Marine natural products as a source of novel anticancer drugs: an updated review (2019–2023)
Abstract Marine natural products have long been recognized as a vast and diverse source of bioactive compounds with potential therapeutic applications, particularly in oncology. This review provides an updated overview of the significant advances made in the discovery and development of marine-deriv...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-01-01
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| Series: | Natural Products and Bioprospecting |
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| Online Access: | https://doi.org/10.1007/s13659-024-00493-5 |
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| author | Hesham R. El-Seedi Mohamed S. Refaey Nizar Elias Mohamed F. El-Mallah Faisal M. K. Albaqami Ismail Dergaa Ming Du Mohamed F. Salem Haroon Elrasheid Tahir Maria Dagliaa Nermeen Yosri Hongcheng Zhang Awg H. El-Seedi Zhiming Guo Shaden A. M. Khalifa |
| author_facet | Hesham R. El-Seedi Mohamed S. Refaey Nizar Elias Mohamed F. El-Mallah Faisal M. K. Albaqami Ismail Dergaa Ming Du Mohamed F. Salem Haroon Elrasheid Tahir Maria Dagliaa Nermeen Yosri Hongcheng Zhang Awg H. El-Seedi Zhiming Guo Shaden A. M. Khalifa |
| author_sort | Hesham R. El-Seedi |
| collection | DOAJ |
| description | Abstract Marine natural products have long been recognized as a vast and diverse source of bioactive compounds with potential therapeutic applications, particularly in oncology. This review provides an updated overview of the significant advances made in the discovery and development of marine-derived anticancer drugs between 2019 and 2023. With a focus on recent research findings, the review explores the rich biodiversity of marine organisms, including sponges, corals, algae, and microorganisms, which have yielded numerous compounds exhibiting promising anticancer properties. Emphasizing the multifaceted mechanisms of action, the review discusses the molecular targets and pathways targeted by these compounds, such as cell cycle regulation, apoptosis induction, angiogenesis inhibition, and modulation of signaling pathways. Additionally, the review highlights the innovative strategies employed in the isolation, structural elucidation, and chemical modification of marine natural products to enhance their potency, selectivity, and pharmacological properties. Furthermore, it addresses the challenges and opportunities associated with the development of marine-derived anticancer drugs, including issues related to supply, sustainability, synthesis, and clinical translation. Finally, the review underscores the immense potential of marine natural products as a valuable reservoir of novel anticancer agents and advocates for continued exploration and exploitation of the marine environment to address the unmet medical needs in cancer therapy Graphical Abstract |
| format | Article |
| id | doaj-art-a98423f88c2f4cbcbc4b9f4930c33e75 |
| institution | Kabale University |
| issn | 2192-2195 2192-2209 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Natural Products and Bioprospecting |
| spelling | doaj-art-a98423f88c2f4cbcbc4b9f4930c33e752025-01-26T12:57:50ZengSpringerOpenNatural Products and Bioprospecting2192-21952192-22092025-01-0115114310.1007/s13659-024-00493-5Marine natural products as a source of novel anticancer drugs: an updated review (2019–2023)Hesham R. El-Seedi0Mohamed S. Refaey1Nizar Elias2Mohamed F. El-Mallah3Faisal M. K. Albaqami4Ismail Dergaa5Ming Du6Mohamed F. Salem7Haroon Elrasheid Tahir8Maria Dagliaa9Nermeen Yosri10Hongcheng Zhang11Awg H. El-Seedi12Zhiming Guo13Shaden A. M. Khalifa14Department of Chemistry, Faculty of Science, Islamic University of MadinahDepartment of Pharmacognosy, Faculty of Pharmacy, University of Sadat CityDepartment of Laboratory Medicine, Faculty of Medicine, University of KalamoonDepartment of Chemistry, Faculty of Science, Menoufia UniversityBiology Department, Faculty of Science, Islamic University of MadinahPrimary Health Care Corporation (PHCC)School of Food Science and Technology, National Engineering Research Center of Seafood, Dalian Polytechnic UniversityDepartment of Environmental Biotechnology, Genetic Engineering and Biotechnology Research Institute, GEBRI, University of Sadat CityAgricultural Product Processing and Storage Lab, School of Food and Biological Engineering, Jiangsu UniversityInternational Research Center for Food Nutrition and Safety, Jiangsu UniversitySchool of Food and Biological Engineering, Jiangsu UniversityState Key Laboratory of Resource Insects, Institute of Apicultural Research, Chinese Academy of Agricultural SciencesInternational IT College of Sweden Stockholm, Arena AcademySchool of Food and Biological Engineering, Jiangsu UniversityInternational Research Center for Food Nutrition and Safety, Jiangsu UniversityAbstract Marine natural products have long been recognized as a vast and diverse source of bioactive compounds with potential therapeutic applications, particularly in oncology. This review provides an updated overview of the significant advances made in the discovery and development of marine-derived anticancer drugs between 2019 and 2023. With a focus on recent research findings, the review explores the rich biodiversity of marine organisms, including sponges, corals, algae, and microorganisms, which have yielded numerous compounds exhibiting promising anticancer properties. Emphasizing the multifaceted mechanisms of action, the review discusses the molecular targets and pathways targeted by these compounds, such as cell cycle regulation, apoptosis induction, angiogenesis inhibition, and modulation of signaling pathways. Additionally, the review highlights the innovative strategies employed in the isolation, structural elucidation, and chemical modification of marine natural products to enhance their potency, selectivity, and pharmacological properties. Furthermore, it addresses the challenges and opportunities associated with the development of marine-derived anticancer drugs, including issues related to supply, sustainability, synthesis, and clinical translation. Finally, the review underscores the immense potential of marine natural products as a valuable reservoir of novel anticancer agents and advocates for continued exploration and exploitation of the marine environment to address the unmet medical needs in cancer therapy Graphical Abstracthttps://doi.org/10.1007/s13659-024-00493-5Marine natural productsMicroorganismAnticancerClinical trialsDrugs |
| spellingShingle | Hesham R. El-Seedi Mohamed S. Refaey Nizar Elias Mohamed F. El-Mallah Faisal M. K. Albaqami Ismail Dergaa Ming Du Mohamed F. Salem Haroon Elrasheid Tahir Maria Dagliaa Nermeen Yosri Hongcheng Zhang Awg H. El-Seedi Zhiming Guo Shaden A. M. Khalifa Marine natural products as a source of novel anticancer drugs: an updated review (2019–2023) Natural Products and Bioprospecting Marine natural products Microorganism Anticancer Clinical trials Drugs |
| title | Marine natural products as a source of novel anticancer drugs: an updated review (2019–2023) |
| title_full | Marine natural products as a source of novel anticancer drugs: an updated review (2019–2023) |
| title_fullStr | Marine natural products as a source of novel anticancer drugs: an updated review (2019–2023) |
| title_full_unstemmed | Marine natural products as a source of novel anticancer drugs: an updated review (2019–2023) |
| title_short | Marine natural products as a source of novel anticancer drugs: an updated review (2019–2023) |
| title_sort | marine natural products as a source of novel anticancer drugs an updated review 2019 2023 |
| topic | Marine natural products Microorganism Anticancer Clinical trials Drugs |
| url | https://doi.org/10.1007/s13659-024-00493-5 |
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