damar Furuzan Kokturk Meltem Tor |
| author_sort | Firat Uygur |
| collection | DOAJ |
| description | The aim of the present study was to evaluate the impact of obstructive sleep apnoea syndrome (OSAS) and the effects of nasal continuous positive airway pressure (CPAP) on circulating ischaemia-modified albumin (IMA) concentrations. The study included 97 newly diagnosed OSAS patients and 30 nonapnoeic controls. Blood samples were obtained in the morning after polysomnography. After 3 months of CPAP treatment, 31 patients with moderate-severe OSAS were reassessed for serum IMA concentrations. Significantly higher serum IMA concentrations were measured in the OSAS group than in the control group [0.518±0.091 absorbance units (ABSU), 0.415±0.068 ABSU, P<0.001]. Serum IMA concentrations correlated significantly with the apnoea-hypopnoea index, mean SaO2, desaturation index, and C-reactive protein concentrations. Multiple logistic regression analyses showed that OSAS increased the serum IMA concentration independent of age, sex, body mass index, smoking habit, and cardiovascular disease. After 3 months of treatment with CPAP, OSAS patients had significantly lower serum IMA concentrations (0.555±0.062 ABSU to 0.431±0.063 ABSU, P<0.001). The results showed that OSAS is associated with elevated concentrations of IMA, which can be reversed by effective CPAP treatment. |
| format | Article |
| id | doaj-art-a9e6f6f6b7724aa9a82a3e0e531214a1 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-a9e6f6f6b7724aa9a82a3e0e531214a12025-02-03T05:48:39ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/89073148907314The Impact of Obstructive Sleep Apnoea and Nasal Continuous Positive Airway Pressure on Circulating Ischaemia-Modified Albumin ConcentrationsFirat Uygur0Hakan Tanriverdi1Murat Can2Tacettin Ornek3Fatma Erboy4Bulent Altinsoy5Figen Atalay6Murat Damar7Furuzan Kokturk8Meltem Tor9Faculty of Medicine, Department of Pulmonary Medicine, Bulent Ecevit University, 67600 Zonguldak, TurkeyFaculty of Medicine, Department of Pulmonary Medicine, Bulent Ecevit University, 67600 Zonguldak, TurkeyFaculty of Medicine, Department of Biochemistry Zonguldak, Bulent Ecevit University, 67600 Zonguldak, TurkeyFaculty of Medicine, Department of Pulmonary Medicine, Bulent Ecevit University, 67600 Zonguldak, TurkeyFaculty of Medicine, Department of Pulmonary Medicine, Bulent Ecevit University, 67600 Zonguldak, TurkeyFaculty of Medicine, Department of Pulmonary Medicine, Bulent Ecevit University, 67600 Zonguldak, TurkeyFaculty of Medicine, Department of Pulmonary Medicine, Bulent Ecevit University, 67600 Zonguldak, TurkeyFaculty of Medicine, Department of Otolaryngology, Bulent Ecevit University, 67600 Zonguldak, TurkeyFaculty of Medicine, Department of Biostatistics, Bulent Ecevit University, 67600 Zonguldak, TurkeyFaculty of Medicine, Department of Pulmonary Medicine, Bulent Ecevit University, 67600 Zonguldak, TurkeyThe aim of the present study was to evaluate the impact of obstructive sleep apnoea syndrome (OSAS) and the effects of nasal continuous positive airway pressure (CPAP) on circulating ischaemia-modified albumin (IMA) concentrations. The study included 97 newly diagnosed OSAS patients and 30 nonapnoeic controls. Blood samples were obtained in the morning after polysomnography. After 3 months of CPAP treatment, 31 patients with moderate-severe OSAS were reassessed for serum IMA concentrations. Significantly higher serum IMA concentrations were measured in the OSAS group than in the control group [0.518±0.091 absorbance units (ABSU), 0.415±0.068 ABSU, P<0.001]. Serum IMA concentrations correlated significantly with the apnoea-hypopnoea index, mean SaO2, desaturation index, and C-reactive protein concentrations. Multiple logistic regression analyses showed that OSAS increased the serum IMA concentration independent of age, sex, body mass index, smoking habit, and cardiovascular disease. After 3 months of treatment with CPAP, OSAS patients had significantly lower serum IMA concentrations (0.555±0.062 ABSU to 0.431±0.063 ABSU, P<0.001). The results showed that OSAS is associated with elevated concentrations of IMA, which can be reversed by effective CPAP treatment.http://dx.doi.org/10.1155/2016/8907314 |
| spellingShingle | Firat Uygur Hakan Tanriverdi Murat Can Tacettin Ornek Fatma Erboy Bulent Altinsoy Figen Atalay Murat Damar Furuzan Kokturk Meltem Tor The Impact of Obstructive Sleep Apnoea and Nasal Continuous Positive Airway Pressure on Circulating Ischaemia-Modified Albumin Concentrations Mediators of Inflammation |
| title | The Impact of Obstructive Sleep Apnoea and Nasal Continuous Positive Airway Pressure on Circulating Ischaemia-Modified Albumin Concentrations |
| title_full | The Impact of Obstructive Sleep Apnoea and Nasal Continuous Positive Airway Pressure on Circulating Ischaemia-Modified Albumin Concentrations |
| title_fullStr | The Impact of Obstructive Sleep Apnoea and Nasal Continuous Positive Airway Pressure on Circulating Ischaemia-Modified Albumin Concentrations |
| title_full_unstemmed | The Impact of Obstructive Sleep Apnoea and Nasal Continuous Positive Airway Pressure on Circulating Ischaemia-Modified Albumin Concentrations |
| title_short | The Impact of Obstructive Sleep Apnoea and Nasal Continuous Positive Airway Pressure on Circulating Ischaemia-Modified Albumin Concentrations |
| title_sort | impact of obstructive sleep apnoea and nasal continuous positive airway pressure on circulating ischaemia modified albumin concentrations |
| url | http://dx.doi.org/10.1155/2016/8907314 |
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