Differential Impact of Stress Reduction Programs upon Ambulatory Blood Pressure among African American Adolescents: Influences of Endothelin-1 Gene and Chronic Stress Exposure
Stress-activated gene × environment interactions may contribute to individual variability in blood pressure reductions from behavioral interventions. We investigated effects of endothelin-1 (ET-1) LYS198ASN SNP and discriminatory stress exposure upon impact of 12-week behavioral interventions upon a...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2012/510291 |
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| author | Mathew J. Gregoski Vernon A. Barnes Martha S. Tingen Yanbin Dong Haidong Zhu Frank A. Treiber |
| author_facet | Mathew J. Gregoski Vernon A. Barnes Martha S. Tingen Yanbin Dong Haidong Zhu Frank A. Treiber |
| author_sort | Mathew J. Gregoski |
| collection | DOAJ |
| description | Stress-activated gene × environment interactions may contribute to individual variability in blood pressure reductions from behavioral interventions. We investigated effects of endothelin-1 (ET-1) LYS198ASN SNP and discriminatory stress exposure upon impact of 12-week behavioral interventions upon ambulatory BP (ABP) among 162 prehypertensive African American adolescents. Following genotyping, completion of questionnaire battery, and 24-hour ABP monitoring, participants were randomized to health education control (HEC), life skills training (LST), or breathing awareness meditation (BAM). Postintervention ABP was obtained. Significant three-way interactions on ABP changes indicated that among ET-1 SNP carriers, the only group to show reductions was BAM from low chronic stress environments. Among ET-1 SNP noncarriers, under low chronic stress exposure, all approaches worked, especially BAM. Among high stress exposure noncarriers, only BAM resulted in reductions. If these preliminary findings are replicated via ancillary analyses of archival databases and then via efficacy trials, selection of behavioral prescriptions for prehypertensives will be edging closer to being guided by individual's underlying genetic and environmental factors incorporating the healthcare model of personalized preventive medicine. |
| format | Article |
| id | doaj-art-a9bc803a91a140989b9c0868bf0182f1 |
| institution | Kabale University |
| issn | 2090-0384 2090-0392 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-a9bc803a91a140989b9c0868bf0182f12025-02-03T01:02:36ZengWileyInternational Journal of Hypertension2090-03842090-03922012-01-01201210.1155/2012/510291510291Differential Impact of Stress Reduction Programs upon Ambulatory Blood Pressure among African American Adolescents: Influences of Endothelin-1 Gene and Chronic Stress ExposureMathew J. Gregoski0Vernon A. Barnes1Martha S. Tingen2Yanbin Dong3Haidong Zhu4Frank A. Treiber5Colleges of Nursing and Medicine, Medical University of South Carolina, Charleston, SC 29425, USAGeorgia Institute for Prevention of Human Diseases and Accidents, Department of Pediatrics, Georgia Health Sciences University, Augusta, GA 30912, USAGeorgia Institute for Prevention of Human Diseases and Accidents, Department of Pediatrics, Georgia Health Sciences University, Augusta, GA 30912, USAGeorgia Institute for Prevention of Human Diseases and Accidents, Department of Pediatrics, Georgia Health Sciences University, Augusta, GA 30912, USAGeorgia Institute for Prevention of Human Diseases and Accidents, Department of Pediatrics, Georgia Health Sciences University, Augusta, GA 30912, USAColleges of Nursing and Medicine, Medical University of South Carolina, Charleston, SC 29425, USAStress-activated gene × environment interactions may contribute to individual variability in blood pressure reductions from behavioral interventions. We investigated effects of endothelin-1 (ET-1) LYS198ASN SNP and discriminatory stress exposure upon impact of 12-week behavioral interventions upon ambulatory BP (ABP) among 162 prehypertensive African American adolescents. Following genotyping, completion of questionnaire battery, and 24-hour ABP monitoring, participants were randomized to health education control (HEC), life skills training (LST), or breathing awareness meditation (BAM). Postintervention ABP was obtained. Significant three-way interactions on ABP changes indicated that among ET-1 SNP carriers, the only group to show reductions was BAM from low chronic stress environments. Among ET-1 SNP noncarriers, under low chronic stress exposure, all approaches worked, especially BAM. Among high stress exposure noncarriers, only BAM resulted in reductions. If these preliminary findings are replicated via ancillary analyses of archival databases and then via efficacy trials, selection of behavioral prescriptions for prehypertensives will be edging closer to being guided by individual's underlying genetic and environmental factors incorporating the healthcare model of personalized preventive medicine.http://dx.doi.org/10.1155/2012/510291 |
| spellingShingle | Mathew J. Gregoski Vernon A. Barnes Martha S. Tingen Yanbin Dong Haidong Zhu Frank A. Treiber Differential Impact of Stress Reduction Programs upon Ambulatory Blood Pressure among African American Adolescents: Influences of Endothelin-1 Gene and Chronic Stress Exposure International Journal of Hypertension |
| title | Differential Impact of Stress Reduction Programs upon Ambulatory Blood Pressure among African American Adolescents: Influences of Endothelin-1 Gene and Chronic Stress Exposure |
| title_full | Differential Impact of Stress Reduction Programs upon Ambulatory Blood Pressure among African American Adolescents: Influences of Endothelin-1 Gene and Chronic Stress Exposure |
| title_fullStr | Differential Impact of Stress Reduction Programs upon Ambulatory Blood Pressure among African American Adolescents: Influences of Endothelin-1 Gene and Chronic Stress Exposure |
| title_full_unstemmed | Differential Impact of Stress Reduction Programs upon Ambulatory Blood Pressure among African American Adolescents: Influences of Endothelin-1 Gene and Chronic Stress Exposure |
| title_short | Differential Impact of Stress Reduction Programs upon Ambulatory Blood Pressure among African American Adolescents: Influences of Endothelin-1 Gene and Chronic Stress Exposure |
| title_sort | differential impact of stress reduction programs upon ambulatory blood pressure among african american adolescents influences of endothelin 1 gene and chronic stress exposure |
| url | http://dx.doi.org/10.1155/2012/510291 |
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