Efficacy of Venetoclax and Dexamethasone in Refractory IgM Primary Plasma Cell Leukemia with t(11;14) and TP53 Mutation: A Case Report and Literature Review
Primary plasma cell leukemia (pPCL) is an uncommon disease. IgM multiple myeloma (MM) is an infrequent subtype that accounts for less than 1 percent of MM cases. IgM pPCL is quite rare with only a few cases published to date. We describe a case of a patient with IgM pPCL who initially presented with...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2020/8823877 |
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| author | Salimah Valliani Mir Ali Omar Mahmoo Sanjay Hinduja Calvin K. Chen Lloyd Damon Haifaa Abdulhaq |
| author_facet | Salimah Valliani Mir Ali Omar Mahmoo Sanjay Hinduja Calvin K. Chen Lloyd Damon Haifaa Abdulhaq |
| author_sort | Salimah Valliani |
| collection | DOAJ |
| description | Primary plasma cell leukemia (pPCL) is an uncommon disease. IgM multiple myeloma (MM) is an infrequent subtype that accounts for less than 1 percent of MM cases. IgM pPCL is quite rare with only a few cases published to date. We describe a case of a patient with IgM pPCL who initially presented with hyperviscosity syndrome requiring urgent plasma exchange. His bone marrow biopsy demonstrated t(11;14). He progressed on proteasome inhibitors, immunomodulating agents, and other chemotherapy medications but later achieved very good partial response (VGPR) to venetoclax and dexamethasone. Given the poor prognosis of pPCL, further studies using venetoclax alone or in combination with other novel agents as first-line treatment options are warranted particularly in patients with t(11;14). |
| format | Article |
| id | doaj-art-a97b41894ec24625a3e16f8ea093cb78 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-a97b41894ec24625a3e16f8ea093cb782025-02-03T01:28:08ZengWileyCase Reports in Hematology2090-65602090-65792020-01-01202010.1155/2020/88238778823877Efficacy of Venetoclax and Dexamethasone in Refractory IgM Primary Plasma Cell Leukemia with t(11;14) and TP53 Mutation: A Case Report and Literature ReviewSalimah Valliani0Mir Ali1Omar Mahmoo2Sanjay Hinduja3Calvin K. Chen4Lloyd Damon5Haifaa Abdulhaq6University of California San Francisco-Fresno (UCSF Fresno), Fresno, California, USAUniversity of California San Francisco-Fresno (UCSF Fresno), Fresno, California, USAUniversity of California San Francisco-Fresno (UCSF Fresno), Fresno, California, USAUniversity of California San Francisco-Fresno (UCSF Fresno), Fresno, California, USACommunity Regional Medical Center (CRMC), Fresno, California, USAUniversity of California San Francisco (UCSF), San Francisco, California, USAUniversity of California San Francisco-Fresno (UCSF Fresno), Fresno, California, USAPrimary plasma cell leukemia (pPCL) is an uncommon disease. IgM multiple myeloma (MM) is an infrequent subtype that accounts for less than 1 percent of MM cases. IgM pPCL is quite rare with only a few cases published to date. We describe a case of a patient with IgM pPCL who initially presented with hyperviscosity syndrome requiring urgent plasma exchange. His bone marrow biopsy demonstrated t(11;14). He progressed on proteasome inhibitors, immunomodulating agents, and other chemotherapy medications but later achieved very good partial response (VGPR) to venetoclax and dexamethasone. Given the poor prognosis of pPCL, further studies using venetoclax alone or in combination with other novel agents as first-line treatment options are warranted particularly in patients with t(11;14).http://dx.doi.org/10.1155/2020/8823877 |
| spellingShingle | Salimah Valliani Mir Ali Omar Mahmoo Sanjay Hinduja Calvin K. Chen Lloyd Damon Haifaa Abdulhaq Efficacy of Venetoclax and Dexamethasone in Refractory IgM Primary Plasma Cell Leukemia with t(11;14) and TP53 Mutation: A Case Report and Literature Review Case Reports in Hematology |
| title | Efficacy of Venetoclax and Dexamethasone in Refractory IgM Primary Plasma Cell Leukemia with t(11;14) and TP53 Mutation: A Case Report and Literature Review |
| title_full | Efficacy of Venetoclax and Dexamethasone in Refractory IgM Primary Plasma Cell Leukemia with t(11;14) and TP53 Mutation: A Case Report and Literature Review |
| title_fullStr | Efficacy of Venetoclax and Dexamethasone in Refractory IgM Primary Plasma Cell Leukemia with t(11;14) and TP53 Mutation: A Case Report and Literature Review |
| title_full_unstemmed | Efficacy of Venetoclax and Dexamethasone in Refractory IgM Primary Plasma Cell Leukemia with t(11;14) and TP53 Mutation: A Case Report and Literature Review |
| title_short | Efficacy of Venetoclax and Dexamethasone in Refractory IgM Primary Plasma Cell Leukemia with t(11;14) and TP53 Mutation: A Case Report and Literature Review |
| title_sort | efficacy of venetoclax and dexamethasone in refractory igm primary plasma cell leukemia with t 11 14 and tp53 mutation a case report and literature review |
| url | http://dx.doi.org/10.1155/2020/8823877 |
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