Exhaled Breath Condensate: A Promising Source for Biomarkers of Lung Disease
Exhaled breath condensate (EBC) has been increasingly studied as a noninvasive research method for sampling the alveolar and airway space and is recognized as a promising source of biomarkers of lung diseases. Substances measured in EBC include oxidative stress and inflammatory mediators, such as ar...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/217518 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832564984031215616 |
|---|---|
| author | Yan Liang Samantha M. Yeligar Lou Ann S. Brown |
| author_facet | Yan Liang Samantha M. Yeligar Lou Ann S. Brown |
| author_sort | Yan Liang |
| collection | DOAJ |
| description | Exhaled breath condensate (EBC) has been increasingly studied as a noninvasive research method for sampling the alveolar and airway space and is recognized as a promising source of biomarkers of lung diseases. Substances measured in EBC include oxidative stress and inflammatory mediators, such as arachidonic acid derivatives, reactive oxygen/nitrogen species, reduced and oxidized glutathione, and inflammatory cytokines. Although EBC has great potential as a source of biomarkers in many lung diseases, the low concentrations of compounds within the EBC present challenges in sample collection and analysis. Although EBC is viewed as a noninvasive method for sampling airway lining fluid (ALF), validation is necessary to confirm that EBC truly represents the ALF. Likewise, a dilution factor for the EBC is needed in order to compare across subjects and determine changes in the ALF. The aims of this paper are to address the characteristics of EBC; strategies to standardize EBC sample collection and review available analytical techniques for EBC analysis. |
| format | Article |
| id | doaj-art-a97f8dad6b1e49709b34372eb399a454 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-a97f8dad6b1e49709b34372eb399a4542025-02-03T01:09:41ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/217518217518Exhaled Breath Condensate: A Promising Source for Biomarkers of Lung DiseaseYan Liang0Samantha M. Yeligar1Lou Ann S. Brown2Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Emory University and Emory+Children's Healthcare of Atlanta Center for Developmental Lung Biology, Atlanta, GA 30322, USADivision of Neonatal-Perinatal Medicine, Department of Pediatrics, Emory University and Emory+Children's Healthcare of Atlanta Center for Developmental Lung Biology, Atlanta, GA 30322, USADivision of Neonatal-Perinatal Medicine, Department of Pediatrics, Emory University and Emory+Children's Healthcare of Atlanta Center for Developmental Lung Biology, Atlanta, GA 30322, USAExhaled breath condensate (EBC) has been increasingly studied as a noninvasive research method for sampling the alveolar and airway space and is recognized as a promising source of biomarkers of lung diseases. Substances measured in EBC include oxidative stress and inflammatory mediators, such as arachidonic acid derivatives, reactive oxygen/nitrogen species, reduced and oxidized glutathione, and inflammatory cytokines. Although EBC has great potential as a source of biomarkers in many lung diseases, the low concentrations of compounds within the EBC present challenges in sample collection and analysis. Although EBC is viewed as a noninvasive method for sampling airway lining fluid (ALF), validation is necessary to confirm that EBC truly represents the ALF. Likewise, a dilution factor for the EBC is needed in order to compare across subjects and determine changes in the ALF. The aims of this paper are to address the characteristics of EBC; strategies to standardize EBC sample collection and review available analytical techniques for EBC analysis.http://dx.doi.org/10.1100/2012/217518 |
| spellingShingle | Yan Liang Samantha M. Yeligar Lou Ann S. Brown Exhaled Breath Condensate: A Promising Source for Biomarkers of Lung Disease The Scientific World Journal |
| title | Exhaled Breath Condensate: A Promising Source for Biomarkers of Lung Disease |
| title_full | Exhaled Breath Condensate: A Promising Source for Biomarkers of Lung Disease |
| title_fullStr | Exhaled Breath Condensate: A Promising Source for Biomarkers of Lung Disease |
| title_full_unstemmed | Exhaled Breath Condensate: A Promising Source for Biomarkers of Lung Disease |
| title_short | Exhaled Breath Condensate: A Promising Source for Biomarkers of Lung Disease |
| title_sort | exhaled breath condensate a promising source for biomarkers of lung disease |
| url | http://dx.doi.org/10.1100/2012/217518 |
| work_keys_str_mv | AT yanliang exhaledbreathcondensateapromisingsourceforbiomarkersoflungdisease AT samanthamyeligar exhaledbreathcondensateapromisingsourceforbiomarkersoflungdisease AT louannsbrown exhaledbreathcondensateapromisingsourceforbiomarkersoflungdisease |