Aberrant FGF signaling promotes granule neuron precursor expansion in SHH subgroup infantile medulloblastoma

Aberrant FGF signaling promotes granule neuron precursor expansion in SHH subgroup infantile medulloblastoma

Mutations in Sonic Hedgehog (SHH) signaling pathway genes, for example, Suppressor of Fused (SUFU), drive granule neuron precursors (GNP) to form medulloblastomas (MBSHH). However, how different molecular lesions in the Shh pathway drive transformation is frequently unclear, and SUFU mutations in th...

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Bibliographic Details
Main Authors: Odessa R Yabut, Jessica Arela, Hector G Gomez, Jesse Garcia Castillo, Thomas Ngo, Samuel J Pleasure
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-01-01
Series:eLife
Subjects:
Sonic Hedgehog
Sufu
medulloblastoma
p53
Online Access:https://elifesciences.org/articles/100767
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