Ivabradine and Milrinone—Bridge to Recovery in New HFrEF With Low-Output Heart Failure
In patients with newly diagnosed heart failure with reduced ejection fraction (HFrEF) who are on a downward clinical trajectory, options are mostly limited to left ventricular assist device and transplantation. However, in those with factors favorable for reverse remodeling, every effort should be m...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Case Reports in Cardiology |
| Online Access: | http://dx.doi.org/10.1155/2024/5278240 |
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| _version_ | 1832544425345024000 |
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| author | Lekha Racharla Lucas Gitzel Max Joseph Desire Guthier Nael Hawwa |
| author_facet | Lekha Racharla Lucas Gitzel Max Joseph Desire Guthier Nael Hawwa |
| author_sort | Lekha Racharla |
| collection | DOAJ |
| description | In patients with newly diagnosed heart failure with reduced ejection fraction (HFrEF) who are on a downward clinical trajectory, options are mostly limited to left ventricular assist device and transplantation. However, in those with factors favorable for reverse remodeling, every effort should be made to promote native myocardial recovery. We present three patients with newly diagnosed severe HFrEF, NYHA Class 3–4 symptoms, and low cardiac output with and without organ malperfusion. Ivabradine and/or home milrinone were used during their tenuous hemodynamic period as a bridge to optimize guideline-directed medical therapy (GDMT), device therapy, and eventual reverse remodeling. Evidence of structural heart improvement continued far beyond 1 year. |
| format | Article |
| id | doaj-art-a9d91d9b9782489aabfb5f9dbf56bbb4 |
| institution | Kabale University |
| issn | 2090-6412 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Cardiology |
| spelling | doaj-art-a9d91d9b9782489aabfb5f9dbf56bbb42025-02-03T10:19:58ZengWileyCase Reports in Cardiology2090-64122024-01-01202410.1155/2024/5278240Ivabradine and Milrinone—Bridge to Recovery in New HFrEF With Low-Output Heart FailureLekha Racharla0Lucas Gitzel1Max Joseph2Desire Guthier3Nael Hawwa4Lehigh Valley Heart and Vascular InstituteDepartment of Internal MedicineMorsani College of MedicineDepartment of Cardiovascular MedicineLehigh Valley Heart and Vascular InstituteIn patients with newly diagnosed heart failure with reduced ejection fraction (HFrEF) who are on a downward clinical trajectory, options are mostly limited to left ventricular assist device and transplantation. However, in those with factors favorable for reverse remodeling, every effort should be made to promote native myocardial recovery. We present three patients with newly diagnosed severe HFrEF, NYHA Class 3–4 symptoms, and low cardiac output with and without organ malperfusion. Ivabradine and/or home milrinone were used during their tenuous hemodynamic period as a bridge to optimize guideline-directed medical therapy (GDMT), device therapy, and eventual reverse remodeling. Evidence of structural heart improvement continued far beyond 1 year.http://dx.doi.org/10.1155/2024/5278240 |
| spellingShingle | Lekha Racharla Lucas Gitzel Max Joseph Desire Guthier Nael Hawwa Ivabradine and Milrinone—Bridge to Recovery in New HFrEF With Low-Output Heart Failure Case Reports in Cardiology |
| title | Ivabradine and Milrinone—Bridge to Recovery in New HFrEF With Low-Output Heart Failure |
| title_full | Ivabradine and Milrinone—Bridge to Recovery in New HFrEF With Low-Output Heart Failure |
| title_fullStr | Ivabradine and Milrinone—Bridge to Recovery in New HFrEF With Low-Output Heart Failure |
| title_full_unstemmed | Ivabradine and Milrinone—Bridge to Recovery in New HFrEF With Low-Output Heart Failure |
| title_short | Ivabradine and Milrinone—Bridge to Recovery in New HFrEF With Low-Output Heart Failure |
| title_sort | ivabradine and milrinone bridge to recovery in new hfref with low output heart failure |
| url | http://dx.doi.org/10.1155/2024/5278240 |
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