Neuregulin 1 improves cognitive deficits and neuropathology in an Alzheimer’s disease model

Neuregulin 1 improves cognitive deficits and neuropathology in an Alzheimer’s disease model

Abstract Several lines of evidence suggest that neuregulin 1 (NRG1) signaling may influence cognitive function and neuropathology in Alzheimer’s disease (AD). To test this possibility, full-length type I or type III NRG1 was overexpressed via lentiviral vectors in the hippocampus of line 41 AD mouse...

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Bibliographic Details
Main Authors: Jiqing Xu, Fred de Winter, Catherine Farrokhi, Edward Rockenstein, Michael Mante, Anthony Adame, Jonathan Cook, Xin Jin, Eliezer Masliah, Kuo-Fen Lee
Format: Article
Language:English
Published: Nature Portfolio 2016-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/srep31692
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